Triple therapy (aspirin, clopidogrel and oral anticoagulant) after percutaneous coronary intervention: another call for personalized medicine

Tanrikulu, Azra Meryem; Ağırbaşlı, Mehmet

doi:10.5152/akd.2013.147

Cited by 2 publications

(1 citation statement)

References 57 publications

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“…Integrated multi-omics studies are becoming increasingly important in the context of personalized medicine, where treatment decisions are based on patients’ omics, demographic, clinical and environmental data [7,8,9,10,11]. The recently released integrative personal omics profile (iPOP) study is a pioneering work in the field of personalized omics profiling.…”

Section: Introductionmentioning

confidence: 99%

Integrative Analysis of Longitudinal Metabolomics Data from a Personal Multi-Omics Profile

et al. 2013

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The integrative personal omics profile (iPOP) is a pioneering study that combines genomics, transcriptomics, proteomics, metabolomics and autoantibody profiles from a single individual over a 14-month period. The observation period includes two episodes of viral infection: a human rhinovirus and a respiratory syncytial virus. The profile studies give an informative snapshot into the biological functioning of an organism. We hypothesize that pathway expression levels are associated with disease status. To test this hypothesis, we use biological pathways to integrate metabolomics and proteomics iPOP data. The approach computes the pathways’ differential expression levels at each time point, while taking into account the pathway structure and the longitudinal design. The resulting pathway levels show strong association with the disease status. Further, we identify temporal patterns in metabolite expression levels. The changes in metabolite expression levels also appear to be consistent with the disease status. The results of the integrative analysis suggest that changes in biological pathways may be used to predict and monitor the disease. The iPOP experimental design, data acquisition and analysis issues are discussed within the broader context of personal profiling.

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