Triple therapy with clarithromycin, omeprazole, and amoxicillin for eradication of Helicobacter pylori in duodenal ulcer patients in Asia and Africa

Abstract

INTRODUCTIONHelicobacter pylori infection is recognized as a causative factor for development of duodenal ulcers. H. pylori eradication results in ulcer healing, prevention of ulcer recurrence, and decreased overall use of health care SUMMARY Background: Studies assessing the ef®cacy of triple therapy containing clarithromycin and amoxicillin for the eradication of Helicobacter pylori infection and healing of duodenal ulcers in Asian and African countries are limited. Aim: To determine the ef®cacy and safety of 1-week triple therapy with omeprazole, amoxicillin and clarithromycin for eradicating H. pylori infection in patients with active duodenal ulcer living in Asian and African regions. Methods:This was an open-label, multicentre study in 11 centres in Asia and Africa. Patients with endoscopyproven duodenal ulcer and who were H. pylori-positive were treated with clarithromycin 500 mg, omeprazole 20 mg, and amoxicillin 1000 mg, all given twice daily

Furazolidone, Co-amoxiclav, Colloidal Bismuth Subcitrate, and Esomeprazole for Patients Who Failed to Eradicate Helicobacter pylori with Triple Therapy

“…We have previously reported high prevalence of clarithromycin resistance among our patients with H. pylori infection [19]. In a previous multicenter study done in patients with documented active duodenal ulcer, 1-week triple therapy with PPI, amoxicillin, and clarithromycin gave an eradication rate of 62% with ITT analysis in a group of patients recruited from Pakistan [20]. In our study, we had a 32% failure rate of triple therapy to eradicate H. pylori infection despite giving it for 2 weeks.…”

Current Status of H. pylori Infection Treatment 2017

“…But it proved that non-metronidazole regimens are currently regarded and more suitable treatment of H. pylori infection in Asia and Africa. It is reported that eradication rate is 90% for clarithromycin, a PPI and amoxicillin for 7-10 days (Wong et al, 2000;Dolapcioglu et al, 2014). In the last decade, 7-10 days triple therapies have unacceptably low cure rates, but higher triple therapy has increased the cure rate as compared to 7-10 day regimen.…”

“…The annual report that H. pylori re-infection rate is greater in Asia (4.3-13%) than the west (0.5-2.5) (Ramesh et al, 2017). In Asia, studies shown that the prevalence of H. pylori infection rates are slightly higher more population country (58% in China, 60% in South Korea, 75% in Vietnam, 79% in India, and 92% in Bangladesh) than lower population (31% in Singapore, 36% in Malaysia, 39% in Japan, 55% in Taiwan, 57% in Thailand) (Yang et al, 2014). H. pylori infection can lead to a different upper gastrointestinal disorder such as gastric inflammation (gastritis), heartburn, gastroesophageal reflux disease, gastric duodenal ulcer disease, gastric cancer and mucosa-associated lymphoid tissue (MALT).…”

Trithérapie par oméprazole, amoxicilline et clarithromycine dans la maladie ulcéreuse duodénale associée à Helicobacter pylori au Sénégal

“…Cependant, chez les malades dont l'ancienneté de la MUD était supérieure à cinq ans, un taux d'échec supérieur à 33,3 % était observé. [8,10,11]. Les principaux facteurs pouvant influencer l'efficacité des traitements éradicateurs sont l'observance du traitement et les résistances bactériennes [6,11].…”

“…En effet, même si les schémas de sept jours restent recommandés en Asie, il est maintenant reconnu en Europe et aux États-Unis que les schémas de 14 jours donnent de meilleurs résultats [1][2][3]13]. Le taux de cicatrisation obtenu dans cette étude, 86,4 % en per protocole, est analogue aux taux observés dans les études asiatiques et africaines [9,10]. L'efficacité du traitement éradicateur sur les symptômes était de 81 % en per protocole, seuls 19 % des malades évalués présen-taient une symptomatologie douloureuse après l'éradication.…”