Tristetraprolin (TTP) gene polymorphisms in patients with rheumatoid arthritis and healthy individuals

Suzuki, Takeshi; Tsutsumi, Akito; Suzuki, Hiroyuki; Suzuki, Eiji; Sugihara, Makoto; Muraki, Yoshifumi; Hayashi, Taichi; Chino, Yusuke; Goto, Daisuke; Matsumoto, Isao; Ito, Satoshi; Miyazawa, Keiji; Sumida, Takayuki

doi:10.3109/s10165-008-0085-5

Cited by 18 publications

(14 citation statements)

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“…Alternatively, the presence of this SNP could influence transcription or the stability of TTP mRNA [96]. More recently a single nucleotide polymorphism (SNP359A->G) was identified within the promoter region of TTP [97]. The functional consequence of this SNP was demonstrated to impact TTP promoter activity with the presence of the G allele resulting in approximately a 2-fold decrease in TTP promoter activity [97].…”

Section: The Role Of Tis11 Family Members In Diseasementioning

confidence: 99%

“…More recently a single nucleotide polymorphism (SNP359A->G) was identified within the promoter region of TTP [97]. The functional consequence of this SNP was demonstrated to impact TTP promoter activity with the presence of the G allele resulting in approximately a 2-fold decrease in TTP promoter activity [97]. Although no significant differences were observed in the allele frequencies of SNP359A->G between healthy individuals and RA patients, a trend, although not statistically significant, was observed in patients with the GG genotype to have a younger age of disease onset compared to those with genotypes AA/AG [97].…”

Section: The Role Of Tis11 Family Members In Diseasementioning

confidence: 99%

“…The functional consequence of this SNP was demonstrated to impact TTP promoter activity with the presence of the G allele resulting in approximately a 2-fold decrease in TTP promoter activity [97]. Although no significant differences were observed in the allele frequencies of SNP359A->G between healthy individuals and RA patients, a trend, although not statistically significant, was observed in patients with the GG genotype to have a younger age of disease onset compared to those with genotypes AA/AG [97]. These findings indicate that this SNP could possibly modulate disease activity of RA due to a subtle defect in the promoter activity of ZFP36 leading to attenuation of TTP expression on a transcriptional level.…”

Section: The Role Of Tis11 Family Members In Diseasementioning

confidence: 99%

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The roles of TTP and BRF proteins in regulated mRNA decay

2010

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AU-rich element (ARE) motifs are cis-acting elements present in the 3′UTR of mRNA transcripts that encode many inflammation-and cancer-associated genes. The TIS11 family of RNA-binding proteins, composed of TTP, BRF-1, and BRF-2 play a critical role in regulating the expression of ARE-containing mRNAs. Through their ability to bind and target ARE-containing mRNAs for rapid degradation, this class of RNA-binding proteins serves a fundamental role in limiting the expression of a number of critical genes, thereby exerting anti-inflammatory and anti-cancer effects. Regulation of TIS11 family members occurs on a number of levels through cellular signaling events to control their transcription, mRNA turnover, phosphorylation status, cellular localization, association with other proteins, and proteosomal degradation, all of which impact TIS11 members' ability to promote ARE-mediated mRNA decay along with decay-independent functions. This review summarizes our current understanding of post-transcriptional regulation of ARE-containing gene expression by TIS11 family members and discuss their role in maintaining normal physiological processes and the pathological consequences in their absence. KeywordsTristetraprolin; Butyrate Response Factor; AU-rich element; mRNA decay; post-transcriptional regulation Messenger RNA turnover is a tightly regulated process that is critical in controlling mammalian gene expression. The importance of this level of regulation is evident in a variety of diseases where loss of post-transcriptional gene regulation directly contributes to the overexpression of many genes encoding growth factors, inflammatory cytokines, and proto-oncogenes [1,2]. A characteristic feature present within the 3′ untranslated region (3′UTR) of these mRNAs is the adenylate-and uridylate (AU)-rich element (ARE). The significance of this conserved cis-acting RNA element is apparent in its frequency since it is currently estimated that approximately 8% of the human transcriptome contains AREs [3]. A primary function of the ARE is to target specific mRNAs for rapid decay through interaction with trans-acting RNA-binding proteins. Initially discovered in 1989 [4], the tristetraprolin (TTP) protein and its related family members butyrate response factors 1 and 2 (BRF-1 and * Correspondence: Dan A. Dixon, Department of Biological Sciences and Cancer Research Center, University of South Carolina, 712 Main St., Jones Physical Sciences Center, Room 614, Columbia, SC 29208, ddixon@biol.sc.edu, Tel: 803-777-4686; Fax: 803-777-1173 . Cross-ReferencesOverview -RNA decay as a major mediator of gene expression and QC Overview -RNA decay in bacteria and eukaryotes Cis acting elements that regulate mRNA decay Networking between mRNA decay and other cellular processes RNA-binding domains-Zn-F Mechanisms of deadenylation-dependent decay Stress granules and P bodies NIH Public Access Author ManuscriptWiley Interdiscip Rev RNA. Author manuscript; available in PMC 2011 January 28. NIH-PA Author ManuscriptNIH-PA Author Manuscript ...

