TRIP-Br2 promotes oncogenesis in nude mice and is frequently overexpressed in multiple human tumors

Abstract

Background: Members of the TRIP-Br/SERTAD family of mammalian transcriptional coregulators have recently been implicated in E2F-mediated cell cycle progression and tumorigenesis. We, herein, focus on the detailed functional characterization of the least understood member of the TRIP-Br/SERTAD protein family, TRIP-Br2 (SERTAD2).

Sertad1 promotes prostate cancer progression through binding androgen receptor ligand binding domain

“…SERTA domain‐containing protein 1 (Sertad1), also known as p34(SEI‐1) or Trip‐Br1, is located within the amplified region of chromosome 19q13.1–13.2 and belongs to the Sertad family of proteins composed of four members, namely Sertad1‐4 . This family of proteins plays a role in gene transcriptional regulation, cell cycle progression and cancer pathogenesis . Sertad1 has been reported as a transcriptional regulator, cell cycle regulator, senescence inhibitor and apoptosis inhibitor .…”

“…10 This family of proteins plays a role in gene transcriptional regulation, cell cycle progression and cancer pathogenesis. 11,12 Sertad1 has been reported as a transcriptional regulator, cell cycle regulator, senescence inhibitor and apoptosis inhibitor. [13][14][15][16][17][18][19][20] Based on the Cancer Genome Atlas (TCGA) dataset from National Cancer Institute and the National Human Genome Research Institute, Sertad1 mRNA is overexpressed in clinical prostate cancer, similar to that in breast cancer (Supporting Information Fig.…”

Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance

“…TRIP-Br2 (also known as SERTAD2-SERTA domain containing 2) 12 , is a member of a novel family of mammalian transcriptional co-regulators comprised of five members 13 , four of which have been shown to modulate E2F-dependent transcriptional activities 12,14,15 . While the role of TRIP-Br2 in adipose tissue is virtually unknown, it has been proposed to recruit PHD zinc finger- and/or bromodomain-containing transcriptional co-regulators 12,16 , such as p300/CBP 17 and KRIP-1 18 , to E2F1/DP1 transcription complexes assembled on E2F-responsive promoters.…”

Gene expression profile, pathways, and transcriptional system regulation in indolent systemic mastocytosis

“…Leucine‐rich repeat interacting protein ( LRRFIP1 ) contributes to the pathology of myelodysplastic syndrome (23) and glioblastoma (24). Multiple tumours including lymphomas and solid tumours are related to overexpression of SERTAD2 (serta domain containing) (25). RAB27A gene product is a protein member of the ras oncogene family involved in neutrophil secretion (26) and melanocyte shape (27).…”