Triterpene glycosides from Astragalus and their genins. XCIII. Cycloascidoside from Astragalus mucidus

Naubeev, T. Kh.; Zhanibekov, A. A.; Исаев, М. И.

doi:10.1007/s10600-012-0390-2

Cited by 5 publications

(3 citation statements)

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“…As the summarized results shown in Table 1, Table 2 and Table 3 and Figure 1, Figure 2, Figure 3 and Figure 4, 46 kinds of Astragalus species have been studied for their chemical constituents in recent years [9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,…”

Section: Phytochemistrymentioning

confidence: 99%

“…Commonly, the aglycon of cycloartane-type saponins such as 1 – 62 possess an acyclic side chain at the 17-position. For the 17-acyclic side chain substituted cycloartane-type saponins, obtained from the Astragalus genus, the 24-position is often replaced by oxygen containing groups, and there are two kinds of steric configuration constituents with 24 S ( 1 – 28 ) [6,9,10,11,12,13,14,15,16,17,18,19,20,21,22] or 24 R ( 29 – 48 ) [7,14,15,16,17,23,24,25,26,27,28,29,30,31,32,33,34].…”

Section: Phytochemistrymentioning

confidence: 99%

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A Review of Recent Research Progress on the Astragalus Genus

Li¹,

Qu²,

Dong³

et al. 2014

Molecules

238

148

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Astragalus L., is one of the largest genuses of flowering plants in the Leguminosae family. Roots of A. membranaceus Bge. var. mongholicus (Bge.) Hsiao, A. membranaceus (Fisch.) Bge. and its processed products are listed in the China Pharmacopeia for "qi deficiency" syndrome treatment. However, more and more researches on other species of Astragalus have been conducted recently. We summarize the recent researches of Astragalus species in phytochemistry and pharmacology. More than 200 constituents, including saponins and flavonoids, obtained from 46 species of Astragalus genus were collected for this article. In pharmacological studies, crude extracts of Astragalus, as well as isolated constituents showed anti-inflammatory, immunostimulant, antioxidative, anti-cancer, antidiabetic, cardioprotective, hepatoprotective, and antiviral activities. The goal of this article is to provide an overview of chemical and pharmacological studies on the Astragalus species over the last 10 years, which could be of value to new drug or food supplement research and development. OPEN ACCESS

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Section: Phytochemistrymentioning

confidence: 99%

Section: Phytochemistrymentioning

confidence: 99%

A Review of Recent Research Progress on the Astragalus Genus

Li¹,

Qu²,

Dong³

et al. 2014

Molecules

238

148

View full text Add to dashboard Cite

show abstract

“…There are around 170 saponins of the cycloartane‐ and the oleanane type. Astragalosides are the main cyloartane‐type saponins, with astragaloside IV (Figure 1) as the quality control biomarker (Naubeev, Zhanibekov, & Isaev, 2012). Astragaloside IV possesses antioxidative, antiaging, antiinflammatory, antiasthma, antidiabetes, and antiatherosclerosis activities, as well as cardioprotective and neuroprotective effects (Costa et al, 2019; Gong et al, 2018; Li, Hou, Xu, Liu, & Tu, 2017; Wen et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Astragalus species: Insights on its chemical composition toward pharmacological applications

Salehi

Carneiro

Rocha

et al. 2020

Phytotherapy Research

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Astragalus L. is widely distributed throughout the temperate regions of Europe, Asia, and North America. The genus is widely used in folk medicine and in dietary supplements, as well as in cosmetics, teas, coffee, vegetable gums, and as forage for animals.The major phytoconstituents of Astragalus species with beneficial properties are saponins, flavonoids, and polysaccharides. Astragalus extracts and their isolated components exhibited promising in vitro and in vivo biological activities, including antiaging, antiinfective, cytoprotective, antiinflammatory, antioxidant, antitumor, antidiabesity, and immune-enhancing properties. Considering their proven therapeutic potential, the aim of this work is to give a comprehensive summary of the Astragalus spp. and their active components, in an attempt to provide new insight for further clinical development of these xenobiotics. This is the first review that briefly describes their ethnopharmacology, composition, biological, and toxicological properties.

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