Tristetraprolin Mediates Interferon-γ mRNA Decay

TGF-β Decreases the Stability of IL-18-Induced IFN-γ mRNA through the Expression of TGF-β-Induced Tristetraprolin in KG-1 Cells

“…46) Very recently, TTP was also reported to regulate the expression of IFN-γ mRNA. 47) In the present study, we showed that TGF-β induces the expression of TTP mRNA, which is consistent with previous reports. 31) Because the TGF-β-deficient mice exhibit a quite similar phenotype with TTP-deficient mice, it is intriguing to speculate that the anti-inflammatory responses of TGF-β may be, at least partly, caused by TGF-β induced TTP.…”

Breakdown in Repression of IFN-γ mRNA Leads to Accumulation of Self-Reactive Effector CD8+ T Cells

“…The present work identifies IFN-g as a novel target of Roquin sanmediated repression. IFN-g is a cytokine known to be regulated posttranscriptionally: the RNA-binding protein tristetraprolin was reported to destabilize IFN-g mRNA (43). Accumulation of Ifng mRNA causes excessive production of IFN-g, which acts, at least in part, to promote the expansion and accumulation of KLRG1 lo and terminally differentiated effector CD8 + T cells in Roquin san/san mice.…”

MK2 posttranscriptionally regulates TNF-α-induced expression of ICAM-1 and IL-8 via tristetraprolin in human pulmonary microvascular endothelial cells

“…The best studied destabilizing factor is tristetraprolin (TTP), which has been shown to bind to the AREs of TNF-␣ mRNA and promote TNF-␣ mRNA deadenylation and degradation in HEK 293 cells (13). Several other studies have investigated the role of TTP in promoting destabilization of IL-8, interferon-␥ (IFN-␥), and vascular endothelial growth factor (VEGF) mRNAs in different cell lines (2,16,23).…”