Tripartite motif-containing protein 6 facilitates growth and migration of breast cancer through degradation of STUB1

Wei, Chuanchao; Wu, Jiayue; Liu, Weiyan; Lu, Jingfeng; Li, Hongchang; Hai, Benjun

doi:10.4081/ejh.2021.3214

Cited by 20 publications

(18 citation statements)

References 29 publications

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“…The expression levels of NEAT1 (LC_S149) and NEAT1 (LC_S216) in LUAD tissues were significantly decreased ( Figure 10 ). Figure 11 shows that NEAT1 overexpression in LUAD tissues was related to dismal prognosis of LUAD patients via meta-analysis ( 14 - 19 ). The constructed TRIM6 network mechanism provides a new regulatory mechanism for LUAD progression ( Figure S6 ).…”

Section: Resultsmentioning

confidence: 99%

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LncRNA NEAT1-miR-101-3p/miR-335-5p/miR-374a-3p/miR-628-5p-TRIM6 axis identified as the prognostic biomarker for lung adenocarcinoma via bioinformatics and meta-analysis

Ding¹,

Li²,

Shi³

et al. 2021

Transl Cancer Res TCR

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Background Overexpression of the tripartite motif containing 6 (TRIM6) is associated with dismal prognosis in cancer patients, but its exact roles in lung adenocarcinoma (LUAD) have not been reported. Methods The roles of TRIM6 are identified by using The Cancer Genome Atlas (TCGA), TIMER2, Gene Expression Omnibus (GEO), etc., and the regulatory networks and related-prognostic biomarkers of TRIM6 are identified via the ENCORI and LNCAR databases in the LUAD progression. Results TRIM6 expression level in LUAD tissues was significantly increased. TRIM6 over-expression level in LUAD patients was associated with smoking, clinical stage, histological type, lymph node metastasis, TP53 mutation and dismal prognosis, and related to prognosis-related age, race, sex, clinical stage and tumor purity of LUAD patients. TRIM6 overexpression was associated with the levels of CD8 + T cells, macrophages, neutrophils and myeloid dendritic cells, and correlated with the levels of LUAD immune cell markers CD8A, IRF5, CD163, VSIG4, MS4A4A, ITGAM, HLA-DPA1, NRP1, ITGAX, etc. TRIM6 might influence the progression of LUAD by regulating homologous recombination, oocyte meiosis, and ubiquitin-mediated proteolysis. LUAD patients with overexpression of miR-101-3p, miR-335-5p, miR-374a-3p, miR-628-5p, and NEAT1 had a poor prognosis. Conclusions NEAT1-miR-101-3p/335-5p/374a-3p/628-5p-TRIM6 network, which we constructed from our results, might be an important factor in the dismal prognosis of LUAD patients.

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Section: Resultsmentioning

confidence: 99%

“…The tripartite motif containing 6 (TRIM6) also plays a crucial role in carcinogenesis (13)(14)(15). It is upregulated in colorectal cancer (CRC) and its expression level is an independent predictor of dismal prognosis in CRC patients.…”

Section: Introductionmentioning

confidence: 99%

LncRNA NEAT1-miR-101-3p/miR-335-5p/miR-374a-3p/miR-628-5p-TRIM6 axis identified as the prognostic biomarker for lung adenocarcinoma via bioinformatics and meta-analysis

Ding¹,

Li²,

Shi³

et al. 2021

Transl Cancer Res TCR

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“…TRIM6, TRIM11, TRIM18 (MID1), TRIM24, TRIM28, TRIM31, TRIM59 and TRIM66 were reported oncogenes while TRIM16, TRIM37, TRIM45 were reported tumor suppressors in different types of cancers. 3,11,[33][34][35] TRIM52 was reported oncogene in ovarian cancer, 36 hepatocellular carcinoma, 37 but tumor suppressor in glioma. 38 To investigate the role these TRIMs play in HCC, we analyzed the correlation of the gene expressions with pathological stage and survival.…”

Section: Discussionmentioning

confidence: 99%

Identification Prognostic Value and Correlation with Tumor-Infiltrating Immune Cells of Tripartite-Motif Family Genes in Hepatocellular Carcinoma

