Tripartite motif family – its role in tumor progression and therapy resistance: a review
Yongqi Zhang,
Ying Guan,
Shuxiang Wang
et al.
Abstract:Purpose of review
In this review, we summarized published articles on the role of tripartite motif (TRIM) family members in the initiation and development of human malignancies.
Recent findings
The ubiquitin-proteasome system (UP-S) plays a critical role in cellular activities, and UP-S dysregulation contributes to tumorigenesis. One of the key regulators of the UP-S is the tripartite motif TRIM protein family, most of which are active E3 ubiquitin liga… Show more
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