Triple negative breast carcinoma is a prognostic factor in Taiwanese women

Lin, Chih‐Hsueh; Chien, Su Yu; Chen, Chien-Jen; Kuo, Shou Jen; Chang, Ta-Yuan; Chen, Dar Ren

doi:10.1186/1471-2407-9-192

Cited by 34 publications

(42 citation statements)

References 23 publications

(67 reference statements)

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“…31 The prevalence of TNBC varies according to ethnicity and has been reported as high as 82% in Ghana, 32 39% in Saudi Arabia, 33 19.3% in China, 32 and 15.9% in Taiwan. 34 The distribution according to clinical disease stage in our study population (localized disease, 44.3%; regional disease, 44%; and distant disease, 11.7%) was similar to that reported in African-American patients (51%, 37%, and 10%, respectively) 1 and Hispanic-American patients (54%, 37%, and 7%, respectively) with breast cancer. 35 All of these distributions differ significantly from those reported in white patients with breast cancer (63%, 29%, and 5%, respectively).…”

Section: Discussionsupporting

confidence: 51%

Triple-negative breast cancer in Hispanic patients

Lara‐Medina

Pérez-Sánchez²,

Saavedra-Pérez

et al. 2011

Cancer

161

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Section: Discussionsupporting

confidence: 51%

Triple-negative breast cancer in Hispanic patients

Lara‐Medina

Pérez-Sánchez²,

Saavedra-Pérez

et al. 2011

Cancer

161

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“…A literature review revealed higher rates of recurrence and reduced breast cancer-specific survival with TNBC (29-32) but no significant difference in terms of stage or lymph node positivity with other breast cancers at diagnosis (31). Regarding the rate of distant metastases at diagnosis, the literature data showed either higher or lower rates with TNBC than with breast cancers that were not TNBC (10,(33)(34)(35), but no study reported statistically significant lower rates. Further studies are needed to confirm the statistical significance of this relationship.…”

Section: Discussionmentioning

confidence: 99%

Rate of Distant Metastases on ¹⁸F-FDG PET/CT at Initial Staging of Breast Cancer: Comparison of Women Younger and Older Than 40 Years

et al. 2016

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Women who have breast cancer and are younger than 40 y have a poorer outcome than older women. A higher rate of undetected metastases at the time of diagnosis in younger women has been proposed to account for this difference. Our main objective was to test this hypothesis by comparing the distant metastasis rate (DMR) on initial 18 F-FDG PET/CT in a group of breast cancer patients younger than 40 y (,40 y group) with that in a group of breast cancer patients older than 40 y ($40 y group). An assessment of associations between distant metastases and tumor characteristics was a second objective of the present study. Methods: A retrospective single-institution study was performed on women who had breast cancer and no prior malignancy, who were asymptomatic for metastatic lesions on initial clinical examination, and who had initial 18 F-FDG PET/CT within 3 mo after pathologic breast cancer diagnosis and before initial treatment. On the basis of these criteria, data for 2 groups of women differing only in age (,40 y and $40 y) were extracted from the hospital information system of Curie Institute-Paris. 18 F-FDG PET/CT examinations were reviewed, and the DMR was recorded for each clinical stage subgroup (stages I-III). Results: For each group (,40 y and $40 y), 107 patients were included, with the same number of patients in each clinical stage subgroup (12 stage I patients, 32 stage IIA patients, 30 stage IIB patients, and 33 stage III patients). The ages of the patients (mean 6 SD) were 34.5 6 4.0 y (,40 y group) and 56.0 6 10.7 y ($40 y group). No significant difference in DMRs was observed between the ,40 y group and the $40 y group (DMRs, 21% and 22%, respectively; P 5 1). The DMRs in patients not selected for age were 8% for stage I, 11% for stage IIA, 15% for stage IIB, and 44% for stage III. Conclusion: The DMR was not significantly higher in younger breast cancer patients (,40 y) than in older breast cancer patients ($40 y), ruling out the assumption that undetected metastases at diagnosis explain the poorer outcome of younger women. However, our results highlight the high yield of 18 F-FDG PET/CT for initial breast cancer staging, even in stage II patients, whatever their age. Br east cancers affect women younger than 40 y at rates of 5%-7% (1). Women in this age category have lower breast cancer-specific survival than older women (2). In a large epidemiological study, Gnerlich et al. showed that specific mortality was higher in women younger than 40 y and diagnosed with stage I or II disease than in older women diagnosed with stage I or II disease (3).One possible hypothesis for this higher specific mortality is that initial staging could underestimate distant metastases in low stages more often in women younger than 40 y than in older women. In a recent study, Riedl et al. took advantage of the superiority of 18 F-FDG PET/CT over conventional imaging for the detection of breast cancer metastases (4-8) to examine this hypothesis; they reported relatively high distant metastasis rates (DMRs) in patients youn...

