Triterpenes and B-sitosterol from piper betle: isolation, antiplatelet and anti-inflammatory effects

Saeed, Sheikh A.; Farnaz, Samina; Simjee, Rukhsana U.; Malik, Abdul

doi:10.1042/bst021462s

Cited by 43 publications

(35 citation statements)

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“…Traditionally, the roots has been used for the treatment of wind-cold cough, bronchial asthma, rheumatism, stomachalgia, edema of pregnancy, and as a contraceptive [4,5]. In previous phytochemical studies, several compounds, including β-sitosteryl palmitate, 3β-acetate ursolic acid, ursolic acid, 4-allylresorcinol, stigmast-4-en-3,6-dione and aristololactam A-II, have been isolated from the roots of P. betle [6][7][8]. Recently, we found that the ethanolic extract of the roots of this plant exhibited anti-inflammatory effects.…”

Section: Introductionmentioning

confidence: 99%

A New Hydroxychavicol Dimer from the Roots of Piper betle

et al. 2013

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Abstract:A new hydroxychavicol dimer, 2-('-hydroxychavicol)-hydroxychavicol (1), was isolated from the roots of Piper betle Linn. along with five known compounds, hydroxychavicol (2), aristololactam A II (3), aristololactam B II (4), piperolactam A (5) and cepharadione A (6). The structures of these isolated compounds were elucidated by spectroscopic methods. Compounds 1 and 2 exhibited inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.

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Section: Introductionmentioning

confidence: 99%

A New Hydroxychavicol Dimer from the Roots of Piper betle

et al. 2013

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“…Flandren has anti-inflammatory and analgesic properties 19 . It is also used in the perfumery industry due to its pleasing fragrance 28 .…”

Section: Discussionmentioning

confidence: 99%

“…Multiple reports in various articles show large pharmaceutical activity of Peganum harmala, including inhibiting the growth of MAO (Monoamine Oxidase) and anti-bacterial and antifungal activity 1 . In addition, it was found that this plant is capable of aborting and is effective in the treatment of dermatitis 19 , reducing the temperature 1 and cancer 1 .…”

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confidence: 99%

Peganum harmala and Piper longum Plant Rubbing Oil Effect on Pain in Small Male Mice

Moradi¹,

Yousofvand²

2016

Biosci., Biotech. Res. Asia

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Peganum harmala and Piper longum medicinal herbs are used in traditional medicine to treat various diseases and to relieve tragic processes. The chemical composition of these two compounds is their analgesic agent. The purpose of this study was the Peganum harmala and Piper longum rubbing oil effect on pain in male mice by using formalin test. In this study, male mice were divided into three groups: control group, Peganum harmala rubbing oil group, Piper longum rubbing oil group. All groups were taken formalin test and data were analyzed by using Graphpad prism statistical software. In rubbing groups, Peganum harmala rubbing oil and the Piper longum rubbing oil, there was a significant difference compared with the control group (p<0.05). It seems that the reason of these two plants analgesic should be sought in their chemical composition. The chemical compositions of these two plants have analgesic effects.

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“…However, it has been reported that P. harmala contains some flavonoids (Sharaf, 1997). P. harmala alkaloids have a wide spectrum of pharmacological action let including plate aggregation inhibition (Saeed, 1993), mono amine oxidase inhibition, anxiolyticand behavioral effects, and immune modulator influences (Wang, 1996). There were some reports concerning the cardio vascular actions of harmala alkaloids such as harmine, harmaline and harmalol that reduced systemic arterial blood pressure and total peripheral vascular resistance (Wang, 1997).…”

Section: Introductionmentioning

confidence: 99%

Effect of Peganum harmala L. on lipid metabolism and changes HMGcoA reductase in Hypercholesterolemia-induced male wistar Rat

Far¹,

Fazaely²,

Sharifia³

et al. 2015

The European Proceedings of Social and Behavioural Sciences

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Background: Concentration of cholesterol and other lipids in human diet has been considered as an issue of public health. In the present study the Effects of Peganum harmala (P. harmala) on lipid metabolism were investigated in a 28-days feeding trial. Methods: Total of 64 rats (200±15) were divided into six groups: (G1) control, G2) control plus 100mg/kg, G3) control plus 200mg/kg, G4) control plus 400mg/kg. , G5) 1%cholesterol, G6) 1% cholesterol plus 100mg/kg, G7) 1% cholesterol plus 200mg/kg, G8) 1% cholesterol plus 400mg/kg, In experiment 2, diets G5, G6, G7 and G8a diet of 1% cholesterol were fed stock diet for 4-week pre experimental period . The blood and liver tissue samples for serum lipid profile were collected and HMG COA reductase activities determined. Results: P. harmala decreased plasma cholesterol in cholesterol fed rats (100,200,400) mg/kg of the Extract, but decreased plasma triglycerides only in 200,400 mg/kg of the diet group. Peganum harmala supplementation decreased very low density lipoprotein cholesterol and increased * Corresponding author. Tel.: +0-000-000-0000 ; fax: +0-000-000-0000 . HMG COA reductase activities: the P. harmala supplementation further decreased these enzyme activities. P. harmala at the 100 mg/kg dose was similarly effective on lipid metabolism but differences was not significantly, but in 400 mg/kg doses increased these enzyme activities was significantly (P>0.05). Conclusions: It is concluded that methanolic extract of P. harmala could be effectively used in rat to optimize serum lipid profile. These results demonstrate that P. harmala increases the effect of excretion cholesterol and not through HMG COA reductase activities inhibition.

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Triterpenes and B-sitosterol from piper betle: isolation, antiplatelet and anti-inflammatory effects

Cited by 43 publications

References 0 publications

A New Hydroxychavicol Dimer from the Roots of Piper betle

A New Hydroxychavicol Dimer from the Roots of Piper betle

Peganum harmala and Piper longum Plant Rubbing Oil Effect on Pain in Small Male Mice

Effect of Peganum harmala L. on lipid metabolism and changes HMGcoA reductase in Hypercholesterolemia-induced male wistar Rat

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