Triterpene alcohols from the flowers of compositae and their anti-inflammatory effects

Akihisa, Toshihiro; Yasukawa, Ken; Oinuma, Hirotoshi; Kasahara, Yoshiyuki; Yamanouchi, Sakae; Takido, Michio; Kumaki, Kunio; Tamura, Toshitake

doi:10.1016/s0031-9422(96)00343-3

Cited by 236 publications

(179 citation statements)

References 14 publications

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“…These results suggested that the effect of compound 1 on B16 2 F2 cells might not be cytotoxic but cytostatic. Lupane is one of the major triterpenes in Compositae plants and its biological activities have been reported (Akihisa et al 1996;Saleem et al 2004); however, there have been no reports concerning the differentiation-inducing activity of lupane triterpenes on tumor cells. Therefore, we studied the actions of lupane triterpenes on melanoma cells in more detail.…”

Section: Isolation Of Melanogens From Compositae Plantsmentioning

confidence: 99%

Differentiation-inducing activity of lupane triterpenes on a mouse melanoma cell line

et al. 2006

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Lupane triterpenes were found to promote melanogenesis, a hallmark of B16 2F2 mouse melanoma cell differentiation. Studies of the structureactivity relationships demonstrated that the keto function at C-3 of the lupane skeleton played important roles in the melanogenic activities of lupane triterpenes on melanoma cells. The carbonyl group at C-17 of lupane triterpenes was essential against their apoptosis-inducing activity against human cancer cells via the inhibition of topoisomerase I. We investigated whether signaling mechanisms were involved in the stimulative effects of lupane triterpenes on the melanogenesis of B16 2F2 cells. In experiments using selective inhibitors against various signal transduction molecules and Western blotting analysis, it was suggested that p38 MAPK was involved in melanoma cell differentiation as a downstream effector of PKA. Lupeol (compound 1), a lupane triterpene, induced dendrite formations, a morphological hallmark of B16 2F2 cell differentiation by rearrangement of the actin cytoskeleton.The activation of cofilin, an actin depolymerizing factor, by compound 1 caused actin fiber disassembly in B16 2F2 cells. Furthermore, compound 1 was shown to inhibit the cell motilities of human melanoma and neuroblastoma in vitro.

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Section: Isolation Of Melanogens From Compositae Plantsmentioning

confidence: 99%

Differentiation-inducing activity of lupane triterpenes on a mouse melanoma cell line

et al. 2006

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“…Recently, several reports have suggested that petals of edible chrysanthemum flowers, such as Chrysanthemum×morifoli-um Ramat., contain various physiologically active substances (Takahashi et al, 1978;Akihisa et al, 1997). Although petals of edible chrysanthemum flowers cultivated in Japan have a relatively high content of flavonoids (Tateyama et al, 1997), there have been few reported cases in which flavonoids were contained.…”

Section: Introductionmentioning

confidence: 99%

Identification of Major Flavonoids in Petals of Edible Chrysanthemum Flowers and Their Suppressive Effect on Carbon Tetrachloride-Induced Liver Injury in Mice

Sugawara

Igarashi

2009

FSTR

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“…Calendulae flos is a complex mixture including essential oils, glycosides, saponins, triols, and xanthophylls, with the triterpenoids being the most important anti-inflammatory principles (Delia Loggia et al 1994). Calendulae flos has been used historically as a traditional medicine and food dye (Khodzhaeva & Turakhozhaev 1993), but is currently being increasingly used as an external anti-inflammatory and wound healer (Bissett 1994;Akihisa et al 1996;Patrick et al 1996). This has prompted investigation of the potential for calendula flower production and processing in New Zealand.…”

Section: Introductionmentioning

confidence: 99%

Effect of plant population on calendula (Calendula officinalisL.) flower production

Martin¹,

Deo²

2000

New Zealand Journal of Crop and Horticultural Science

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Calendula (Calendula officinalis L.) was drilled at 3, 6, 12, 24, 48, and 96 kg seed/ha in a trial at Lincoln, New Zealand, in November 1997. Plots were divided into five equally sized sections. Fully open flowers were harvested from Sections 2 and 4 of all plots twice or three times weekly from early February to mid March 1998, after which plant population and crop biomass were determined from the same sections and seed yield/flower determined from Sections 1, 3, and 5. Plant counts increased from 9 plants/m 2 at the 3 kg seed/ha rate, to 26 at 6, 46 at 12, 101 at 24, 179 at 48, and 332 plant/m 2 at 96 kg seed/ha. Total flower yield was not significantly different at populations over 46 plants/m 2 , but declined with lower plant populations. The total fresh weight (and number) of fully opened flower heads collected off each plot increased from 0.5 (164)

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Triterpene alcohols from the flowers of compositae and their anti-inflammatory effects

Cited by 236 publications

References 14 publications

Differentiation-inducing activity of lupane triterpenes on a mouse melanoma cell line

Differentiation-inducing activity of lupane triterpenes on a mouse melanoma cell line

Identification of Major Flavonoids in Petals of Edible Chrysanthemum Flowers and Their Suppressive Effect on Carbon Tetrachloride-Induced Liver Injury in Mice

Effect of plant population on calendula (Calendula officinalisL.) flower production

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