In ATM systems, the massive number of interacting entities makes it difficult to predict the system-wide effects that innovations might have. Here, we present the approach proposed by the project Domino to assess and identify the impact that innovations might bring for the different stakeholders, based on agent-based modelling and complex network science. By investigating a dataset of US flights, we first show that existing centrality and causality metrics are not suited in characterising the effect of delays in the system. We then propose generalisations of such metrics that we prove suited to ATM applications. Then, we introduce the Agent Based Model used in Domino to model scenarios mirroring different system innovations which change the agents' actions and behaviour. We focus on a specific innovation related to flight arrival coordination and we show the insights on its effects at the network level obtained by applying the proposed new metrics.