Triptans and ergot alkaloids in the acute treatment of migraine: similarities and differences

Tfelt‐Hansen, Peer

doi:10.1586/14737175.2013.832851

Cited by 8 publications

(6 citation statements)

References 18 publications

(43 reference statements)

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“…Amides and peptides containing lysergic acid have contaminated grain and forage crops resulting in human and animal toxicoses (1)(2)(3)(4). Additionally, derivatives of lysergic acid are used to synthesize a range of pharmaceuticals used to treat dementia, migraines, Parkinson's disease, and hyperprolactinemia (5)(6)(7)(8). Lysergic acidderived ergot alkaloids are produced by representatives of several genera in the fungal family Clavicipitaceae, including Claviceps spp., Epichloë spp., Balansia spp., and Periglandula spp.…”

mentioning

confidence: 99%

Several Metarhizium Species Produce Ergot Alkaloids in a Condition-Specific Manner

Leadmon

Sampson

Maust

et al. 2020

Appl Environ Microbiol

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ABSTRACT Genomic sequence data indicate that certain fungi in the genus Metarhizium have the capacity to produce lysergic acid-derived ergot alkaloids, but accumulation of ergot alkaloids in these fungi has not been demonstrated previously. We assayed several Metarhizium species grown under different conditions for accumulation of ergot alkaloids. Isolates of M. brunneum and M. anisopliae accumulated the lysergic acid amides lysergic acid α-hydroxyethyl amide, ergine, and ergonovine on sucrose-yeast extract agar but not on two other tested media. Isolates of six other Metarhizium species did not accumulate ergot alkaloids on sucrose-yeast extract agar. Conidia of M. brunneum lacked detectable ergot alkaloids, and mycelia of this fungus secreted over 80% of their ergot alkaloid yield into the culture medium. Isolates of M. brunneum, M. flavoviride, M. robertsii, M. acridum, and M. anisopliae produced high concentrations of ergot alkaloids in infected larvae of the model insect Galleria mellonella, but larvae infected with M. pingshaense, M. album, M. majus, and M. guizhouense lacked detectable ergot alkaloids. Alkaloid concentrations were significantly higher when insects were alive (as opposed to killed by freezing or gas) at the time of inoculation with M. brunneum. Roots of corn and beans were inoculated with M. brunneum or M. flavoviride and global metabolomic analyses indicated that the inoculated roots were colonized, though no ergot alkaloids were detected. The data demonstrate that several Metarhizium species produce ergot alkaloids of the lysergic acid amide class and that production of ergot alkaloids is tightly regulated and associated with insect colonization. IMPORTANCE Our discovery of ergot alkaloids in fungi of the genus Metarhizium has agricultural and pharmaceutical implications. Ergot alkaloids produced by other fungi in the family Clavicipitaceae accumulate in forage grasses or grain crops; in this context they are considered toxins, though their presence also may deter or kill insect pests. Our data report ergot alkaloids in Metarhizium species and indicate a close association of ergot alkaloid accumulation with insect colonization. The lack of accumulation of alkaloids in spores of the fungi and in plants colonized by the fungi affirms the safety of using Metarhizium species as biocontrol agents. Ergot alkaloids produced by other fungi have been exploited to produce powerful pharmaceuticals. The class of ergot alkaloids discovered in Metarhizium species (lysergic acid amides) and their secretion into the growth medium make Metarhizium species a potential platform for future studies on ergot alkaloid synthesis and modification.

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mentioning

confidence: 99%

Several Metarhizium Species Produce Ergot Alkaloids in a Condition-Specific Manner

Leadmon

Sampson

Maust

et al. 2020

Appl Environ Microbiol

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“…These mechanisms are mediated by 5-HT1B/1D receptors. The high affinity of the triptans for 5-HT1B/1D receptors and their favorable pharmacologic properties contribute to the beneficial effects of these drugs, including rapid onset of action, effective relief of headache and associated symptoms, and low incidence of adverse effects [43].…”

Section: Triptansmentioning

confidence: 99%

“…They constrict the arteries and veins by direct stimulation of cerebral vascular smooth muscle. a. Ergotamine and b. Dihydroergotamine: It is an α1-adrenoceptor antagonist [43].…”

Section: Mechanism Of Actionmentioning

confidence: 99%

A Review on Classification, Pathophysiology, Diagnosis, and Pharmacotherapy of Headache

Mogilicherla¹,

Mamindla²,

Enumula

2020

Innovare J Med Sci

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Headache disorders, characterized by recurrent headache, are among the most common disorders of the nervous system. Headache disorder is classified mainly into two major types, primary headache and secondary headache by the International Classification of Headache Disorders. Most types of headache are diagnosed by the clinical history and from headache classification committee of the International Headache Society (IHS). A number of intrinsic or extrinsic factors can trigger headache attack which release neurotransmitters and activate trigeminal vascular system. The grading of headache intensity is done by headache severity scale of IHS. Headache management includes pharmacological and non-pharmacological treatment.

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“…Ergots are moderately effective and preferred for frequent attacks of migraine. Triptans are considered as the most effective group of medication; however, they are avoided among patients with underlying cardiovascular diseases [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

“…Basil (Ocimum basilicum L.; Lamiaceae family) is among the most important medicinal plants and has many useful compounds including linalool, cineole, estragole, gamma-terpinene, geraniol, menthol, eugenol, and many others [6,[25][26][27]. These ingredients provide effects like anti-inflammatory, anxiolytic, tunic, diuretic, digestive enhancer, anti-flatulence, anti-dandruff, anticoagulant, cough suppressant, antiseptic, anti-diabetes, and immune-modulatory effects [28,29].…”

Section: Introductionmentioning

confidence: 99%

The Efficacy of Topical Basil Essential Oil on Relieving Migraine Headaches: A Randomized Triple-Blind Study

et al. 2020

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Objective: Complementary therapies have been increasingly used for the prevention and treatment of migraine so that there is a need for studies in this setting. This study sought to determine the effects of basil essential oil on the severity and frequency of migraine attack headaches. Methods: A triple-blind clinical trial study was performed on 144 patients diagnosed with migraine. Patients were randomly allocated by a stratified method to four groups of 36 titled basil essential oil 2, 4, 6%, and placebo groups. Medications were used topically every 8 h for 3 successive months. In addition, each individual received 325 mg of acetaminophen every 12 h. The severity and frequency of migraine attacks were measured prior to the study, at weeks 2, 4, 8, and 12. The visual analog scale was used to measure pain intensity. The marginal model and generalized estimation equations were used to compare changes in the intensity and frequency of pain over time. Results: The interaction of the dose and time factors was significant on both pain intensity (p < 0.001) and frequency of attack (p < 0.001). The odds ratio of higher pain intensity and rate ratio of higher frequency of attack in the intervention groups compared to the placebo group were decreased over the study time. Conclusion: Time lapse and higher doses of basil essential oil would reduce both the intensity and frequency of migraine attacks.

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Triptans and ergot alkaloids in the acute treatment of migraine: similarities and differences

Cited by 8 publications

References 18 publications

Several Metarhizium Species Produce Ergot Alkaloids in a Condition-Specific Manner

Several Metarhizium Species Produce Ergot Alkaloids in a Condition-Specific Manner

A Review on Classification, Pathophysiology, Diagnosis, and Pharmacotherapy of Headache

The Efficacy of Topical Basil Essential Oil on Relieving Migraine Headaches: A Randomized Triple-Blind Study

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