Triple-Negative Breast Cancer, Stem Cells, and African Ancestry

Jiagge, Evelyn; Chitale, Dhananjay; Newman, Lisa A.

doi:10.1016/j.ajpath.2017.06.020

Cited by 42 publications

(35 citation statements)

References 81 publications

(47 reference statements)

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“…23 The shared genetic ancestry between US-born and Western-Africanborn blacks as a consequence of the historic migration is also supported by evidence from population genetics studies. However, the similarity in breast cancer subtype between US-born and Western-African-born blacks, contrasted against the differences with Eastern-African-born blacks, may in part reflect shared ancestry-related risk factors.…”

Section: Discussionmentioning

confidence: 88%

“…Most US-born and Caribbean-born blacks are likely descendants of people who were involuntarily migrated from West Africa to North America during the 16th to 18th centuries, often through the Caribbean. 23 The shared genetic ancestry between US-born and Western-Africanborn blacks as a consequence of the historic migration is also supported by evidence from population genetics studies. 11,24 Ancestry analyses among black individuals living in Chicago, Baltimore, Pittsburgh, and North Carolina have shown that ancestry of African Americans is predominantly from Niger-Kordofanian (approximately 71%), the most common ancestry in Western Africa, followed by European (approximately 13%), and other African (approximately 8%) populations.…”

Section: Discussionmentioning

confidence: 88%

“…The nonsignificant difference in PRR by Census region (P for heterogeneity = .10) may be related to unique immigration patterns of African immigrants to US cities 33 and the heterogeneous composition of national origins in regionally defined, foreign-born populations by Census region (data not shown) or simply unreliable measures owing to small sample sizes. Results from epidemiological studies conducted in Sub-Saharan Africa are not entirely consistent and not directly comparable because of differing analytical methods and variable sample sizes 23,[34][35][36][37][38][39] ; however, preliminary evidence from these studies shows geographical heterogeneity in breast cancer subtype prevalence, with the proportion of triple-negative breast cancer reported to be relatively lower in East Africa (range, 23%-44%) than in West Africa (range, 27%-61%), 38 in accordance with our findings from the corresponding foreign-born black women with breast cancer in the United States.…”

Section: Discussionmentioning

confidence: 96%

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Breast cancer subtypes among Eastern‐African–born black women and other black women in the United States

Sung

DeSantis

Fedewa

et al. 2019

Cancer

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BACKGROUND:A previous study reported that Eastern-African-born black women in the United States had lower prevalence of estrogen receptor-negative breast cancer than those in US-born and Western-African-born black women, among whom the prevalence was similar. It is unknown whether the prevalence of triple-negative breast cancer (negative for estrogen receptor, progesterone receptor, and human epidermal growth factor 2 receptor) among black women in the United States differs similarly by birthplace. METHODS: In the National Program of Cancer Registries and US Cancer Statistics, the authors identified 65,211 non-Hispanic black women who were diagnosed with invasive breast cancer from 2010 through 2015 and were recorded as being born in the United States, East Africa, West Africa, or the Caribbean. The prevalence of triple-negative and hormone receptor-negative breast cancer (negative for estrogen receptor and progesterone receptor) among each group of foreign-born black women was compared with that among US-born black women and was expressed as the adjusted prevalence rate ratio, accounting for sociodemographic and tumor characteristics. Analyses were stratified by Census region, and region-specific estimates were summarized using random-effects meta-analyses. RESULTS: Compared with US-born black women, the prevalence rate ratio of triple-negative breast cancer was 0.92 (95% CI, 0.81-1.04) among Western-African-born, 0.87 (95% CI, 0.78-0.98) among Caribbean-born, and 0.53 (95% CI, 0.37-0.77) among Eastern-African-born black women. Patterns for hormone receptor-negative tumors were generally similar, although the differences between populations were attenuated. The test for heterogeneity by Census region was not significant in any of the comparisons (all P for heterogeneity >.05). CONCLUSIONS: The prevalence of triple-negative breast cancer among black women in the United States varied significantly by birthplace, particularly among Eastern-African-born black women. These findings underscore the importance of considering geographic origin in studies characterizing breast cancer among women of African descent in the United States and elsewhere. Cancer 2019;125:3401-3411.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 96%

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Breast cancer subtypes among Eastern‐African–born black women and other black women in the United States

Sung

DeSantis

Fedewa

et al. 2019

Cancer

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“…TNBC is highly aggressive and associated with poor prognosis. Jiagge et al 6 review epidemiological research that compares socioeconomic status and tumor biology and describe the increased risk for TNBC in women of African descent. They review the genetics and biology of TNBC and discuss how it contributes to the overall disparities in breast cancer outcome.…”

Section: Triple-negative Breast Cancer and African Ancestrymentioning

confidence: 99%

The Science of Cancer Health Disparities

Gardner

2018

The American Journal of Pathology

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“…The onset of race-group mortality rate disparities coincides with the advent of hormone-targeted therapies [5] that are now standard-of-care for hormone receptor-positive tumors. Compared to women of European descent, AA women [4,[6][7][8][9][10][11][12][13] and women of African descent world-wide [9,[14][15][16] have a higher incidence of triple-negative breast cancer (TNBC) [17][18][19][20][21], which is characterized by the absence of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2). Therefore, in the context of standardizing ER/PR-and HER2-targeted therapies, the divergence of AA vs EA mortality likely unmasked population-level differences in tumor biology, which we have previously shown to correlate with genetic ancestry [22].…”

Section: Introductionmentioning

confidence: 99%

Identification of Distinct Heterogenic Subtypes and Molecular Signatures Associated With African Ancestry in Triple Negative Breast Cancer Using Quantified Genetic Ancestry Models in Admixed Race Populations

Davis¹,

Martini²,

Newman³

et al. 2020

Preprint

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Triple negative breast cancers (TNBCs) are molecularly heterogeneous, and the link between their aggressiveness with African ancestry is not established. We investigated primary TNBCs for gene expression among self-reported race (SRR) groups of African American (AA, n=42) and European American (EA, n=33) women. Using The Cancer Genome Atlas (TCGA) approaches, we analyzed RNA sequencing data to measure changes in genome-wide expression and used logistic regressions to identify ancestry-associated gene expression signatures. To determine global ancestry, GATK best practices were followed for variant calling, and used the 1000 Genomes Project as reference data. We identified >150 African ancestry-associated genes and found that, compared to SRR, quantitative genetic analysis was a more robust method to identify racial/ethnic-specific genes that were differentially expressed. A subset of African ancestry-specific genes that were upregulated in TNBCs of our AA patients were validated in TCGA data. In AA patients, there was a higher incidence of basal-like 2 tumors and altered TP53, NFB1, and AKT pathways. The distinct distribution of TNBC subtypes and altered oncologic pathways show that the ethnic variations in TNBCs are driven by shared genetic ancestry. Thus, to appreciate the molecular diversity of TNBCs, tumors from patients of various ancestral origins should be evaluated.

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Triple-Negative Breast Cancer, Stem Cells, and African Ancestry

Cited by 42 publications

References 81 publications

Breast cancer subtypes among Eastern‐African–born black women and other black women in the United States

Breast cancer subtypes among Eastern‐African–born black women and other black women in the United States

The Science of Cancer Health Disparities

Identification of Distinct Heterogenic Subtypes and Molecular Signatures Associated With African Ancestry in Triple Negative Breast Cancer Using Quantified Genetic Ancestry Models in Admixed Race Populations

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