Triterpenes from Salvia argentea var. aurasiaca and their antibacterial and cytotoxic activities

Abstract

Five undescribed ursane-type triterpenes, identified as 1β,3β,15α-trihydroxy-urs-9(11)-12-diene (1), 1β,3β,15α,28-tetrahydroxy-urs-9(11),12-diene (2), 1β,3β-dihydroxy-urs-9(11),12-dien-28-al (3), 1β,3β,7β,15α,28-pentahydroxy-urs-12-ene (4), and 1β,3β,15α-trihydroxy-urs-11-en-28-al (5), together with five known compounds (6-10), were isolated from the acetone extract of the dried aerial parts of Salvia argentea L. var. aurasiaca (Pomel) Batt. et Trab. (Lamiaceae). Structures were elucidated on the basis of extensive spectroscopic analysis including HR-ESI-MS, 1D-and 2D-NMR techniques and comparison with literature data. The antibacterial evaluation of compounds 1-10 of the acetone extract of the dried aerial parts, in addition to nine compounds (11-19) previously isolated from the exudate of the fresh aerial parts, by bioautography on Staphylococcus aureus followed by the determination of MIC values of active compounds by serial dilution technique against five bacteria, revealed that two compounds have an antibacterial effect comparable to antibiotics. The cytotoxic activity evaluation of compounds 1-19 showed that Six compounds exhibited an antiproliferative activity against K562 and HT1080 cells with IC50 values ranging from 30.25 to 70.32 µM.

Pharmacological and Nutritional Properties: Genus Salvia

“…It has been reported that S. longipedicellata is effective against S. aureus, B. subtilis, E. coli, C. albicans, C. tropicalis and C. glabrata [107]. It has been reported that S. argentea is effective against S. aureus [108]. S. xanthocheila, S. atropatana, S. limbata, and S. nemorosa have been reported to be effective against E. coli, K. pneumoniae, S. typhi, S. aureus, S. epidermidis, B. subtilis [55].…”

“…It has been reported that S. aethiopis has cytotoxic activity [105]. S. argentea has been reported to show cytotoxic activity against myelogenous leukemia (K562) and fibrosarcoma (HT1080) cell lines [108]. It has been reported that S. xanthocheila, S. atropatana, S. limbata and S. nemorosa are effective against 3 cancer cell lines using the MTT test [109].…”