Abstract:The Type Six Secretion System (T6SS) is a bacterial toxin-delivery system targeting bacterial cells which neighbor the donor, promoting recipient cell death. The T6SS is widely conserved among Gram-negative bacteria and may be a central determinant in bacterial fitness in polymicrobial communities of particular relevance to chronic infection. Sequence homology of secretion system components to the T4 bacteriophage tail spike, cryoEM reconstructions of the secretion system and fluorescence imaging are all consi… Show more
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