Triterpene Saponins from Tupidanthus calyptratus

Cioffi, Giuseppina; Bellino, Aurora; Pìzza, Cosimo; Venturella, Fabio; N, De Tommasi

doi:10.1021/np000375y

Cited by 12 publications

(11 citation statements)

References 15 publications

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“…We extrapolated data by using a worksheet on Microsoft Excel and then we created the graphs based on the obtained results. 6 The survey we conducted to describe the knowledge rate on ED is simple and fast for the extrapolation of statistical data, and aims to demonstrate that knowledge on the risks associated with the use and abuse of ED is very poor. In order to make this survey more representative it would be advisable hereafter to expand the sample chosen in a longer time, perhaps proposing it in other cities.…”

Section: Methodsmentioning

confidence: 99%

“…The first has stimulating effects, so much so that the side effects deriving from its excessive consumption include the increase in heart rate, blood pressure, and other events related to the excessive vasoconstrictive effect of caffeine. 6 Ginseng, on the other hand, is known for its tonic and adaptogenic properties and is believed to improve athletic performance, stimulate memory, the immune system and improve mood. 7 Gingko biloba, in addition to the antioxidant properties due to the synergistic action of flavonoids and terpenoids of which it is constituted, favors the vascular circulation, improving cerebral blood flow, which enhances the results of cognitive activities.…”

Section: Introductionmentioning

confidence: 99%

“…7 Gingko biloba, in addition to the antioxidant properties due to the synergistic action of flavonoids and terpenoids of which it is constituted, favors the vascular circulation, improving cerebral blood flow, which enhances the results of cognitive activities. 6 Along with these substances, taurine is also a key component of ED, as it improves the ability to perform physical exercise, increasing the resistance to fatigue and enhancing sports results. 8 It has often been erroneously claimed that taurine was an energy stimulant, but in reality it has the opposite action, being involved in inhibiting the excitatory neurons of the brain, which makes it more of a relaxing substance.…”

Section: Introductionmentioning

confidence: 99%

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Statistical survey focused on diffusion and knowledge of energy drinks, conducted in Palermo

et al. 2022

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In recent years energy drinks consumption has increased, due to their ability to improve physical and cognitive performance. Unfortunately, because of poor or incorrect information, people are not always aware of the harmful consequences of these drinks such as obesity, diabetes, hypertension, tachycardia until death. Therefore, we conducted a statistical survey in the Palermo area, submitting a paper questionnaire to 1003 people. Data analysis shows that: only 29% of the audience never consumed energy drinks, while 71% tried them at least once in their life, especially in adolescence; 81% never or rarely drink them, 14% drink them a few times a month, while 5% drink them several times a week. Energy drinks are mostly consumed in disco, sport and study contexts; 93% of respondents are aware of the risks caused by the excessive consumption of them; 91% know that it is not appropriate to associate them with alcohol, but 9% think it is better to mix them; 72% of interviewees know that people should never drink energy drink with alcohol, 13% do it only in the weekend, while 15% think it is appropriate to do whenever they want. In fact, 14% do not believe it is risky to take energy drinks together with alcohol, and 40% do not know whether it is risky or not, while 46% know it can be risky; 45% associate the idea of cigarettes with alcohol and energy drinks. In conclusion, it is appropriate to highlight their risks to prevent some fatal consequences.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Statistical survey focused on diffusion and knowledge of energy drinks, conducted in Palermo

et al. 2022

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“…214 Five new ursane saponins have been reported from Tupidanthus calyptratus, with two new genins 290 and 291. 215 Kudinosides I-P are new ursane saponins from the leaves of Ilex kudincha. 216 Kudinolic acid 292 is the aglycone of kudinosides I-K. Zygophyloside N is another ursane saponin with a new genin 293, from Zygophyllum gaetulum.…”

Section: The Oleanane Groupmentioning

confidence: 99%

Triterpenoids

Connolly¹,

Hill²

2003

Nat. Prod. Rep.

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This review covers the isolation and structure determination of triterpenoids including squalene derivatives, lanostanes, cycloartanes, dammaranes, euphanes, tirucallanes, tetranortriterpenoids, quassinoids, lupanes, oleananes, friedelanes, ursanes, hopanes, fernanes, sipholanes, isomalabaricanes, serratanes and saponins The literature from January to December 2001 is reviewed and 242 references are cited.

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“…Plants of the Schefflera genus are used as folk remedies for the treatment of pain, rheumatic arthritis, fracture, sprains, and lumbago in Asian countries [3]. As a part of our continuing investigations on the Araliaceae plants from the Botanical Garden of Palermo [4], [5], we studied Schefflera fagueti Baill., a plant native of the Seychelles never before investigated from a phytochemical point of view. The present work deals with the isolation and structural elucidation from the aerial parts of S. fagueti, of six new saponins (1 ± 6) (Figs.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Saponins fromSchefflera fagueti

2003

Planta med

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Six new lupane (1 - 4) and oleanane saponins (5 and 6) were isolated from the aerial parts of Schefflera fagueti Baill. (Araliaceae). Their structures were determined by 2D-NMR spectroscopy (DQF-COSY, 1D-TOCSY, 2D-HOHAHA, 1D-ROESY, HSQC, HMBC). The antiproliferative activity of compounds 1 - 6 and of their prosapogenins (1a - 6a) was evaluated using three continuous murine and human culture cell lines J774, HEK-293, WEHI-164. Oleanane saponins 5 and 6 were the most active, showing significant inhibitory effects on all cell lines, while their prosapogenins 5a and 6a demonstrated minor activity.

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Triterpene Saponins from Tupidanthus calyptratus

Abstract: Five new bisdesmosidic saponins (1--5) were isolated from the aerial parts of Tupidanthus calyptratus. Their structures were determined by (1)H--(1)H correlation spectroscopy (COSY, TOCSY, ROESY) and (1)H--(13)C correlation (HSQC, HMBC) NMR experiments, FABMS, and chemical data.

Cited by 12 publications

References 15 publications

Statistical survey focused on diffusion and knowledge of energy drinks, conducted in Palermo

Statistical survey focused on diffusion and knowledge of energy drinks, conducted in Palermo

Triterpenoids

Cytotoxic Saponins fromSchefflera fagueti

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