Tang

Nie

et al. 2022

IJGM

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Background: Hepatocellular carcinoma (HCC) is one of the most common and mortality types of malignant tumors in the world. The Tripartite-Motif (TRIM) protein family consists of more than 80 proteins with E3 ubiquitin ligase activity. Increasing studies have found that TRIM family proteins play an extremely important role in the occurrence and development of tumors. However, the expression and prognostic values of TRIMs in HCC have not been clarified. Methods: We used bioinformatic methods to explore the potential function of TRIM family genes in the HCC. Web servers ONCOMINE, UALCAN, GEPIA, cBioPortal, STRING, DAVID 6.8 and TIMER were used in this research. Results: We screened TRIM1-76 and found the expressions of TRIM6, TRIM11, TRIM16, TRIM18(MID1), TRIM24, TRIM28, TRIM31, TRIM37, TRIM45, TRIM52, TRIM59, TRIM66 were significantly changed in HCC. Among them, TRIM24, TRIM28, TRIM37, TRIM45 and TRIM59 had significant effects on pathological stages, overall survival and disease free survival. Functions of these genes are primarily related to transcriptional misregulation in cancer, p53 signaling pathway, alcoholism and viral carcinogenesis, FoxO signal pathway, PI3K-AKT pathway, cell cycle, microRNAs in cancer. Our results showed the significant correlation between TRIMs expression and infiltration of innate immune cells (macrophages, neutrophils, and dendritic cells). Conclusion: Our result provides novel insights into the function of TRIM family genes, which may be used as potential references for drug targets and accurate survival predictions in patients with HCC.

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“…The overexpression of TRIM6 in LUAD tissues indicated a poor prognosis [ 63 ]. TRIM6 accelerated the growth and metastasis of breast cancer [ 64 ] and colorectal cancer [ 65 , 66 ]. UHRF1 is a novel diagnostic marker of lung cancer, UHRF1 controls the cell cycle by silencing tumor suppressor genes, and the overexpressed UHRF1 was related to the poor survival of NSCLC patients [ 67 , 68 , 69 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of Ubiquitin-Related Gene-Pair Signatures for Predicting Tumor Microenvironment Infiltration and Drug Sensitivity of Lung Adenocarcinoma

Jia

et al. 2022

Cancers

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Lung adenocarcinoma (LUAD) is a common pathological type of lung cancer worldwide, and new biomarkers are urgently required to guide more effective individualized therapy for patients. Ubiquitin-related genes (UbRGs) partially participate in the initiation and progression of lung cancer. In this study, we used ubiquitin-related gene pairs (UbRGPs) in tumor tissues to access the function of UbRGs in overall survival, immunocyte infiltration, and tumor mutation burden (TMB) of patients with LUAD from The Cancer Genome Atlas (TCGA) database. In addition, we constructed a prognostic signature based on six UbRGPs and evaluated its performance in an internal (TCGA testing set) and an external validation set (GSE13213). The prognostic signature revealed that risk scores were negatively correlated with the overall survival, immunocyte infiltration, and expression of immune checkpoint inhibitor-related genes and positively correlated with the TMB. Patients in the high-risk group showed higher sensitivity to partially targeted and chemotherapeutic drugs than those in the low-risk group. This study contributes to the understanding of the characteristics of UbRGPs in LUAD and provides guidance for effective immuno-, chemo-, and targeted therapy.

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Tripartite motif-containing protein 6 facilitates growth and migration of breast cancer through degradation of STUB1

Cited by 20 publications

References 29 publications

LncRNA NEAT1-miR-101-3p/miR-335-5p/miR-374a-3p/miR-628-5p-TRIM6 axis identified as the prognostic biomarker for lung adenocarcinoma via bioinformatics and meta-analysis

LncRNA NEAT1-miR-101-3p/miR-335-5p/miR-374a-3p/miR-628-5p-TRIM6 axis identified as the prognostic biomarker for lung adenocarcinoma via bioinformatics and meta-analysis

Identification Prognostic Value and Correlation with Tumor-Infiltrating Immune Cells of Tripartite-Motif Family Genes in Hepatocellular Carcinoma

Identification of Ubiquitin-Related Gene-Pair Signatures for Predicting Tumor Microenvironment Infiltration and Drug Sensitivity of Lung Adenocarcinoma

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