Triphasic polymeric corneal coating gel versus a balanced salt solution irrigation during cataract surgery: A postoperative anterior segment optical coherence tomography analysis and confocal microscopy evaluation

Mencucci, Rita; Cennamo, Michela; Favuzza, Eleonora; Rechichi, Miguel; Rizzo, Stanislao

doi:10.1016/j.jcrs.2019.03.002

Cited by 8 publications

(7 citation statements)

References 19 publications

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“…Pre-, intra-, and postoperative risk factors may alter ocular surface homeostasis, resulting in tear film instability, hyperosmolarity, and inflammation of the ocular surface [ 4 , 13 , 15 ]. Consistently, it has been confirmed that phacoemulsification triggers inflammatory stress on eye tissues [ 16 , 17 ]. In addition, the reduced tear production and increased evaporation increase the osmolarity of the tear film.…”

Section: Discussionmentioning

confidence: 65%

Alpha-Glycerylphosphorylcholine and D-Panthenol Eye Drops in Patients Undergoing Cataract Surgery

Martone

Balestrazzi

Ciprandi

et al. 2022

Journal of Ophthalmology

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Cataract surgery is widespread. The surgical procedure is associated with damage to the epithelial barrier and interruption of the corneal innervation. In addition, pathological events sustain signs and symptoms that may persist for a long time. Recently, a fixed combination of alpha-glycerylphosphorylcholine and D-Panthenol (Oftassiale) has been available as eye drops. The present study investigated the effects of an Oftassiale therapy in 20 patients undergoing cataract surgery. A comparison group included 20 patients treated with topical hyaluronic acid. Standard prophylactic and anti-inflammatory treatment was prescribed to all patients. Clinical signs and symptoms were assessed over time. In vivo confocal microscopy (IVCM) was performed accordingly. Oftassiale treatment significantly reduced clinical features and improved IVCM outcomes. In addition, therapy was well-tolerated, and no clinically significant adverse events occurred. In conclusion, this study confirmed that IVCM helps assess the tunnel after cataract surgery due to its ability to provide microscopic details in vivo. Topical therapy with alpha-glycerylphosphorylcholine and D-Panthenol eye drops promoted and stabilized the reepithelialization process. This fixed combination also accelerated and modulated the repair of the corneal innervation. Moreover, this treatment was well-tolerated and safe.

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Section: Discussionmentioning

confidence: 65%

Alpha-Glycerylphosphorylcholine and D-Panthenol Eye Drops in Patients Undergoing Cataract Surgery

Martone

Balestrazzi

Ciprandi

et al. 2022

Journal of Ophthalmology

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“…A polysaccharide gel of hydroxypropyl methylcellulose, xanthan gum, and carrageenan (eyeDRO; Alchimia, Italy) on the cornea in 28 eyes achieved return of TBUTs to preoperative levels by day 5 as compared to day 30 in the BSS group of 26 patients. Concordantly, OSDI returned to preoperative values after 15 days in the gel group and 30 days in the BSS group [99]. Reductions in TBUT, corneal ocular staining score, and OSDI are also reported with DisCoVisc (Alcon Laboratories, Fort Worth, TX, USA) in 13 patients (All P < .01) as compared to a BSS group 1 week postoperatively [100].…”

Section: Intraoperative Considerationsmentioning

confidence: 84%

Cataract Surgery and Dry Eye

Ooi,

Leung,

Xiong

et al. 2023

Cataract - An Update on Clinical and Surgical Management

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This chapter outlines preoperative, intraoperative, and postoperative considerations with respect to dry eye (DE) and its impact on cataract surgery, to guide optimization of patient satisfaction with their refractive outcomes. A systematic review was performed and reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. MEDLINE (Ovid), EMBASE (Ovid), Cochrane Library, PubMed, and Scopus, from the date of inception (1946) until 3rd June 2023, were searched. Dry eye and ametropia are among the most common causes of dissatisfaction after cataract surgery and also the most amenable to successful conservative management. Dry eye can reduce contrast sensitivity and increase dysphotopsias in multifocal intraocular lens patients. Several pathophysiological changes occur during and after surgery that influence DE manifestation postoperatively. Dry eye symptoms and signs generally normalize at around 3 months in both normal and DE patients, but a significant minority have ongoing discomfort. A number of systemic and ocular conditions are identified, which may aid in preoperative risk evaluation. Preoperative symptom evaluation, examination, and investigation techniques are also summarized and their influence on refractive outcomes emphasized. Current preoperative, intraoperative, and postoperative measures to decrease burden are additionally evaluated.

