Triterpene glycosides ofSapindus mukorossi

Chirva, V. Ya.; Kintya, P. K.; Sosnovskii, V. A.

doi:10.1007/bf00595102

Cited by 2 publications

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“… 11 – 14 A survey of the chemical literature reveals that a great deal of phytochemical work on different parts – fruit, pericarp, seeds, leaves, ripe fruit, roots, and stems – of S. mukorossi, S. saponaira, S. trifoliatus , etc, has been carried out. 15 , 16 Chemically, the fruit of S. mukorossi is valued for the saponins. The present study was designed to assess the hepatoprotective effect of separated and purified S. mukorossi saponin fraction.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of protective effect of Sapindus mukorossi saponin fraction on CCl4-induced acute hepatotoxicity in rats

Rao¹,

Asad²,

Fazil³

et al. 2012

CEG

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AimThis investigation aimed to assess the hepatoprotective effect of saponin fraction isolated from the fruit pericarp of Sapindus mukorossi on carbon tetrachloride (CCl4)-induced hepatotoxicity.MethodsFruit of S. mukorossi was collected and authenticated, and dried pericarp powder subjected to extraction with cold ethanol (70%) by maceration followed by isolation of total saponin fraction. Hepatoprotective activity was demonstrated in the CCl4-damaged primary monolayer culture. In in vivo studies, pretreatment with total saponin fraction (50,100 and 150 mg/kg per os once a day for 4 days before CCl4 introduction and continued afterward for 3 days) attenuated the CCl4-induced acute increase in serum glutamic pyruvic transaminase, serum glutamic oxaloacetic transaminase, and alkaline phosphatase activities and considerably reduced histopathological alterations. Further, saponin fraction reduced thiopentone-induced (4 mg/kg, intraperitoneal) sleeping time in rats.ResultsSaponin fraction pretreatment improves bromsulphalein clearance and also increases cellular viability. Saponin administration replenished depleted hepatic glutathione and superoxide dismutase by improving the antioxidant status of the liver and liver function enzymes. These effects substantiate protection of cellular phospholipids from peroxidative damage induced by highly reactive toxic intermediate radicals formed during biotransformation of CCl4.ConclusionThe above findings lead to the conclusion that the saponin fraction of S. mukorossi has a protective capability both in vitro on primary hepatocyte cultures and in vivo in a rat model of CCl4-mediated liver injury. Hence, we suggest that the inclusion of this S. mukorossi fruit pericarp in the management of liver disorders is justified.

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Section: Introductionmentioning

confidence: 99%