Trismus

Abstract

Trismus or jaw hypomobility refers to a sustained, tonic spasm of the masticatory muscles. There are various causes for this common symptom where the patient seeks medical intervention immediately, as it impairs speech and eating; causes social injunction leading to fear, anxiety and anger. Successful treatment of trismus depends on prompt recognition of its cause and immediate initiation of appropriate treatment. A thorough knowledge of this hypomobility is essential for successful treatment and to avoid permanent functional disability. This article gives an insight into etiology, differential diagnosis and treatment of trismus. How to cite this article Poornima G, Poornima C. Trismus. J Health Sci Res 2014;5(2):15-20.

Extended Multitarget Pharmacology of Anticancer Drugs

“…With the relatively low success rate of the typical single-target drug discovery paradigm in recent years, multi-target drug and network pharmacology provides a more realistic conceptual framework in both small-molecule cancer therapeutics and other drug development 2,3,14,15,[30][31][32][33] . Our study of cancer drugs revealed that multi-target pharmacology is an expected and inherent property for small-molecule therapeutics.…”

Effect of Total Surgical Time on Patient’s Complaint of Mouth Opening After Transalveolar Removal of Impacted Mandibular Wisdom Teeth- A Randomised, Controlled, Clinical Trial

“…In general, males display greater mouth opening. [2] The aetiology of trismus may be classified as follows: infection; trauma; dental treatment; temporomandibular joint disorders; tumours and oral care; drugs; radiotherapy and chemotherapy; congenital problems; miscellaneous disorders. Amongst all these causes dental treatment, specially dentoalveolar surgeries is the most common cause of trismus.…”

“…Amongst all these causes dental treatment, specially dentoalveolar surgeries is the most common cause of trismus. [2,3] Just like pain and swelling, trismus is a post-surgical inflammatory response that involves the masticatory muscles. Overall, the complication rates post wisdom tooth surgery range from 2.6% to 30.9%.…”

“…These are infection, trauma, dental treatment, Temporomandibular Joint (TMJ) disorders, tumours and oral care, drugs, radiotherapy and chemotherapy, congenital problems and miscellaneous disorders. [1,2,3] The most common dental treatment leading to trismus is surgical removal of impacted wisdom tooth. [3] Also, it is well known that most of the times effect of trismus persist for five to seven days and at times more than a week after surgical removal of impacted wisdom tooth.…”

Untitled

“…A thorough review of the literature revealed a Spectrophotometric method for the quantification of Levosulpiride in bulk drug and formulation 7 . A UV method 8 for quantification in dissolution samples, HPTLC, and validated HPLC methods were reported for the simultaneous quantification of Levosulpiride with rabeprazole sodium [9][10][11][12][13] . Validated HPTLC methods were reported for the simultaneous quantification of Levosulpiride and esomeprazole in capsule dosage forms 14,15 .…”