Triple Test Approach to Inadequate Fine Needle Aspiration Biopsies of Palpable Breast Lesions

Salami, Naghmeh; Hirschowitz, Sharon L.; Nieberg, Roberta K.; Apple, Sophia K.

doi:10.1159/000331078

Cited by 12 publications

(4 citation statements)

References 8 publications

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“…Misdirected aspirates or misinterpretation of the cytology are possible reasons for the reporting of benign cytology among cancers. Previous reports indicate that a misdirected (nonrepresentative) biopsy is a far more frequent cause for this outcome 14…”

Section: Discussionmentioning

confidence: 96%

Combined use of imaging and cytologic grading schemes for screen-detected breast abnormalities improves overall diagnostic accuracy

Farshid

Downey

2005

Cancer

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In brachiating gibbons, it is thought that there is little movement in the hindlimb joints and that lateral body movement is quite limited. These hypotheses are based on naked‐eye observations, and no quantitative motion analyses of the hindlimbs have been reported. This study quantitatively describes the three‐dimensional movements of the lower trunk and distal thigh during continuous‐contact brachiation in a white‐handed gibbon (Hylobates lar) to evaluate the roles of the trunk and hindlimb. The results revealed that the lower trunk moved both laterally and vertically. The lateral movement of the lower trunk resulted from the lateral inclination of the trunk by gravity. The vertical movement of the trunk was converted into forward velocity, indicating an exchange between potential and kinetic energy. We also observed flexion and extension of the hip, although the excursion was within a small range. In addition, the lateral movement of the hindlimb in thedirection opposite to that of trunk movement helped to reduce the lateral sway of the body. These results suggest that during continuous‐contact brachiation a gibbon uses hip flexion and extension motions to increase the kinetic energy in the swing. In addition, fine motions of the hip may restrict the lateral sway of the center of body mass. Am J Phys Anthropol 142:650–654, 2010. © 2010 Wiley‐Liss, Inc.

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Section: Discussionmentioning

confidence: 96%

Combined use of imaging and cytologic grading schemes for screen-detected breast abnormalities improves overall diagnostic accuracy

Farshid

Downey

2005

Cancer

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“…However, in as many as 40% of cases, the cytological findings are not concordant. 10 The sensitivity of FNAC for carcinomas varies from 35% to 95%, and specificity varies from 48% to 100% in the literature. 11 12 13 14 15 False positivity of the procedure was low, and this rate was reported as <1% in the literature.…”

Section: Discussionmentioning

confidence: 99%

The role of fine needle aspiration cytology and core biopsy in the diagnosis of palpable breast masses

et al. 2016

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Background:The modern approach to palpable breast masses is to get cytopathologic diagnosis before definitive surgery. We aimed to compare fine needle aspiration cytology (FNAC) with core biopsy in histopathologic diagnosis of palpable breast masses.Materials and Methods:Data were collected on 123 women who have suspicious palpable breast masses from 2007 to 2010.Results:Of the 123 patients, core biopsies were performed on 64 patients (Group 1) and FNAC on 59 patients (Group 2). Malignancy was confirmed in 25 out of 32 clinically suspicious patients in Group 1 (78.1%), and 20 out of 21 participants in Group 2 (95.2%). Among the clinically suspicious patients, 81.8% of 33 patients in Group 1, and 90.3% of 31 patients in Group 2 were identified malignancy. Sensitivity was 100% for core biopsy and 95% for FNAC. Specificity was 100% in both procedures. False negativity rate in FNAC were 5%.Conclusion:Sensitivity and specificity showed that in the case of true histopathologic classification, core biopsy is superior to FNAC. Nevertheless, FNAC's role as a fast, simple and cheap diagnosis cannot be ignored. It is an effective diagnostic tool in most patients, in comparison to the correct and specific typing of core biopsies in benign lesions which protect patients from the open biopsy.

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“…In their study on nonpalpable breast lesions, Ibrahim et al [62] demonstrated a high inadequacy rate for FNAB (58.7%). In another study on nonpalpable breast lesions, FNAB was inadequate in 22% of the cases [63]. …”

Section: Advantages Of the Combined Approachmentioning

confidence: 99%

Fine-Needle Aspiration Followed by Core-Needle Biopsy in the Same Setting: Modifying Our Approach

Joudeh¹,

Shareef²,

Al‐Abbadi³

2016

Acta Cytologica

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Fine-needle aspiration biopsy (FNAB) is a well-established initial diagnostic tool. However, in some instances limitations and shortcomings arise, making it insufficient for determining a specific diagnosis. Consequently, patients have to undergo another diagnostic procedure. The second procedure is either repeat FNAB, core-needle or open biopsy, and can be inconvenient and costly. In some centers, the FNAB is immediately followed by core-needle biopsy (CNB) in the same setting after assuring adequacy on the initial FNAB utilizing rapid on-site specimen evaluation (ROSE). It is argued that implementing such an approach will eventually have additional critical advantages that include the following: (a) it is more convenient to patients to have both procedures in one visit, (b) the tissue procured by both procedures will be more adequate, enabling cytopathologists to reach an accurate diagnosis, and (c) it is ultimately a cost-effective approach if we take into consideration the avoidance of a potential second more invasive diagnostic procedure. Since we are living in an era of patient-centered medicine coupled with cost-cutting strategies, we present here a brief review of the topic with analysis of this alternative approach, review of the pertinent literature and shed light on a few scenarios that justify this approach.

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Triple Test Approach to Inadequate Fine Needle Aspiration Biopsies of Palpable Breast Lesions

Cited by 12 publications

References 8 publications

Combined use of imaging and cytologic grading schemes for screen-detected breast abnormalities improves overall diagnostic accuracy

Combined use of imaging and cytologic grading schemes for screen-detected breast abnormalities improves overall diagnostic accuracy

The role of fine needle aspiration cytology and core biopsy in the diagnosis of palpable breast masses

Fine-Needle Aspiration Followed by Core-Needle Biopsy in the Same Setting: Modifying Our Approach

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