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Section: The Role Of Tis11 Family Members In Diseasementioning

confidence: 99%

Section: The Role Of Tis11 Family Members In Diseasementioning

confidence: 99%

Section: The Role Of Tis11 Family Members In Diseasementioning

confidence: 99%

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The roles of TTP and BRF proteins in regulated mRNA decay

2010

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“…We are not aware of any functional polymorphisms, mutations, or alternatively-spliced isoforms of PARP-14 in either mouse or human, but polymorphisms in the promoter and coding regions of TTP in humans have been linked to TTP expression levels and may influence risk or severity of cancer and inflammatory disorders such as rheumatoid arthritis. [48][49][50] In conclusion, our study establishes posttranscriptional regulation of TF mRNA as an important level of control of TF expression and raises the question as to what degree altered expression of TF in disease states relates to dysfunctional control of mRNA stability. We have discovered interactions between PARP-14, a new protein in posttranscriptional regulation, and TTP, an established protein (D-E) TF activity was measured in lung tissue and peripheral blood leukocytes using a turbimetric clotting assay (n 5 6-8 mice per group).…”

Section: Org Frommentioning

confidence: 99%

PARP-14 combines with tristetraprolin in the selective posttranscriptional control of macrophage tissue factor expression

Iqbal

Johns

Cao

et al. 2014

Blood

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“…Between the two-genotype groups of rs17879933, BMI, SBP, DBP, UA, and TNF-α levels were significantly different, and the rs17879933 II genotype had higher values than the rs17879933 DD + ID genotype. Suzuki et al (2008) identified an SNP, namely SNP359 A/G (ZFP36 rs251864), within the ZFP36 promoter region that impacted promoter activity. Although no differences were observed in the allele frequencies of SNP359 A/G between healthy individuals and rheumatoid arthritis patients, the presence of the minor G allele inhibited ZFP36 promoter activity by approximately twofold compared with the A allele.…”

Section: Discussionmentioning

confidence: 99%

Relationship between zinc finger protein 36 (ZFP36) gene polymorphisms and obstructive sleep apnea

Zhang

Abulikemu

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Recent data have indicated that inflammation may have an important correlation with obstructive sleep apnea (OSA). Studies have indicated a relationship between OSA and TNF-α gene polymorphisms. Zinc finger protein 36 (ZFP36) regulates TNF-α mRNAs. However, ZFP36 gene polymorphisms have not been investigated in OSA. Therefore, we conducted the present case-control study to assess whether variances in ZFP36 gene polymorphisms account for differences in TNF-α levels in patients with moderate-tosevere OSA. This case-control study aims to investigate the relationship between genetic variations in the ZFP36 gene and moderate-to-severe OSA. Three common single nucleotide polymorphisms of the ZFP36 gene (rs251864, rs3746083, and rs17879933) were evaluated in a group of patients with moderate-to-severe OSA (N = 408) and in a control Y. Zhang et al. 6734©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (2): 6733-6743 (2015) group (N = 394) by using TaqMan polymerase chain reaction analysis. The moderate-to-severe OSA group and the control group exhibited significant differences in the distributions of rs251864 and rs17879933 genotypes and alleles (P < 0.05). TNF-α levels were significantly different not only among the three rs251864 genotypes but also between the II genotype and the DD + ID genotypes of rs17879933. However, no significant differences in sleep apnea parameters in the three ZFP36 gene polymorphisms were observed. Logistic regression analyses demonstrated that TNF-α and the three ZFP36 gene polymorphisms were not independently associated with OSA. ZFP36 might be involved in TNF-α regulation. However, ZFP36 gene variants were not independent risk factors for moderate-to-severe OSA.

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Tristetraprolin (TTP) gene polymorphisms in patients with rheumatoid arthritis and healthy individuals

Cited by 18 publications

References 9 publications

The roles of TTP and BRF proteins in regulated mRNA decay

The roles of TTP and BRF proteins in regulated mRNA decay

PARP-14 combines with tristetraprolin in the selective posttranscriptional control of macrophage tissue factor expression

Relationship between zinc finger protein 36 (ZFP36) gene polymorphisms and obstructive sleep apnea

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