Trimethoprim‐sulfamethoxazole‐induced drug reaction with eosinophilia and systemic symptoms in a child with congenital renal disease

Maarouf, Melody; Wickenheiser, Marilyn; Krase, Jeffrey M.; Wolter, Sierra; Shi, Vivian Y.

doi:10.1111/pde.13607

Cited by 8 publications

(9 citation statements)

References 6 publications

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“…Newell et al found phenytoin, carbamazepine, and phenobarbital to be the most common culprits, while other pediatric DRESS series confirmed lamotrigine and phenytoin, respectively, as the most common etiologies . In the pediatric literature, antibiotics are being increasingly reported as the primary etiology with vancomycin, amoxicillin‐clavulanic acid, and trimethoprim‐sulfamethoxazole most commonly reported …”

Section: Discussionmentioning

confidence: 99%

“…6,9,34 In the pediatric literature, antibiotics are being increasingly reported as the primary etiology with vancomycin, amoxicillin-clavulanic acid, and trimethoprim-sulfamethoxazole most commonly reported. [6][7][8][9][12][13][14][15][16][17][18][19]21 Patients developed symptoms and presented to physicians at 4 and 5 weeks, respectively, after the inciting medication. Previous series reported an earlier onset of antibiotic-induced pediatric DRESS with an average time to symptoms of approximately 6-11 days after antibiotic therapy.…”

Section: Discussionmentioning

confidence: 99%

“…Understanding of DRESS in children is based upon case reports and small case series. The most commonly implicated drugs in children include antibiotics, namely trimethoprim‐sulfamethoxazole and vancomycin, followed by antiepileptic medications, such as lamotrigine, carbamazepine, and phenytoin . Ibuprofen, nevirapine, raltegravir, acetylsalicylic acid, griseofulvin, fluoxetine, and sulthiamine have been associated triggers in single pediatric case reports .…”

Section: Introductionmentioning

confidence: 99%

“…The most commonly implicated drugs in children include antibiotics, namely trimethoprim-sulfamethoxazole and vancomycin, followed by antiepileptic medications, such as lamotrigine, carbamazepine, and phenytoin. [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] Ibuprofen, nevirapine, raltegravir, acetylsalicylic acid, griseofulvin, fluoxetine, and sulthiamine have been associated triggers in single pediatric case reports. 3,[26][27][28][29][30][31] In addition, Sasidharanpillai et al found DRESS to occur more promptly after antibiotic therapy, averaging about one week after drug initiation, compared to over three weeks after antiepileptic therapy.…”

Section: Introductionmentioning

confidence: 99%

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Drug reaction with eosinophilia and systemic symptoms: Pediatric case series and literature review

Oberlin

Rahnama‐Moghadam

Alomari

et al. 2019

Pediatric Dermatology

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Background Pediatric Drug reaction with eosinophilia and systemic symptoms (DRESS) is an uncommon disease that can be difficult to diagnose. This case series and literature review highlights the clinical features of pediatric DRESS and underscores the differential diagnoses, culprit medications, and need for clinical follow‐up to detect associated autoimmune sequelae. Objective To describe the clinical and laboratory features of pediatric DRESS, identify associated culprit medications, and discuss the natural history of disease. Methods Ten cases of pediatric DRESS were identified in the electronic medical record by searching the inpatient dermatology consultation list at Indiana University between 2013 and 2018. Clinical and laboratory data were collected including demographics, differential diagnoses, culprit medications, resolution of disease, and autoimmune sequelae. Results Pediatric patients with DRESS presented at a mean age of 11.5 years and demonstrated a mean time from drug initiation to onset of symptoms of 4 weeks. The most common inciting drugs included antibiotics (62.5%) followed by antiepileptics (37.5%). Rash and transaminitis resolved by 3 weeks, and 20% of patients, all female, developed autoimmune sequelae including Hashimoto's thyroiditis and an undifferentiated connective tissue disorder and occurred at an average of 14.5 weeks after diagnosis. Limitations This was a small retrospective study of an uncommon clinical diagnosis at a single institution. Conclusions Pediatric DRESS was most commonly caused by antibiotics which are being increasingly recognized in the literature as the predominant culprit medications. The development of autoimmune sequelae is a notable consequence that can present weeks after illness and may preferentially affect female patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Drug reaction with eosinophilia and systemic symptoms: Pediatric case series and literature review

