Triptolide inhibits CC chemokines expressed in rat adjuvant-induced arthritis

Wang, Yifan; Wei, Dengming; Lai, Zhao-Rong; Le, Yanping

doi:10.1016/j.intimp.2006.07.029

Cited by 22 publications

(16 citation statements)

References 34 publications

(42 reference statements)

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“…Lu et al (13) reported that TL may restrain the infiltration of immune cells into corneal fibroblast tissue in virtue of the suppression of IL-6, intercellular adhesion molecule 1 and chemokines induced by lipopolysaccharide. Wang et al (14) demonstrated that arthritic ankle thickness decreased after TL treatment in a rat model of adjuvant-induced arthritis (AA). In synovial tissue samples from rats with AA, the expression of monocyte chemoattractant protein (MCP)-1 and macrophage inflammatory protein (MIP)-1α was upregulated compared with that in normal control rats.…”

Section: Discussionmentioning

confidence: 99%

“…TL is known as a drug with marked pharmacological activities, including anti-inflammatory and immunomodulatory properties as well as improvement of the microcirculation; it inhibits the proliferation of various types of cancer cell and enhances tumor sensitivity to chemotherapy (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27). In the present study, the expression patterns of IL-6 in a mouse model of UC model were assessed, as well as association between the anti-colitis effects of TL and IL-6 levels.…”

Section: Introductionmentioning

confidence: 99%

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Interleukin 6 inhibition by triptolide prevents inflammation in a mouse model of ulcerative colitis

Zhang

Chen

2017

Experimental and Therapeutic Medicine

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Abstract. The present study aimed to assess interleukin (IL)-6 expression in a murine model of ulcerative colitis (UC) induced by dextran sulfate sodium (DSS) and its potential association with the anti-colitis effects of triptolide (TL). Serum IL-6 levels were measured by ELISA. IL-6 gene expression levels in colonic mucosa specimens were assessed by reverse-transcription quantitative PCR and protein expression was evaluated by western blot analysis and immunohistochemistry. The expression of IL-6 was weak in mucosa specimens from normal control animals and upregulated in DSS-induced mice. In model mice treated with TL (0.4 and 0.6 mg/kg), dexamethasone or mesalazine, IL-6 expression was significantly reduced compared with that in model mice treated with normal saline or propylene glycol (P<0.05), while TL at 0.2 mg/kg did not elicit any significant inhibitory effect. There was no significant difference among TL (0.4 mg/kg and 0.6 mg/kg), mesalazine and dexamethasone treatments (P>0.05) in terms of IL-6 expression or histological score. The results of the present study indicated that IL-6 was overexpressed in a mouse model of UC and was involved in disease progression. In addition, TL exerted therapeutic effects in UC through inhibition of IL-6 expression.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Interleukin 6 inhibition by triptolide prevents inflammation in a mouse model of ulcerative colitis

Zhang

Chen

2017

Experimental and Therapeutic Medicine

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“…In collagen-induced arthritis (CIA) model mice, triptolide significantly reduced the inflammatory responses and cartilage damage in the joint tissues by interfering with CIA-induced expression of MMP-13 and -3 and by augmenting TIMP-1 and -2 expressions in the joints [18]. Triptolide also inhibited CCR5 expression in synovial tissue [21] and CC chemokines expression in rat adjuvant-induced arthritis [22]. Triptolide combined with glycyrrhizin reduced the arthritic index of CIA rats and decreased the level of anti-CII IgG and TNF-α in serum [23].…”

Section: Triptolide and Autoimmune Diseasesmentioning

confidence: 99%

Triptolide and its expanding multiple pharmacological functions

Liu

2011

International Immunopharmacology

298

197

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“…Triptolide signiWcantly inhibited expression of MCP-1, MIP-1 , and RANTES at both mRNA and protein levels in adjuvant-induced arthritis rats [56]. Furthermore, triptolide displayed an immunosuppressive eVect on CIA by downregulating collagen II-speciWc Th17 cells, which was conWrmed in vitro that triptolide signiWcantly inhibited the transcription of IL-17 mRNA and the generation of Th17 cells from murine splenocytes and puriWed CD4(+) T cells by inhibiting IL-6-induced phosphorylation of STAT3, a key signaling molecule involved in the development of Th17 cells [57].…”

Section: Evects On Arthritis Modelsmentioning

confidence: 95%

A Chinese herb Tripterygium wilfordii Hook F in the treatment of rheumatoid arthritis: mechanism, efficacy, and safety

2011

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Tripterygium wilfordii Hook F (TwHF) is a Chinese herb with immunosuppressive effects and an established history of use in the treatment of rheumatoid arthritis (RA). Numerous preclinical studies have demonstrated that the extracts from the root of TwHF inhibit the expression of proinflammatory cytokines, proinflammatory mediators, adhesion molecules, and matrix metalloproteinases by macrophages, lymphocytes, synovial fibroblasts, and chondrocytes. TwHF also induces apoptosis in lymphocytes and synovial fibroblasts and inhibits their proliferation. Except numerous uncontrolled clinical trials, there are some prospective, double-blind, randomized, and placebo/sulfasalazine-controlled trials, also demonstrating greater improvement in RA disease activity by TwHF extract than placebo/sulfasalazine. Radiographic progression in RA may also be retarded by TwHF. Therefore, the immunosuppressive, cartilage protective, and anti-inflammatory effects of TwHF extracts are well demonstrated, and TwHF extract is an alternative disease modifying anti-rheumatic drug (DMARD) for the patients with RA refractory to conventional therapy.

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Triptolide inhibits CC chemokines expressed in rat adjuvant-induced arthritis

Cited by 22 publications

References 34 publications

Interleukin 6 inhibition by triptolide prevents inflammation in a mouse model of ulcerative colitis

Interleukin 6 inhibition by triptolide prevents inflammation in a mouse model of ulcerative colitis

Triptolide and its expanding multiple pharmacological functions

A Chinese herb Tripterygium wilfordii Hook F in the treatment of rheumatoid arthritis: mechanism, efficacy, and safety

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