Triterpene glycosides of the leaves ofFatsia japonica. Structure of fatsiosides D, E, and F

Kemoklidze, Z. S.; Dekanosidze, G. E.; Dzhikiya, O. D.; Vugal'ter, M. M.; Кемертелидзе, Э. П.

doi:10.1007/bf00579501

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“…(Araliaceae) is an evergreen plant growing in the regions around Black Sea [1,2]. By Institute of Pharmacochemistry (TSMU) from the ethanolic extract of the leaves of Fatsia japonica was obtained purified fraction of triterpene glycosides ("Fatsiflogin") which possesses antirheumatic, anti-inflammatory and analgesic activities and is an original, nonsteroidal para-medical preparation [3,4,5,6 ].Five triterpene glycosides (Fatsiosides) were identified in "Fatsiflogin".Fatsioside D (tetraosid of hederagenin-bidesmoside) as one of the major compound of "Fatsiflogin", was selected as a chemical marker [8,9] for the quantitative validation of "Fatsiflogin".The aim of this study was the development of analytical procedures for the quantitative validation of "Fatsiflogin".…”

Section: Introductionmentioning

confidence: 99%

Development of Analytical Procedure for the Quantification of “Fatsiflogin”

Getia¹,

Mshvildadze²,

Pichette³

et al. 2017

IOSRPHR

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:"Fatsiflogin" is an original, nonsteroidal para-medical preparation from the leaves of Fatsia japonica with anti-rheumatic, anti-inflammatory and analgesic activities. Fatsioside D (tetraosid of hederagenin) as one of the major compound of "Fatsiflogin", was selected as a chemical markerfor the quantitative validation. The objective of this study is to develop a simple and reliable HPLC method for the determination of Fatsiosid D for quality control studies of "Fatsiflogin". FatsiosideD was purified by preparative HPLC and the structure of the compound was determined by NMR. HPLC separation was performed on an intertsil prep-ODS C18 column, with a solvent system water-acetonitrile. The UV detection is performed at 205 nm. The proposed HPLC method is linear in the range studied (r 2 > 0.999) for all the analytes. The method is precise with intra-and inter-day variations of less than 3.34%. The mean recoveries of the analytes range from 99.68 to 100.29%. The method is successfully applied to the quantification of Fatsioside D. The results indicated that developed HPLC method could be used for the quality control of "Fatsiflogin".

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Section: Introductionmentioning

confidence: 99%