This work identifies the key factors influencing the success of multidisciplinary, interdisciplinary, and trans-disciplinary R&D projects in transition economies by integrating knowledge management, organizational, inter/intra-collaboration (open-innovation), and leadership perspectives, while also addressing the perspective of the science of team science, which is an integrative approach to R&D. This is followed by providing the major sub-constructs of team science and policy implications to better facilitate multidisciplinary, interdisciplinary, and transdisciplinary R&D projects in knowledge-based transition economies.