Tripe palms and cancer

Cohen, Philip R.; Grossman, Marc E.; Silvers, David N.; Kurzrock, Razelle

doi:10.1016/0738-081x(93)90114-r

Cited by 61 publications

(51 citation statements)

References 43 publications

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“…The condition is characterized by diffuse, yellowish palmar hyperkeratosis, with enhancement of the epidermal ridges on the hands (dermatoglyphics), resembling intestinal villosities. Cohen 15 reported the association of TP with internal neoplasia in 69/77 cases (90%). Andreev 2 referred to TP and LT sign as clinical variants of ANM; however, cases of both conditions have been reported in which ANM was not present.…”

Section: Discussionmentioning

confidence: 99%

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Papilomatose cutânea florida e acantose nigricante maligna reveladoras de neoplasia gástrica

Brinca

Cardoso

Brites

et al. 2011

An. Bras. Dermatol.

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This paper reports the case of a 57-year-old, previously healthy male with no systemic symptoms who over a short period of time developed multiple wart-like lesions on his trunk, limbs and face, typical lesions of acanthosis nigricans in the major body folds and tripe palms. Diagnostic tests revealed a metastatic gastric adenocarcinoma. Despite the implementation of therapy, which had a transient effect on the tumor and skin lesions, the patient died in 14 months. The association of these three paraneoplastic dermatoses (florid cutaneous papillomatosis, acanthosis nigricans maligna and tripe palms) in the same patient, apparently with a common pathogenic mechanism, is noteworthy. Keywords: Acanthosis nigricans, paraneoplastic syndromes; Stomach neoplasms Resumo: Apresenta-se o caso clínico de um doente de 57 anos, previamente saudável, sem sintomatologia sistêmica, que, num curto intervalo de tempo, desenvolve múltiplas lesões semelhantes a verrugas virais no tronco, membros e face, lesões típicas de acantose nigricante nas grandes pregas e uma queratodermia difusa palmar com paquidermatoglifia. Os exames complementares de diagnóstico revelaram uma neoplasia gástrica metastizada. Apesar da instituição da terapêutica, com efeito transitório na neoplasia e nas lesões cutâneas, o doente viria a falecer em 14 meses. Salientamos a associação destas três dermatoses paraneoplásicas num mesmo paciente: papilomatose cutânea florida, acantose nigricante maligna e tripe palms que parecem ter um mecanismo patogênico comum.

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Section: Discussionmentioning

confidence: 99%

“…Andreev 2 referred to TP and LT sign as clinical variants of ANM; however, cases of both conditions have been reported in which ANM was not present. 15 These paraneoplastic dermatoses may be found prior to or at the time of diagnosis of the primary malignancy or, in rare cases, later. Usually, progression accompanies evolution of the tumor.…”

Section: Discussionmentioning

confidence: 99%

Papilomatose cutânea florida e acantose nigricante maligna reveladoras de neoplasia gástrica

Brinca

Cardoso

Brites

et al. 2011

An. Bras. Dermatol.

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“…"Tripe palms" is also known as acanthosis palmaris, pachydermatoglyphy (PDG) or palmar hyperkeratosis [220] . This condition is characterized by a yellowish rugose hypertrophy of the palms and sometimes the soles, leading to an exaggeration of the skin lines [218,221] . Tripe palms are usually associated with AN.…”

Section: Acanthosis Nigricans Tripe Palms and The Sign Of Lesertrélatmentioning

confidence: 99%

“…Tripe palms are usually associated with AN. More than 90% of cases are associated with neoplasms; in the majority of these cases, lung and gastric cancers are the underlying malignancies [218,221] . The sign of Leser-Trélat (LT) refers to the eruption of numerous seborrheic keratoses [215] .…”

Section: Acanthosis Nigricans Tripe Palms and The Sign Of Lesertrélatmentioning

confidence: 99%

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Paraneoplastic syndromes associated with lung cancer

