Triptolide decreases podocytes permeability by regulating TET2-mediated hydroxymethylation of ZO-1
Yue-Wen Tang,
Meng-Ya Jiang,
Jia-Wei Cao
et al.
Abstract:Podocyte injury or dysfunction can lead to proteinuria and glomerulosclerosis. Zonula occludens 1 (ZO-1) is a tight junction protein which connects slit diaphragm (SD) proteins to the actin cytoskeleton. Previous studies have shown that the expression of ZO-1 is decreased in chronic kidney disease (CKD). Thus, elucidation of the regulation mechanism of ZO-1 has considerable clinical importance. Triptolide (TP) has been reported to exert a strong antiproteinuric effect by inhibiting podocyte epithelial mesenchy… Show more
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