Trisomy 21 in patients with acute leukemia

Cheng, Yi‐Kan; Wang, Huafeng; Wang, Huanping; Chen, Zhimei; Jin, Jie

doi:10.1002/ajh.21339

Cited by 13 publications

(10 citation statements)

References 8 publications

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“…This bias can progress to a transient myeloproliferative disorder (TMD) (Gamis and Smith 2012) and eventually AML if a cooperating GATA1 mutation is also present (Hitzler 2003;Mundschau et al 2003). Furthermore, trisomy 21 is also observed in non-DS hematologic cancers (Mitelman et al 1990;Cheng et al 2009). The model system that we developed here will permit effective molecular dissection of the effect of specific chromosomal abnormalities and the role of aneuploidy and CIN in general on the development of leukemias and lymphomas.…”

Section: H/hmentioning

confidence: 99%

Aneuploidy impairs hematopoietic stem cell fitness and is selected against in regenerating tissues in vivo

et al. 2016

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Aneuploidy, an imbalanced karyotype, is a widely observed feature of cancer cells that has long been hypothesized to promote tumorigenesis. Here we evaluate the fitness of cells with constitutional trisomy or chromosomal instability (CIN) in vivo using hematopoietic reconstitution experiments. We did not observe cancer but instead found that aneuploid hematopoietic stem cells (HSCs) exhibit decreased fitness. This reduced fitness is due at least in part to the decreased proliferative potential of aneuploid hematopoietic cells. Analyses of mice with CIN caused by a hypomorphic mutation in the gene Bub1b further support the finding that aneuploidy impairs cell proliferation in vivo. Whereas nonregenerating adult tissues are highly aneuploid in these mice, HSCs and other regenerative adult tissues are largely euploid. These findings indicate that, in vivo, mechanisms exist to select against aneuploid cells.

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Section: H/hmentioning

confidence: 99%

Aneuploidy impairs hematopoietic stem cell fitness and is selected against in regenerating tissues in vivo

et al. 2016

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“…There is prognostic ambiguity with regard to the prognostic significance of this acquired trisomy. In literature search, Cheng et al [2] has clearly stated the poor prognosis imparted by the presence of trisomy 21 in ALL. Though this observation remains ambiguous as Atlas of genetics and cytogenetics in oncology and hematology reports trisomy 21 to confer a better overall survival when exist as a sole cytogenetic abnormality in childhood ALL; its role in adult ALL remains undetermined.…”

Section: Discussionmentioning

confidence: 99%

“…Trisomy 21 is considered to be acquired when the phenotypic features pertinent to down syndrome are absent. There is proven enhanced leukemogenic potential in constitutional down syndrome [2]. The role of acquired trisomy 21 is relatively well documented in cases of B-cell ALL, but there is no such defined role in T-cell ALL.…”

Section: Introductionmentioning

confidence: 99%

Acquired Trisomy 21 - A Unique Cytogenetic Finding in T-Cell Acute Lymphoblastic Leukemia

Rizvi¹,

Jamal²,

Hassan³

et al. 2017

Natl. j. health sci.

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Acute lymphoblastic leukemia (ALL), is a lymphoid neoplasm arising from lymphoid progenitors, broadly classified according to lineage into B-cell and T-cell ALL in which T-cell ALL constitutes a small proportion. We are reporting here a case of young female who was diagnosed as T-cell ALL using flow cytometry with acquired trisomy 21, identified on conventional cytogenetics, as a unique finding in this case.

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“…Individu-als with Down syndrome display an increased incidence of acute lymphoblastic leukemia and acute myeloid leukemia (Satge et al 1998), especially in childhood. Trisomy of chromosome 21 is also frequently observed as an acquired abnormality in hematological cancers, including a subtype of AML (Mitelman et al 1990;Hama et al 2008;Cheng et al 2009). These observations suggest that chromosome 21 may contain oncogenes whose amplification drive the development of blood cancers.…”

Section: Aneuploidy As a Driver Of Tumorigenesismentioning

confidence: 99%

Aurea Mediocritas: The Importance of a Balanced Genome

Varetti

Pellman

Gordon

2014

Cold Spring Harbor Perspectives in Biology

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Aneuploidy, defined as an abnormal number of chromosomes, is a hallmark of cancer. Paradoxically, aneuploidy generally has a negative impact on cell growth and fitness in nontransformed cells. In this work, we review recent progress in identifying how aneuploidy leads to genomic and chromosomal instability, how cells can adapt to the deleterious effects of aneuploidy, and how aneuploidy contributes to tumorigenesis in different genetic contexts. Finally, we also discuss how aneuploidy might be a target for anticancer therapies.

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Trisomy 21 in patients with acute leukemia

Cited by 13 publications

References 8 publications

Aneuploidy impairs hematopoietic stem cell fitness and is selected against in regenerating tissues in vivo

Aneuploidy impairs hematopoietic stem cell fitness and is selected against in regenerating tissues in vivo

Acquired Trisomy 21 - A Unique Cytogenetic Finding in T-Cell Acute Lymphoblastic Leukemia

Aurea Mediocritas: The Importance of a Balanced Genome

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