1993

Lung Cancer

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Paraneoplastic syndromes are signs or symptoms that occur as a result of organ or tissue damage at locations remote from the site of the primary tumor or metastases. Paraneoplastic syndromes associated with lung cancer can impair various organ functions and include neurologic, endocrine, dermatologic, rheumatologic, hematologic, and ophthalmological syndromes, as well as glomerulopathy and coagulopathy (Trousseau's syndrome). The histological type of lung cancer is generally dependent on the associated syndrome, the two most common of which are humoral hypercalcemia of malignancy in squamous cell carcinoma and the syndrome of inappropriate antidiuretic hormone secretion in small cell lung cancer. The symptoms often precede the diagnosis of the associated lung cancer, especially when the symptoms are neurologic or dermatologic. The proposed mechanisms of paraneoplastic processes include the aberrant release of humoral mediators, such as hormones and hormone-like peptides, cytokines, and antibodies. Treating the underlying cancer is generally the most effective therapy for paraneoplastic syndromes, and treatment soon after symptom onset appears to offer the best potential for symptom improvement. In this article, we review the diagnosis, potential mechanisms, and treatments of a wide variety of paraneoplastic syndromes associated with lung cancer.

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Association of Transient Palmoplantar Keratoderma With Clinical and Immunologic Characteristics of Bullous Pemphigoid

et al. 2019

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IMPORTANCE Development of transient palmoplantar keratoderma (PPK) with bullous pemphigoid (BP) has only been described in 2 isolated case reports. The clinical significance and the pathophysiologic mechanisms of this association are unknown. OBJECTIVE To examine the clinical characteristics and immunological profile of patients with BP who develop transient PPK and analyze therapeutic options and outcomes.DESIGN, SETTING, AND PARTICIPANTS In this case series, patients with BP who developed acquired, transient PPK, and were treated at a single institution from January 1, 2015, through December 31, 2017, were studied. MAIN OUTCOMES AND MEASURES Clinical and immunological activity of BP, treatment administrated before and after PPK appearance, and patient outcomes.RESULTS Six patients with BP and transient PPK were identified and included in the study. There were 5 women and 1 man with a mean age of 72 years. At baseline, all patients had a generalized, multibullous BP and high serum anti-BP180 antibodies (mean, 130 U/mL; range, 73-150), whereas anti-BP230 antibodies were elevated in only 1 case. The PPK appeared a mean 6.2 (range, 2-12) months after BP diagnosis, following a prolonged period of disease activity with recurrent flares. When the PPK occurred, BP was uncontrolled on therapy (mean Bullous Pemphigoid Disease Activity Index [BPDAI] score, 57; range, 34-105; mean anti-BP180 antibodies titer, 122 U/mL; range, 81-150). On administration of additional systemic immunosuppressive therapies, the PPK healed progressively in a mean 4.3 months (range, 2-9), along with BP clinical remission in 4 of 6 patients. No relationship was found between PPK occurrence and anti-BP180/230 antibodies profiles. In contrast, blister fluids collected at the time of PPK displayed a much higher level of interleukin 1β (IL-1β) compared with those collected in the absence of PKK. Expression of IL-17A, IL-17F, and IL-22 was also enhanced in the blister fluid of patients with BP who had PPK CONCLUSIONS AND RELEVANCE To our knowledge, this is the first report of 6 cases of BP with transient PPK with extensive immunological investigation. The PPK appeared after a prolonged period of clinical BP activity punctuated with recurrent relapses, was transient, and healed after BP control with additional immunosuppressive therapy. Enhanced expression of a particular cytokine panel in the blister fluid at time of PPK could support keratinocyte proliferation as described in patients with psoriasis. Transient PPK could represent a clinical marker of severe, treatment-resistant BP.

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Tripe palms and cancer

Cited by 61 publications

References 43 publications

Papilomatose cutânea florida e acantose nigricante maligna reveladoras de neoplasia gástrica

Papilomatose cutânea florida e acantose nigricante maligna reveladoras de neoplasia gástrica

Paraneoplastic syndromes associated with lung cancer

Association of Transient Palmoplantar Keratoderma With Clinical and Immunologic Characteristics of Bullous Pemphigoid

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