Triterpenes fromMaytenus ilicifolia

Itokawa, Hideji; Shirota, Osamu; Ikuta, Hiroshi; Morita, Hiroshi; Takeya, Koichi; Iitaka, Yōichi

doi:10.1016/0031-9422(91)80096-j

Cited by 109 publications

(108 citation statements)

References 14 publications

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“…Its purity, which was estimated to be higher than 95%, was determined by TLC analysis using different solvent systems and by 13 C NMR. Analysis of both 1 H and 13 C NMR spectra, in comparison with the data published by Itokawa et al (1991), allowed to propose the structure of populnoic acid for the isolated compound.…”

Section: Populnoic Acid Isolationmentioning

confidence: 91%

Antiulcerogenic Activity of Crude Extract, Fractions and Populnoic Acid Isolated from Austroplenckia populnea (Celastraceae)

Andrade

Antoniolli

Comunello

et al. 2006

Zeitschrift Für Naturforschung C

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Many plant crude extracts and their isolated compounds are the most attractive sources of new drugs and show promising results for the treatment of gastric ulcers. Austroplenckia populnea is commonly known as "marmelinho-do campo, mangabeira-brava, mangabarana and vime" and it has been used in folk medicine as anti-dysenteric and anti-rheumatic. Powdered bark wood (3.25 kg) was macerated with aqueous ethanol (96%) and the extract was concentrated under reduced pressure to yield 406 g of crude hydralcoholic extract. The hydralcoholic extract was suspended in aqueous methanol and partitioned with hexane, chloroform and ethyl acetate (EtOAc) in sequence, yielding 8.0 g, 9.5 g and 98.17 g of crude extracts, respectively. Chromatography of the hexane extract over a silica gel column led to the isolation of the triterpene populnoic acid. The oral administration of hydralcoholic, hexane, chloroform and EtOAc extracts (200 mg/kg) decreased the ulcer lesion index (ULI) by 83.15%, 46.87%, 32.2%, 68.12%, respectively. Oral administration of populnoic acid (100 mg/ kg) diminished the ULI by 55.29%. All the obtained results were significant in comparison with the negative control, with exception of the chloroform extract.

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Section: Populnoic Acid Isolationmentioning

confidence: 91%

Antiulcerogenic Activity of Crude Extract, Fractions and Populnoic Acid Isolated from Austroplenckia populnea (Celastraceae)

Andrade

Antoniolli

Comunello

et al. 2006

Zeitschrift Für Naturforschung C

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“…Celastrol (65) was toxic to several human cancer cell lines (Kutney et al, 1981a;Figueiredo et al, 1998;González et al, 1998;Ankli et al, 2000;Zhou et al, 2002;Lee et al, 2004) and inhibited TPA-induced EBV-EA . Pristimerin (64) and tingenone (66) were also toxic to numerous cancer cell lines (Gonzalez et al, 1977;Kutney et al, 1981a,b;Itokawa et al, 1991;Ngassapa et al, 1994;Shirota et al, 1994;Figueiredo et al, 1998;González et al, 1998;Setzer et al, 1998Setzer et al, , 2001Lee et al, 2004). 22β-Hydroxy-tingenone (67) was about as cytotoxic as 64 and 66 (Kutney et al, 1981b;Bavovada et al, 1990;Itokawa et al, 1991;Shirota et al, 1994;Sattar et al, 1998;, which were generally more toxic than 65 (Ngassapa et al, 1994;Ankli et al, 2000;Chang et al, 2003).…”

Section: Cancermentioning

confidence: 99%

“…Polpunonic acid (69) and 3-oxofriedelan-28-oic acid (70) were weakly to moderately cytotoxic to cancer cell lines; 3β,29-dihydroxy-D:B-friedoolean-5-en (71) and 29-hydroxy-friedelan-3-one (=D:A-friedooleanan-29-ol-3-one) (74) were less active (Nozaki et al, 1990;Itokawa et al, 1991;Chiang et al, 2005). Salaspermic acid (76) weakly stimulated proapoptotic cytokines, suggesting the possibility of antitumor activity (Nakagawa et al, 2004).…”

Section: Cancermentioning

confidence: 99%

Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae)

et al. 2007

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Plants in the genus Tripterygium, such as Tripterygium wilfordii Hook. f., have a long history of use in traditional Chinese medicine. In recent years there has been considerable interest in the use of Tripterygium extracts and of the main bioactive constituent, the diterpene triepoxide triptolide (1), to treat a variety of autoimmune and inflammation-related conditions. The main mode of action of the Tripterygium extracts and triptolide (1) is the inhibition of expression of proinflammatory genes such as those for interleukin-2 (IL-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor-α (TNF-α), cyclooxygenase-2 (COX-2) and interferon-gamma (IFN-γ). The efficacy and safety of certain types of Tripterygium extracts were confirmed in human clinical trials in the US and abroad. Over 300 compounds have been identified in the genus Tripterygium, and many of these have been evaluated for biological activity. The overall activity of the extract is based on the interaction between its components. Therefore, the safety and efficacy of the extract cannot be fully mimicked by any individual constituent. This review discusses the biochemical composition and biological and pharmacological activities of Tripterygium extracts, and their main bioactive components.

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“…4,5) For a decade, we have studied chemical constituents of this species, because they are rich sources of terpenoids such as dihydro-b-agarofuran sesquiterpenes, 6,7) sesquiterpene pyridine alkaloids, [8][9][10] highly oxidized friedelane triterpenes, 11) and triterpene dimers. [12][13][14][15][16] Among them, the triterpene dimer comprise quite a unique class of compounds, which are composed of two quinone methide derived triterpenes joined by two ether linkages between the A rings, represented by xuxuarines, 12,[14][15][16] or between the A and B rings, represented by cangorosin A.…”

mentioning

confidence: 99%