TRIMming down tumor suppressors in breast cancer

Bhatnagar, Sanchita; Green, Michael R.

doi:10.1080/15384101.2015.1024584

Cited by 7 publications

(4 citation statements)

References 8 publications

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“…The TRIM family of proteins may have an important role in tumor regulation ( 15 ), although the role of the TRIM protein family in breast cancer drug resistance has yet to be fully established. Using the Starbase and TargetScan databases, it was shown that only TRIM37 of the TRIM family of proteins was predicted to be a potential target of miR-1179 ( Fig.…”

Section: Resultsmentioning

confidence: 99%

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Long non‑coding RNA TMPO‑AS1 facilitates chemoresistance and invasion in breast cancer by modulating the miR‑1179/TRIM37 axis

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Zhao

et al. 2021

Oncol Lett

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Section: Resultsmentioning

confidence: 99%

“…However, the function and mechanism of TMPO-AS1 in DOC resistance and invasion in breast cancer cells has yet to be fully elucidated. In addition, tripartite motif-containing protein 37 (TRIM37) has been shown to be involved in the development of breast cancer ( 15 ), but the role of TRIM37 in breast cancer chemotherapy is unclear.…”

Section: Introductionmentioning

confidence: 99%

Long non‑coding RNA TMPO‑AS1 facilitates chemoresistance and invasion in breast cancer by modulating the miR‑1179/TRIM37 axis

Ning

Zhao

et al. 2021

Oncol Lett

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“…We have originally described tripartite motif-containing protein 37 (TRIM37) as a breast cancer oncoprotein that can epigenetically silence tumor suppressors (9,10). Clinically, high-TRIM37 associate with poor overall survival (9).…”

Section: Introductionmentioning

confidence: 99%

Oncogenic TRIM37 Links Chemoresistance and Metastatic Fate in Triple-Negative Breast Cancer

et al. 2020

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The majority of clinical deaths in patients with triple-negative breast cancer (TNBC) are due to chemoresistance and aggressive metastases, with high prevalence in younger women of African ethnicity. Although tumorigenic drivers are numerous and varied, the drivers of metastatic transition remain largely unknown. Here, we uncovered a molecular dependence of TNBC tumors on the TRIM37 network, which enables tumor cells to resist chemotherapeutic as well as metastatic stress. TRIM37-directed histone H2A monoubiquitination enforces changes in DNA repair that rendered TP53-mutant TNBC cells resistant to chemotherapy. Chemotherapeutic drugs triggered a positive feedback loop via ATM/E2F1/ STAT signaling, amplifying the TRIM37 network in chemoresistant cancer cells. High expression of TRIM37 induced transcriptomic changes characteristic of a metastatic phenotype, and inhibition of TRIM37 substantially reduced the in vivo propensity of TNBC cells. Selective delivery of TRIM37-specific antisense oligonucleotides using antifolate receptor 1-conjugated nanoparticles in combination with chemotherapy suppressed lung metastasis in spontaneous metastatic murine models. Collectively, these findings establish TRIM37 as a clinically relevant target with opportunities for therapeutic intervention.Significance: TRIM37 drives aggressive TNBC biology by promoting resistance to chemotherapy and inducing a prometastatic transcriptional program; inhibition of TRIM37 increases chemotherapy efficacy and reduces metastasis risk in patients with TNBC.

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“…12 Several studies indicated that TRIM37 plays a critical role in development and progression of tumors. [13][14][15] One study reported that the expression of TRIM37 was up-regulated in human breast cancer cell lines, and knockdown of TRIM37 substantially decreases tumor growth in mouse xenogras in human breast cancer cells. 16 However, its role in NSCLC is still unclear.…”

Section: Introductionmentioning

confidence: 99%

Silencing TRIM37 inhibits the proliferation and migration of non-small cell lung cancer cells

et al. 2018

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TRIMming down tumor suppressors in breast cancer

Cited by 7 publications

References 8 publications

Long non‑coding RNA TMPO‑AS1 facilitates chemoresistance and invasion in breast cancer by modulating the miR‑1179/TRIM37 axis

Long non‑coding RNA TMPO‑AS1 facilitates chemoresistance and invasion in breast cancer by modulating the miR‑1179/TRIM37 axis

Oncogenic TRIM37 Links Chemoresistance and Metastatic Fate in Triple-Negative Breast Cancer

Silencing TRIM37 inhibits the proliferation and migration of non-small cell lung cancer cells

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