Triterpenes and Lignans from Artemisia caruifolia and Their Cytotoxic Effects on Meth-A and LLC Tumor Cell Lines.

Cytotoxic Sesquiterpenes from Magnolia kachirachirai

“…), CHO showed correlations with HÀC(3), confirming an (E)-C¼C bond. According to the above data, the structure of 15 was elucidated as (E)-2,3-bis(4-hydroxy-3-methoxyphenyl)prop-2-enal, which was further confirmed by additional COSY, 13 C-NMR ( (2) and HÀC(2')), 7.30 (dd, J ¼ 8.4, 1.6, HÀC(6) and HÀC(6')), and . From the NOESY spectrum (Fig.…”

“…This finding was also supported by the fact that HÀC (5) showed no correlations with HÀC (9) and HÀC (14). Based on the 1 H-and 13 C-NMR (Table 1), COSY, HSQC, NOESY (Fig. ), and HMBC ( Table 1) experiments, the structure of 1 was elucidated, and the compound was named kachiraterpenol.…”

“…The g-lactone moiety of the 3,7-dioxabicyclo[3.3.0]octan-2-one group was also confirmed by an IR absorption at 1761 cm À 1 (C¼O). The structure of 19 is similar to caruilignan D [13], except that the 4-hydroxy-3,5-dimethoxyphenyl group of caruilignan D is replaced by the 3-hydroxy-4,5-dimethoxyphenyl group of 19, and showed a configuration differing from that of caruilignan D at C(6). In the NOESY spectrum ( (19), which was confirmed by COSY, DEPT, HMQC, and HMBC (Table 3) experiments.…”

“…In the 1 H-NMR spectrum, the chemical shifts of HÀC(6) (0.2 ppm) and HÀC(11) (0.3 ppm) of 11b,13-dihydrosesquiterpene lactones were at higher field than those of 11a,13-dihydrosesquiterpene lactones. In the 13 C-NMR spectrum, the chemical shift of C(13) of 11b,13-dihydrosesquiterpene lactones was always a lower field absorption at d(C) 12.0. On the other hand, 11a,13-dihydrosesquiterpene lactones always show a higher field for C (13) at d(C) 10.0.…”

“…In the 13 C-NMR spectrum, the chemical shift of C(13) of 11b,13-dihydrosesquiterpene lactones was always a lower field absorption at d(C) 12.0. On the other hand, 11a,13-dihydrosesquiterpene lactones always show a higher field for C (13) at d(C) 10.0. These observations provide a useful method to identify the eudesmanolide-type sesquiterpenoid, which shows a different configuration at C(11) according to 1 H-or 13 C-NMR spectrum.…”