Trimethylamine N‐oxide (TMAO) doubly locks the hydrophobic core and surfaces of protein against desiccation stress
Geying Ru,
Xiaoli Liu,
Yuwei Ge
et al.
Abstract:Interactions between proteins and osmolytes are ubiquitous within cells, assisting in response to environmental stresses. However, our understanding of protein–osmolyte interactions underlying desiccation tolerance is limited. Here, we employ solid‐state NMR (ssNMR) to derive information about protein conformation and site‐specific interactions between the model protein, SH3, and the osmolyte trimethylamine N‐oxide (TMAO). The data show that SH3–TMAO interactions maintain key structured regions during desiccat… Show more
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