Triple-Quantum-Filtered 23Na NMR Spectroscopy of Subcutaneously Implanted 9L Gliosarcoma in the Rat in the Presence of TmDOTP5−

Winter, Patrick M.; Bansal, Navin

doi:10.1006/jmre.2001.2390

Cited by 34 publications

(34 citation statements)

References 32 publications

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“…The SIRFLA sequence can also theoretically facilitate “full elimination” of the ECS signal contribution. In vivo TQF studies suggest a 40% residual contribution from the ECS (20).…”

Section: Discussionmentioning

confidence: 99%

In vivo sodium magnetic resonance imaging of the human brain using soft inversion recovery fluid attenuation

Stobbe

Beaulieu

2005

Magnetic Resonance in Med

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Sodium imaging with soft inversion recovery fluid attenuation, which may be advantageous for intracellular weighting, was demonstrated with cerebrospinal fluid (CSF) suppression in five healthy volunteers at 4.7 T. Long rectangular inversion pulses reduce the average power deposition in an inversion recovery sequence, allowing repetition time to be shortened and more averages acquired for a given scan length. Longer pulses also significantly reduce the "depth" of M z inversion in environments with rapid T 1 and T 2 relaxation (i.e., brain relative to CSF). Phantom experiments and simulation show a marked SNR increase when using a 10-ms, rather than a 1-ms, rectangular inversion pulse. Images were acquired in 11.1 min with a voxel size of 0.25 cm 3 and the SNR in CSF, which is typically ϳ3 times larger than in brain, was reduced to 23% of that in the brain tissue, which had an average SNR of 17. Magn Reson Med 54: 1305-1310, 2005.

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“…The SIRFLA sequence can also theoretically facilitate “full elimination” of the ECS signal contribution. In vivo TQF studies suggest a 40% residual contribution from the ECS (20).…”

Section: Discussionmentioning

confidence: 99%

In vivo sodium magnetic resonance imaging of the human brain using soft inversion recovery fluid attenuation

Stobbe

Beaulieu

2005

Magnetic Resonance in Med

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“…In the case of sodium, a very important ion in cell physiology, these techniques have been further explored for the separation of the NMR signal between the intra-and extra-cellular compartments in the context of animal models of disease [1]. Triple quantum sodium NMR techniques, in particular, have been used for the observation of sodium ion shifts during ischemia [2] and for the identification of neoplastic changes in human and/or animal tissues [1,3].…”

Section: Introductionmentioning

confidence: 99%

Triple-quantum-filtered imaging of sodium in presence of B0 inhomogeneities

Tanase

Boada

2005

Journal of Magnetic Resonance

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“…Controlled RF HT produced a gradual increase in both SQ and TQF 23 Na SA. These changes in SQ 23 Na spectra reflects changes in tumour Na þ t and those in TQF 23 Na spectra reflects changes in tumour Na þ i [20]. The HT treatment produced a 30-40% ( p 0.05) irreversible increase in TQF 23 Na SA compared to a reversible 12% increase ( p 0.05) in SQ 23 Na SA.…”

Section: In-magnet Controlled Ht Techniquementioning

confidence: 86%

“…Previous studies demonstrate that although a significant Na þ e signal contributes to the TQF signal from 9L-gliosarcoma and other tissue, this contribution is small compared to Na þ i signal. In addition TQF Na þ e signal is relatively insensitive to changes in Na þ e content [20]. Thus, the TQF 23 Na signal can be used to monitor changes inNa þ i .…”

Section: Discussionmentioning

confidence: 99%

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Controlled radio-frequency hyperthermia using an MR scanner and simultaneous monitoring of temperature and therapy response by¹H,²³Na and³¹P magnetic resonance spectroscopy in subcutaneously implanted 9L-gliosarcoma

James

Gao

Soon

et al. 2010

International Journal of Hyperthermia

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A magnetic resonance (MR) technique is developed to produce controlled radio-frequency (RF) hyperthermia (HT) in subcutaneously-implanted 9L-gliosarcoma in Fisher rats using an MR scanner and its components; the scanner is also simultaneously used to monitor the tumour temperature and the metabolic response of the tumour to the therapy. The method uses the (1)H chemical shift of thulium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra-acetic acid (TmDOTA(-)) to monitor temperature. The desired HT temperature is achieved and maintained using a feedback loop mechanism that uses a proportional-integral-derivative controller. The RF HT technique was able to heat the tumour from 33 degrees to 45 degrees C in approximately 10 min and was able to maintain the tumour temperature within +/-0.2 degrees C of the target temperature (45 degrees C). Simultaneous monitoring of the metabolic changes with RF HT showed increases in total tissue and intracellular Na(+) as measured by single-quantum and triple-quantum filtered (23)Na MR spectroscopy (MRS), respectively, and decreases in intra- and extracellular pH and cellular bioenergetics as measured by (31)P MRS. Monitoring of metabolic response in addition to the tumour temperature measurements may serve as a more reliable and early indicator of therapy response. In addition, such measurements during HT treatment will enhance our understanding of the tumour response mechanisms during HT, which may prove valuable in designing methods to improve therapeutic efficiency.

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Triple-Quantum-Filtered 23Na NMR Spectroscopy of Subcutaneously Implanted 9L Gliosarcoma in the Rat in the Presence of TmDOTP5−

Cited by 34 publications

References 32 publications

In vivo sodium magnetic resonance imaging of the human brain using soft inversion recovery fluid attenuation

In vivo sodium magnetic resonance imaging of the human brain using soft inversion recovery fluid attenuation

Triple-quantum-filtered imaging of sodium in presence of B0 inhomogeneities

Controlled radio-frequency hyperthermia using an MR scanner and simultaneous monitoring of temperature and therapy response by¹H,²³Na and³¹P magnetic resonance spectroscopy in subcutaneously implanted 9L-gliosarcoma

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Triple-Quantum-Filtered 23Na NMR Spectroscopy of Subcutaneously Implanted 9L Gliosarcoma in the Rat in the Presence of TmDOTP5−

Cited by 34 publications

References 32 publications

In vivo sodium magnetic resonance imaging of the human brain using soft inversion recovery fluid attenuation

In vivo sodium magnetic resonance imaging of the human brain using soft inversion recovery fluid attenuation

Triple-quantum-filtered imaging of sodium in presence of B0 inhomogeneities

Controlled radio-frequency hyperthermia using an MR scanner and simultaneous monitoring of temperature and therapy response by1H,23Na and31P magnetic resonance spectroscopy in subcutaneously implanted 9L-gliosarcoma

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Controlled radio-frequency hyperthermia using an MR scanner and simultaneous monitoring of temperature and therapy response by¹H,²³Na and³¹P magnetic resonance spectroscopy in subcutaneously implanted 9L-gliosarcoma