Triptycene Derivatives as Medicinal Agents

Effect of Uridine Diphospho‐N‐acetylglucosamine and Sodium Salicylate on L‐Glutamine‐D‐Fructose-6-phosphaAtme inotransferase Activity from Rat Gastric Mucosa

“…Based on the consideration of the chemical structures of the two compounds, one can conceive of salicylate binding to the same site occupied by the pyrimidine ring of uridine. Other uridine diphospho sugars such as uridine diphospho galactose and glucose have been reported to inhibit the enzyme at concentrations that of uridine-5'-diphospho-N-acetylglucosamine (13). Kornfeld (13) was able partially to desensitize the enzyme to inhibition by uridine-5'-diphospho-N-acetylglucosamine, suggesting that the inhibitor site was distinct from the active site.…”

“…In addition, several reports indicated that hexosamine biosynthesis was subjected to feedback regulation by uridine-5'-diphospho-N-acetylglucosamine (13)(14)(15)(16). This feedback inhibition is on the initial enzyme of the pathway, catalyzing the apparent irreversible formation of glucosamine.…”

From gas separation to ion transport in the cavity of hyperbranched polyamides based on triptycene aimed for electrochromic and memory devices

“…Considering the open cavities in the 3D rigid structure of triptycene which could form particular channels that allow molecules of a certain size to enter and exit freely without cubical dilatation, triptycene was investigated extensively as a gas separation film. Owing to the special structure and facile functionalization of triptycene, it has attracted great interest in electro-optical fields 23–25 and has shown excellent phosphorescence (PL) and reversible redox properties which have been used in organic light-emitting diodes (OLEDs) and organic photovoltaic devices (OPVs). 26–32 However, to the best of our knowledge, Liou has introduced triptycene into the backbone of polymers by means of a third monomer, 33 but the exploration of the application of triptycene in the field of EC has not been performed extensively.…”

Spiro-fused bicyclo[3,2,2] octatriene-cored triptycene: synthesis, molecular packing, and functional aggregates

“…Subsequently, Witting et al synthesized triptycene via a onestep reaction using anthracene and phenylacetylene, which improved the synthetic yield to ~28% [41]. Alternatively, Walborsky et al [42] reacted anthraquinone with a Grignard reagent to generate anthranol derivatives, which were subjected to acid-catalyzed ring closure to form bridgeheadfunctionalized triptycenes. Furthermore, using the appropriate anthracenol derivatives, this dehydration-cyclization provided a novel bicyclo [3,2,2]octatriene, namely, homotriptycene (Figure 1, middle), which contains a new -CH 2group on the bridged ring of the classic triptycene [43][44][45][46][47][48][49].…”