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“…Kurebayashi et al (9) reported that Japanese patients with TNBC are mostly superimposable for disease-free survival (DFS) and overall survival (OS). Lin et al (10) indicated that Taiwanese TNBC patients exhibited a better 5-year OS compared with HER2-positive patients. Yin et al (7) revealed that recurrence-free survival in Chinese TNBC patients was superior to that of HER2-positive patients.…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics and prognostic analysis of triple-negative breast cancer patients

Yuan

Meng

Liu

et al. 2013

Molecular and Clinical Oncology

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Abstract. It is well-established that triple-negative breast cancer (TNBC) is a subtype of breast cancer, characterized by a poor prognosis and aggressive biological behavior. However, the available relevant data on TNBC in non-Western populations are limited. In order to analyze the clinicopathological and molecular biological characteristics and observe survival and prognostic factors, 972 breast cancer patients (156 of whom had TNBC) who received treatment at the First Affiliated Hospital of Medical School of Xi'an Jiaotong University and the First Hospital of China Medical University, between January, 2004 and January, 2007 were retrospectively evaluated. In the univariate analysis, tumor size, TNM stage, axillary lymph node status and recurrence or metastasis were identified as prognostic factors for 7-year disease-free survival (DFS) and overall survival (OS). Our multivariate Cox's regression analysis demonstrated that tumor size and axillary lymph node status were significant prognostic factors for 7-year DFS and OS. Notably, tumor subgroup (TNBC vs. non-TNBC) was a significant prognostic factor associated with 7-year DFS and OS in breast cancer. It was suggested that TNBC exhibited a worse 7-year survival compared with that in non-TNBC patients, most likely due to its more aggressive behavior and insensitivity to specific therapy. IntroductionBreast cancer is the most common malignancy among females (1) and the second most common cause of cancer-related mortality behind lung cancer (2). Due to changes in lifestyle, the incidence of breast cancer, which is currently on the increase in developing countries, including China, has increased significantly. Based on DNA microarray techniques, breast cancer is classified into five subtypes: luminal A, luminal B, normal breast-like, human epidermal growth factor receptor 2 (HER2/neu)-overexpressing and basal-like (3). The basal-like and normal breast-like subtypes, which are immunohistochemically characterized by the lack of expression of the estrogen receptor (ER), progesterone receptor (PgR) and HER2, are defined as triple-negative breast cancer (TNBC) (4).TNBC is a distinct breast cancer subtype, which accounts for ~10-17% of all breast carcinomas (5). TNBC, usually occurring in young females, is generally considered to exhibit an aggressive clinical behavior and poor prognosis, due to the fact that it is insensitive to endocrine and targeted therapy (6). Furthermore, the TNBC subgroup is associated with a higher risk of distant recurrence and mortality compared to its non-triple-negative counterparts, particularly during the first 3-5 years of follow-up (6). However, few studies have been conducted among non-Western populations (7) and the information on the Asian TNBC subtype remains confusing and limited (8). Kurebayashi et al (9) reported that Japanese patients with TNBC are mostly superimposable for disease-free survival (DFS) and overall survival (OS). Lin et al (10) indicated that Taiwanese TNBC patients exhibited a better 5-year OS compared with HER2...

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Triple negative breast carcinoma is a prognostic factor in Taiwanese women

Cited by 34 publications

References 23 publications

Triple-negative breast cancer in Hispanic patients

Triple-negative breast cancer in Hispanic patients

Rate of Distant Metastases on ¹⁸F-FDG PET/CT at Initial Staging of Breast Cancer: Comparison of Women Younger and Older Than 40 Years

Clinical characteristics and prognostic analysis of triple-negative breast cancer patients

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Triple negative breast carcinoma is a prognostic factor in Taiwanese women

Cited by 34 publications

References 23 publications

Triple-negative breast cancer in Hispanic patients

Triple-negative breast cancer in Hispanic patients

Rate of Distant Metastases on 18F-FDG PET/CT at Initial Staging of Breast Cancer: Comparison of Women Younger and Older Than 40 Years

Clinical characteristics and prognostic analysis of triple-negative breast cancer patients

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Rate of Distant Metastases on ¹⁸F-FDG PET/CT at Initial Staging of Breast Cancer: Comparison of Women Younger and Older Than 40 Years