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“…Although phacoemulsifcation is a safe surgical procedure, the corneal surface is exposed to several intraoperative (e.g., mechanical intraoperative trauma, multiple irrigations, etc.) and postoperative (e.g., multiple doses of eye drops containing preservatives) factors, entailing epithelial remodeling [201]. Some studies with diferent designs have evaluated ETM changes after cataract surgery [133,[201][202][203], almost all reporting an increase in the central and midperipheral CET with a gradual decrease to baseline levels within a month [133,[201][202][203].…”

Section: Cataract Surgerymentioning

confidence: 99%

“…and postoperative (e.g., multiple doses of eye drops containing preservatives) factors, entailing epithelial remodeling [201]. Some studies with diferent designs have evaluated ETM changes after cataract surgery [133,[201][202][203], almost all reporting an increase in the central and midperipheral CET with a gradual decrease to baseline levels within a month [133,[201][202][203]. However, their reported back-to-baseline time points varied; some studies report a return to preoperative levels within 3-7 days [202,203], while some others report longer durations ranging from 5-15 days [201,204] to 4 weeks [133].…”

Section: Cataract Surgerymentioning

confidence: 99%

“…Some studies with diferent designs have evaluated ETM changes after cataract surgery [133,[201][202][203], almost all reporting an increase in the central and midperipheral CET with a gradual decrease to baseline levels within a month [133,[201][202][203]. However, their reported back-to-baseline time points varied; some studies report a return to preoperative levels within 3-7 days [202,203], while some others report longer durations ranging from 5-15 days [201,204] to 4 weeks [133]. In addition, CET reduction to baseline levels can take longer in people with diabetes [202].…”

Section: Cataract Surgerymentioning

confidence: 99%

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Corneal Epithelial Thickness Mapping: A Major Review

Abtahi,

Beheshtnejad,

Latifi

et al. 2024

Journal of Ophthalmology

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The corneal epithelium (CE) is the outermost layer of the cornea with constant turnover, relative stability, remarkable plasticity, and compensatory properties to mask alterations in the underlying stroma. The advent of quantitative imaging modalities capable of producing epithelial thickness mapping (ETM) has made it possible to characterize better the different patterns of epithelial remodeling. In this comprehensive synthesis, we reviewed all available data on ETM with different methods, including very high-frequency ultrasound (VHF-US) and spectral-domain optical coherence tomography (SD-OCT) in normal individuals, corneal or systemic diseases, and corneal surgical scenarios. We excluded OCT studies that manually measured the corneal epithelial thickness (CET) (e.g., by digital calipers) or the CE (e.g., by confocal scanning or handheld pachymeters). A comparison of different CET measuring technologies and devices capable of producing thickness maps is provided. Normative data on CET and the possible effects of gender, aging, diurnal changes, refraction, and intraocular pressure are discussed. We also reviewed ETM data in several corneal disorders, including keratoconus, corneal dystrophies, recurrent epithelial erosion, herpes keratitis, keratoplasty, bullous keratopathy, carcinoma in situ, pterygium, and limbal stem cell deficiency. The available data on the potential role of ETM in indicating refractive surgeries, planning the procedure, and assessing postoperative changes are reviewed. Alterations in ETM in systemic and ocular conditions such as eyelid abnormalities and dry eye disease and the effects of contact lenses, topical medications, and cataract surgery on the ETM profile are discussed.

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Triphasic polymeric corneal coating gel versus a balanced salt solution irrigation during cataract surgery: A postoperative anterior segment optical coherence tomography analysis and confocal microscopy evaluation

Cited by 8 publications

References 19 publications

Alpha-Glycerylphosphorylcholine and D-Panthenol Eye Drops in Patients Undergoing Cataract Surgery

Alpha-Glycerylphosphorylcholine and D-Panthenol Eye Drops in Patients Undergoing Cataract Surgery

Cataract Surgery and Dry Eye

Corneal Epithelial Thickness Mapping: A Major Review

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