Oberlin

Rahnama‐Moghadam

Alomari

et al. 2019

Pediatric Dermatology

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“…Fifteen case reports, six case series, and four retrospective cohort studies, published between 1984 and 2022, with a total of 140 patients, from preterm newborn neonates to adolescents, were included (Table 1) . Most of the studies were conducted in infants (n = 6) [20][21][22][23][24][25][26] and children (n = 13) [27][28][29][30][31][32][33][34][35][36][37][38][39]. In addition, one study reported findings from either preterm newborn neonates [18] or term or postterm neonates [19], and four studies included adolescents [36,38,40,41] (of note, Novelli et al [36] and Scheffner et al [38] reported findings from both children and adolescents).…”

Section: Literature Search and Study Characteristicsmentioning

confidence: 99%

Therapeutic Management of Idiosyncratic Drug-Induced Liver Injury and Acetaminophen Hepatotoxicity in the Paediatric Population: A Systematic Review

et al. 2022

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Introduction Drug-induced liver injury (DILI) is a rare but serious adverse event that can progress to acute liver failure (ALF). The evidence for treatment of DILI in children is scarce. Objective We aimed to comprehensively review the available literature on the therapies for both acetaminophen overdose (APAP) and idiosyncratic DILI in the paediatric population. Methods We included original articles conducted in a paediatric population (< 18 years) in which a therapeutic intervention was described to manage APAP or idiosyncratic DILI. Findings were summarized based on age groups (preterm newborn neonates, term and post-term neonates, infants, children and adolescents). Results Overall, 25 publications (fifteen case reports, six case series and four retrospective cohort studies) were included, including a total of 140 paediatric DILI cases, from preterm newborn neonates to adolescents. N-acetylcysteine was used to treat 19 APAP cases. N-acetylcysteine (n = 14), ursodeoxycholic acid (n = 3), corticosteroids (n = 31), carnitine (n = 16) and the combination of glycyrrhizin, reduced glutathione, polyene phosphatidylcholine and S-adenosylmethionine (n = 31) were the therapeutic options for treating idiosyncratic DILI. The molecular adsorbent recirculating system was used in the management of either APAP (n = 4) or idiosyncratic DILI (n = 2), while 20 paediatric ALF cases received continuous renal replacement therapy. Conclusions This systematic review identified DILI in the paediatric population who have received specific treatment. These interventions appear to be mainly extrapolated from low-quality evidence from the adult population. Thus, there is a need for high-quality studies to test the efficacy of known and novel therapies to treat DILI specifically addressed to the paediatric population. PROSPERO registration number CRD42021214702.

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Dosing Recommendations for Pediatric Patients With Renal Impairment

Al-khouja

Park

Anderson

et al. 2020

The Journal of Clinical Pharma

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A treatment gap exists for pediatric patients with renal impairment. Alterations in renal clearance and metabolism of drugs render standard dosage regimens inappropriate and may lead to drug toxicity, but these studies are not routinely conducted during drug development. The objective of this study was to examine the clinical evidence behind current renal impairment dosage recommendations for pediatric patients in a standard pediatric dosing handbook. The sources of recommendations and comparisons included the pediatric dosing handbook (Lexicomp), the U.S. Food and Drug Administration-approved manufacturer's labels, and published studies in the literature. One hundred twenty-six drugs in Lexicomp had pediatric renal dosing recommendations. Only 14% (18 of 126) of Lexicomp pediatric renal dosing recommendations referenced a pediatric clinical study, and 15% of manufacturer's labels (19 of 126) described specific dosing regimens for renally impaired pediatric patients. Forty-two products had published information on pediatric renal dosing, but 19 (45%) were case studies. When pediatric clinical studies were not referenced in Lexicomp, the renal dosing recommendations followed the adult and pediatric dosing recommendations on the manufacturer's label. Clinical evidence in pediatric patients does not exist for most renal dosing recommendations in a widely used pediatric dosing handbook, and the adult renal dosing recommendations from the manufacturer's label are currently the primary source of pediatric renal dosing information.

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Trimethoprim‐sulfamethoxazole‐induced drug reaction with eosinophilia and systemic symptoms in a child with congenital renal disease

Cited by 8 publications

References 6 publications

Drug reaction with eosinophilia and systemic symptoms: Pediatric case series and literature review

Drug reaction with eosinophilia and systemic symptoms: Pediatric case series and literature review

Therapeutic Management of Idiosyncratic Drug-Induced Liver Injury and Acetaminophen Hepatotoxicity in the Paediatric Population: A Systematic Review

Dosing Recommendations for Pediatric Patients With Renal Impairment

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