Triosephosphate Isomerase and Its Product Glyceraldehyde-3-Phosphate Are Involved in the Regulatory Mechanism That Suppresses Exit from the Quiescent State in Yeast Cells

Abstract

Our results suggest that, in quiescent cells, nutrient signals do not merely provoke a positive regulatory process to commence mitotic growth. Exit from the quiescent state in yeast cells is regulated by balancing between the positive and negative signaling pathways.

Antifungal Peptide P852 Effectively Controls Fusarium oxysporum, a Wilt-Causing Fungus, by Affecting the Glucose Metabolism and Amino Acid Metabolism as well as Damaging Mitochondrial Function

“…TIM and its product 3-phosphoglyceraldehyde have been shown to regulate spore germination in a negative feedback manner. 24 In addition to its involvement in the formation of high-energy phosphate bonds, GAPDH has been implicated in cell death and the regulation of gene expression. 25 Zhao et al revealed that wine yeast modulated the complex energy metabolism of Fusarium graminearum, and the expression levels of GAPDH and related genes involved in the TCA cycle were significantly reduced.…”

“…The radii of triosephosphate isomerase (TIM) and GAPDH reached 0.9768 and 0.9536, respectively. TIM and its product 3-phosphoglyceraldehyde have been shown to regulate spore germination in a negative feedback manner . In addition to its involvement in the formation of high-energy phosphate bonds, GAPDH has been implicated in cell death and the regulation of gene expression .…”