Tristetraprolin, Inflammation, and Metabolic Syndrome in Arab Adults: A Case Control Study

Abstract

Tristetraprolin (TTP) is an mRNA binding protein suggested to have a substantial role in regulating the mRNA expression of numerous inflammatory factors, but data on TTP and its association with metabolic syndrome (MetS), a chronic low-grade inflammatory disorder, are scarce. We hypothesize that TTP may modulate MetS and its components. A total of 200 Saudi adults (aged 38.6 ± 8.3 years) were included in this cross-sectional study. Anthropometrics data were collected and fasting blood glucose taken for the assessment of glycemic, lipids and inflammatory markers using commercially available assays. The National Cholesterol Education Program Adult Treatment Panel (NCEP ATP III) criteria were used to define MetS. Results showed significantly higher levels of TTP in the MetS group than in controls [288.1 pg/mL vs. 150.9 pg/mL, p < 0.001]. Circulating TTP was significantly associated with tumor necrosis factor alpha [TNF-α, R = 0.30, p < 0.05], interleukin 1β [IL-1β, R = 0.41, p < 0.01] and C-reactive protein [CRP, R = 0.36, p < 0.01], adiponectin [R = 0.36, p < 0.05], insulin [R = 0.37, p < 0.05], and insulin resistance [HOMA-IR, R = 0.40, p < 0.05]. Receiver operating characteristics (ROC) suggest a potential use of TTP as diagnostic biomarker for MetS [AUC = 0.819, p < 0.001]. The findings suggest that TTP is associated with inflammation and glycemia, which may influence MetS. TTP is a promising diagnostic biomarker for MetS which can be confirmed in larger cohorts.

Association between Metabolic Syndrome Components and Serum High-Sensitivity C-Reactive Protein or Interleukin-6 Levels among Congolese Adults

“…We found also significant differences between males and females in serum hs-CRP and IL-6 levels among Congolese adults. Previous studies have reported gender differences in circulating hs-CRP and IL-6 levels, while Al-Daghri et al [24] and Zafar et al [25]. According to the present study, there was a significant correlation between hs-CRP and fasting TG in both gender.…”

Correlation of White Blood Cell, Neutrophils, and Hemoglobin with Metabolic Syndrome and Its Components

“…Previous studies indicated MetS was related to inflammation responses. 24 , 25 In terms of WBC, neutrophils, and NLR as hematological indicators for MetS, the results were not consistent. The present study revealed that the MetS individuals had high level of WBC and neutrophils than non-MetS individuals.…”

Angiogenin Levels and Their Association with Cardiometabolic Indices Following Vitamin D Status Correction in Saudi Adults

“…Serum triglycerides ≥ 1.7 mmol/L was considered high [ 21 ]. Low HDL-cholesterol was defined as < 1.03 mmol/L in men and < 1.3 mmol/L in women [ 21 , 22 ]. Serum 25 (OH) vitamin D was determined using the LIAISON XL automated quantitative analyzer (DiaSorin, Saluggia, Italy).…”