Triple signal amplification strategy based on size and shape transformation of ultrasmall sub-10 nm gold nanoparticles tag towards sensitivity improvement of electrochemical immunosensors

Duangkaew, Pattasuda; Wutikhun, Tuksadon; Laocharoensuk, Rawiwan

doi:10.1016/j.snb.2016.08.037

Cited by 20 publications

(7 citation statements)

References 42 publications

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“…In this method, the size of AuNPs was increased by forming an Au shell on the surface of the small AuNP tags, and then the spiky AuNPs were grown on the surface of Au shell, with the benefit of enhancing the catalysis of silver. Compared to the traditional GLSS process, this triple signal amplification strategy magnified the electrical signal by 260 times (Figure 8) [135].…”

Section: Electrochemical Biosensorsmentioning

confidence: 99%

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Applications of Gold Nanoparticles in Non-Optical Biosensors

et al. 2018

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Due to their unique properties, such as good biocompatibility, excellent conductivity, effective catalysis, high density, and high surface-to-volume ratio, gold nanoparticles (AuNPs) are widely used in the field of bioassay. Mainly, AuNPs used in optical biosensors have been described in some reviews. In this review, we highlight recent advances in AuNP-based non-optical bioassays, including piezoelectric biosensor, electrochemical biosensor, and inductively coupled plasma mass spectrometry (ICP-MS) bio-detection. Some representative examples are presented to illustrate the effect of AuNPs in non-optical bioassay and the mechanisms of AuNPs in improving detection performances are described. Finally, the review summarizes the future prospects of AuNPs in non-optical biosensors.

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Section: Electrochemical Biosensorsmentioning

confidence: 99%

“…Linear sweep voltametric analysis was performed to detect deposited silver. Reproduced with permission from [135]. Elsevier, 2017.…”

Section: Figurementioning

confidence: 99%

Applications of Gold Nanoparticles in Non-Optical Biosensors

et al. 2018

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“…The immunosensor exhibited a linear range from 0.1 pg mL −1 to 100 ng mL −1 with a LoD of 0.03 pg mL −1 . Also in 2017, Duangkaew et al [ 144 ] described spiky AuNPs for PSA detection. Such spiky AuNPs were used for silver deposition.…”

Section: Discussionmentioning

confidence: 99%

Recent Advances in Electrochemical Immunosensors

Piro

Reisberg

2017

Sensors

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Immunosensors have experienced a very significant growth in recent years, driven by the need for fast, sensitive, portable and easy-to-use devices to detect biomarkers for clinical diagnosis or to monitor organic pollutants in natural or industrial environments. Advances in the field of signal amplification using enzymatic reactions, nanomaterials such as carbon nanotubes, graphene and graphene derivatives, metallic nanoparticles (gold, silver, various oxides or metal complexes), or magnetic beads show how it is possible to improve collection, binding or transduction performances and reach the requirements for realistic clinical diagnostic or environmental control. This review presents these most recent advances; it focuses first on classical electrode substrates, then moves to carbon-based nanostructured ones including carbon nanotubes, graphene and other carbon materials, metal or metal-oxide nanoparticles, magnetic nanoparticles, dendrimers and, to finish, explore the use of ionic liquids. Analytical performances are systematically covered and compared, depending on the detection principle, but also from a chronological perspective, from 2012 to 2016 and early 2017.

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“…An enzymatic reaction leading to silver reduction is also an alternative approach to produce the deposition of AgNPs on the surface of AuNPs [115], which were quantified using SPEs by recording the silver stripping signal. Another work, also for the detection of AuNPs, was reported following a multistep amplification strategy [116]. Sub-10 nm AuNPs were enhanced acting as nucleation seeds for chemical deposition of a gold shell (using HAuCl 4 and ascorbic acid as reducing agent).…”

Section: Strategies For Electrochemical Detection Of Nanoparticlesmentioning

confidence: 99%

Electrochemical Detection and Characterization of Nanoparticles with Printed Devices

Martín‐Yerga

2019

Biosensors

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Innovative methods to achieve the user-friendly, quick, and highly sensitive detection of nanomaterials are urgently needed. Nanomaterials have increased importance in commercial products, and there are concerns about the potential risk that they entail for the environment. In addition, detection of nanomaterials can be a highly valuable tool in many applications, such as biosensing. Electrochemical methods using disposable, low-cost, printed electrodes provide excellent analytical performance for the detection of a wide set of nanomaterials. In this review, the foundations and latest advances of several electrochemical strategies for the detection of nanoparticles using cost-effective printed devices are introduced. These strategies will equip the experimentalist with an extensive toolbox for the detection of nanoparticles of different chemical nature and possible applications ranging from quality control to environmental analysis and biosensing.

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Triple signal amplification strategy based on size and shape transformation of ultrasmall sub-10 nm gold nanoparticles tag towards sensitivity improvement of electrochemical immunosensors

Cited by 20 publications

References 42 publications

Applications of Gold Nanoparticles in Non-Optical Biosensors

Applications of Gold Nanoparticles in Non-Optical Biosensors

Recent Advances in Electrochemical Immunosensors

Electrochemical Detection and Characterization of Nanoparticles with Printed Devices

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