Trimethylamine Adsorption Mechanism on Activated Carbon and Removal in Water and Oyster Proteolytic Solution

Chen, Deke; Wan, Peng; Cai, Bingna; Ye, Ziqing; Chen, Hua; Chen, Xin; Sun, Han‐Dong; Pan, Jianyu

doi:10.1007/s11802-021-4813-1

Cited by 3 publications

(1 citation statement)

References 40 publications

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“…In multiple animal experiments and clinical studies, it was shown that AC administered orally contributes to the amelioration of the gut microbiota composition affected in different pathological states [19,29,86,87]. This can be explained by broad-range adsorption by AC of some parts of gut-derived PAMPs and DAMPs such as microbe-associated molecular patterns, including bacteria [33,160], fecal cytokines [30], ammonia [30,45], endotoxin [33], and also the products from the interaction of the microbiota with the dietary substances such as acetaldehyde [161], trimethylamine [162], ethanol [163], and free fatty acids [164].…”

Section: Microbiomementioning

confidence: 99%

Activated Carbon for Sepsis Prevention and Intervention: A Modern Way of Utilizing Old Therapies

Snezhkova

Redl

Grillari

et al. 2023

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(1) Background: Uncontrolled inflammation often contributes to life-threatening sepsis sequela such as multi-organ dysfunction syndrome (MODS), and is accompanied by abnormal levels of pathological and damage-associated molecular patterns (PAMPs & DAMPs) in biological fluids. Activated carbon or charcoal (AC) of new generation with ameliorated biocompatibility has spurred renewed interest in the regulation of these toxins’ levels in inflammation states. (2) Methods: We searched PubMed, Google Scholar, ScienceDirect, Researchgate, and other sources for the relevant literature from 1550 B.C. till 2022 A.C. (3) Results: Laboratory and clinical investigations demonstrate that activated carbon or charcoal (AC) mitigates inflammation in different pathological states when applied orally, per rectum, or in a hemoperfusion system. AC protects the microbiome and bone marrow, acts as an anti-inflammatory and anti-oxidant remedy, and recovers the plasmatic albumin structure. The mechanism of AC action is related to a non-selective (broad-range) or/and selective adsorption of PAMPs & DAMPs from biological fluids. A high-adsorptive capacity towards noxious substances and application of AC as early as possible seems paramount in inflammation treatment for preventing sepsis and/or multi-organ failure. (4) Conclusion: AC could be considered an adjunctive treatment for preventing sepsis and/or multi-organ failure.

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