Abstract:Pancreatic cancer is the fourth most common cause of cancer death worldwide with limited therapeutic potential and low survival rate. A natural agent; triptolide (diterpenoid triepoxide), induce cell viability loss, growth inhibition and apoptotic cell death in various cancer cells such as breast, prostate and pancreatic cancer. Metformin, a common therapeutic agent for type II Diabetes mellitus, has been shown to induce apoptotic cell death in pancreatic cancer via modulating various pathways such as PI3K/Akt… Show more
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