Triple analyzer mass spectrometry for high resolution MS/MS studies

Gross, Michael L.; Chess, Edward K.; Lyon, P. A.; Crow, Frank W.; Evans, S.; Tudge, Harold

doi:10.1016/0020-7381(82)80069-7

Cited by 222 publications

(75 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, the close but not perfect analysis indicates the structure 25, rather than a monomeric species. The mass spectrum of 25 was most informative and, after much effort using the FAB techniques (27) and using thioglycerol as solvent, a parent ion with m / z centered at 1859.5 amu was observed. A major fragment ion at 1816 (M ' -43) was indicative of loss of an isopropyl group, consistent with structure 25.…”

mentioning

confidence: 99%

Metallophthalocyanine dimers incorporating five-atom covalent bridges

Leznoff¹,

Marcuccio²,

Greenberg³

et al. 1985

Can. J. Chem.

159

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 99%

Metallophthalocyanine dimers incorporating five-atom covalent bridges

Leznoff¹,

Marcuccio²,

Greenberg³

et al. 1985

Can. J. Chem.

159

View full text Add to dashboard Cite

show abstract

“…1 H NMR: υ 2.33 (s, 3H), 3.99 (s, 3H), 7.18 (s, 1H), 7.80 (s, 1H). 13 C NMR: υ 16. 28,56.77,105.76,126.99,132.52,134.71,143.21,161.13.…”

Section: Synthesis Of Compoundsmentioning

confidence: 99%

“…MI 11 and CAD 12 spectra were acquired with a Kratos MS-50TA triple-analyser mass spectrometer 13 of E 1 BE 2 design. The MI and CAD experiments were performed by selecting the precursor ion with MS1, which is comprised of E 1 B, and scanning MS2, comprised solely of E 2 , to record a spectrum of the product ions.…”

Section: Experimental Mass Spectrometrymentioning

confidence: 99%

See 1 more Smart Citation

Mass spectra of 1,2-alkylenedioxy-substituted and related benzofurazans and benzofuroxans: differentiation between linear and angular isomers

Takakis¹,

Tsantali²,

Haas³

et al. 1999

J. Mass Spectrom.

Self Cite

View full text Add to dashboard Cite

“…For all this early work, sector instruments were used exclusively and CID was performed at high kinetic energies. There was a lot of research effort focused on MS/MS sector instrumentation at this time [13][14][15][16][17][18][19][20][21][22]. However, in 1978, Yost and Enke published the first results using CID in a triple quadrupole system for MS/MS [23].…”

Section: Beam-beam Hybrid Instrumentsmentioning

confidence: 99%

Hybrid mass spectrometers for tandem mass spectrometry

Glish

Burinsky

2008

J. Am. Soc. Mass Spectrom.

101

View full text Add to dashboard Cite

Mass spectrometers that use different types of analyzers for the first and second stages of mass analysis in tandem mass spectrometry (MS/MS) experiments are often referred to as "hybrid" mass spectrometers. The general goal in the design of a hybrid instrument is to combine different performance characteristics offered by various types of analyzers into one mass spectrometer. These performance characteristics may include mass resolving power, the ion kinetic energy for collision-induced dissociation, and speed of analysis. This paper provides a review of the development of hybrid instruments over the last 30 years for analytical applications. (J Am Soc Mass Spectrom 2008, 19, 161-172) © 2008 American Society for Mass Spectrometry T andem mass spectrometry (MS/MS), in a very generic description, is a process in which an ion formed in an ion source is mass-selected in the first stage of analysis, reacted, and then the charged products from the reaction are analyzed in the second stage of analysis. The type and quality of data that is obtained can vary greatly depending upon the type of analyzer used in the first and second stages of analysis, and the type of reaction performed between the stages of analysis. The reactions that can be done also can depend upon the type of analyzer. Over the years there have been a variety of means developed to measure the mass-to-charge ratio of gas-phase ions. The most common methods involve: dispersion based on ion momentum or kinetic energy (magnetic and electric sector instruments); separation in time based on ion velocity (time-of-flight); transmission through an electrodynamic field (quadrupole mass filter); and periodic motion in a magnetic or electrodynamic field (ion traps). There are differences in the experimental parameters associated with these various analysis methods that are pertinent to the MS/MS experiment. Some parameters are obvious, typically related to the performance of the mass analyzer while others are more subtle, related to the reactions/chemistry occurring between the stages of analysis. Many times these different parameters are used to categorize MS/MS experiments.One parameter is the ion kinetic energy. Sector and time-of-flight (TOF) instruments typically operate at "high" ion kinetic energies (5-20 keV), whereas "low" ion kinetic energies (Ͻ50 eV) are typical in quadrupole mass filters and ion traps. The ion kinetic energy is an important parameter in MS/MS experiments because the most common reaction involves colliding the ion of interest with a target gas atom or molecule. When performing ion-neutral collision experiments, the possible reactions that can be accessed (e.g., collisioninduced dissociation, collisional cooling, charge permutation, ion/molecule reaction) depends upon the ion kinetic energy. The appearance of the MS/MS spectrum can change drastically as a function of the collision (ion kinetic) energy. A related factor that is equally important, but often not considered, is the time frame of the experiment, that is, the elapsed time bet...

show abstract

Triple analyzer mass spectrometry for high resolution MS/MS studies

Cited by 222 publications

References 12 publications

Metallophthalocyanine dimers incorporating five-atom covalent bridges

Metallophthalocyanine dimers incorporating five-atom covalent bridges

Mass spectra of 1,2-alkylenedioxy-substituted and related benzofurazans and benzofuroxans: differentiation between linear and angular isomers

Hybrid mass spectrometers for tandem mass spectrometry

Contact Info

Product

Resources

About