Trisomy 21 (Down Syndrome) Incidence Dynamics in the Regions of the Russian Federation in 2011–2017

Демикова, Н. С.; Podolnaya, M.A.; Lapina, A.; Володин, Н. Н.; Asanov, A. Yu.

doi:10.24110/0031-403x-2019-98-2-42-48

Cited by 4 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…В соответствии с приказом Минздрава России № 572н от 01.11.2012 1 все женщины при сроке беременности от 11 до 14 недель в условиях учреждения экспертного уровня подлежат пренатальному скринингу, включающему анализ клинико-анамнестических данных беременной, ультразвуковое исследование плода, определение уровня сывороточных маркеров (связанного с беременностью плазменного протеина А (РАРР-А) и хорионического гонадотропина (β-ХГЧ)) и программный комплексный расчет индивидуального риска рождения ребенка с анеуплоидией. Однако пренатальная диагностика трисомии по 13, 18 или 21-й хромосоме при данном подходе не превышает 84 % [4], поэтому необходима разработка новых 1 Приказ Министерства здравоохранения РФ от 1 ноября 2012 г. № 572н «Об утверждении Порядка оказания медицинской помощи по профилю "акушерство и гинекология (за исключением использования вспомогательных репродуктивных технологий)"».…”

Section: Introductionunclassified

Non-invasive prenatal screening: experience in the Republic of Tyva

Gritsinskaya

Людвиговна²,

Sanchat³

et al. 2020

Pediatr (SPb)

View full text Add to dashboard Cite

Diagnosis of congenital developmental anomalies and chromosomal abnormalities of the intrauterine fetus in early pregnancy can reduce infant mortality rates.The purpose of research:to evaluate the first results of the non-invasive prenatal test (NIPT) in the Republic of Tyva.Materials and methods.A retrospective analysis of the reports of the Federal State Statistics Service for the Republic of Tyva, the Ministry of Health and the Tyva Perinatal Center was carried out; monitoring data of congenital developmental anomalies in the republican medical genetic center.Results.Analysis of infant mortality in the Republic of Tuva for the period from 2000 to 2019 showed that with a steady decline in indicators (29.97.3), itslevel significantly exceeds the national average. One of the leading causes of infant mortality in the republic is congenital malformations, the frequency of which among newborns in Tuva is 12.633.4. Diseases caused by chromosome abnormalities make up from 4.3% to 1.2% in the structure of congenital malformations. In recent years, the number of women who underwent fetal pathology screening in the first trimester of pregnancy has been increasing in the republic (56.262.1%). According to combined screening, the detection of major chromosomal aneuploidies (Down, Edwards andPatau syndromes) is 2.16.6%. In all cases of positive screening, NIPT was performed, which has a higher specificity and sensitivity; the presence of chromosomal aberrations in the fetus was confirmed in 98.199.5% of cases.Conclusion.The introduction of widespread use of NIPT in the republic will increase the efficiency of detecting chromosomal abnormalities, reduce the number of invasive diagnostic interventions, avoid unjustified termination of pregnancy and reduce infant mortality.

show abstract

Section: Introductionunclassified

Non-invasive prenatal screening: experience in the Republic of Tyva

Gritsinskaya

Людвиговна²,

Sanchat³

et al. 2020

Pediatr (SPb)

View full text Add to dashboard Cite

show abstract

The Dynamic of the Fertility Age Model in the Two Regions of Russia

2022

View full text Add to dashboard Cite

Introduction. The increase of the age of mothers at the birth of children is observed in the modern period. The speed of this process in different regions of Russia and the world is different. The aim of this research is to estimate the average age of mothers and the number of children born by one woman in Tyumen and Petropavlovsk-Kamchatsky in 2017–2018. Materials and Methods. The archival documents from medical institutions about 676 women who registered for pregnancy have been analyzed. For temporary comparison for the period from 1985 to 2003, we use the data presented in a previously published monograph. The standard methods of statistics, spatial and temporal analysis are used, which have made it possible to identify the dynamics of the age model of fertility. Results. The authors have determine that the distribution of women by age at the birth of children is the same in two Russian cities. A group of women aged 26 to 33 years is represented with 55% frequency. The average age of women in labor from two cities is the same. In Tyumen is 30.1 ± 0.63, in Petropavlovsk-Kamchatsky is 29.5 ± 0.38. The article provides evidence that in the previous period, the proportion of women in labor aged 18 to 25 years was 60%. In both cities, the distribution of women by the number of births is the same, 83% gave birth twice. 14% of children were born in third births. In the previous time interval, 65% of children were born in first birth. During this period it has been defined that the average number of births in the city of Tyumen is less than in the rural areas of the south of the Tyumen region, and less than among the indigenous women in the north of the region (Khanty and Mansi). Discussion and Conclusion. In the studied period, the dynamic of increase of the age of women in labor is obvious. One of the reasons for this trend is the increase count of mothers giving birth again. The financial support from the state makes possible to implement the two-child and large family model in Russia. But it should be aware of the increased risk of biological problems in the group of older women. It is advisable to discuss the negative consequences of delayed motherhood, for example, through the education system. The material of the article is useful, first of all, for future parents.

show abstract

Prevalence of congenital malformations in the Republic of Sakha (Yakutia)

Демикова

Podolnaya

Syromyatnikova

et al. 2022

Ross. vestn. perinatol. pediatr.

View full text Add to dashboard Cite

Purpose. The study aims at assessing and analyzing the prevalence of congenital malformations in the Republic of Sakha (Yakutia) based on the data from birth defects surveillance from 2012 to 2019.Material and methods. The data of congenital malformations monitoring in the Republic of Sakha (Yakutia) for 2012–2019 are analyzed. There were revealed 1104 cases of congenital malformations of obligate registration. The total number of births was 122,413. The prevalence of birth defects was calculated per 10000 births.Results. The prevalence of congenital malformations in the Republic of Sakha was obtained. The analysis of the dynamics of the congenital malformations prevalence has been carried out. No changes in the birth defects prevalence for the analyzed period have been shown.Conclusion. Regional monitoring makes it possible to obtain and analyze congenital malformations prevalence.

show abstract

Trisomy 21 (Down Syndrome) Incidence Dynamics in the Regions of the Russian Federation in 2011–2017

Cited by 4 publications

References 0 publications

Non-invasive prenatal screening: experience in the Republic of Tyva

Non-invasive prenatal screening: experience in the Republic of Tyva

The Dynamic of the Fertility Age Model in the Two Regions of Russia

Prevalence of congenital malformations in the Republic of Sakha (Yakutia)

Contact Info

Product

Resources

About