Trimethylamine N-oxide / SREBP2 pathway is involved in sleep deprivation-induced cognitive dysfunction through regulating astrocytic cholesterol metabolism
Shan Zhu,
Yue Wang,
Yansong Li
et al.
Abstract:Sleep deprivation (SD) contributes to cognitive impairment. Astrocytic cholesterol biosynthesis is crucial for brain cholesterol homeostasis and cognitive function. However, the underlying mechanism of astrocytic cholesterol metabolism in SD-induced cognitive impairment has not been fully explored. Trimethylamine N-oxide (TMAO), a product of liver flavin-containing monooxygenase-3 (FMO3), has been shown to be increased in the urine of sleep-deprived humans and implicated with peripheral cholesterol metabolism.… Show more
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