Trimethoprim–Sulfamethoxazole Compared with Ciprofloxacin for Treatment and Prophylaxis of <i>Isospora belli</i> and <i>Cyclospora cayetanensis</i> Infection in HIV-Infected Patients

Verdier, Rose-Irene; Fitzgerald, Daniel W.; Johnson, Warren D.; Pape, Jean William

doi:10.7326/0003-4819-132-11-200006060-00006

Cited by 222 publications

(106 citation statements)

References 14 publications

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“…Maintenance therapy with either trimethoprim-sulfamethoxazole or sulfadoxine-pyrimethamine is required to prevent recurrent disease (275). Alternatives include nitazoxanide (a new thiazolide antiparasitic agent), combination therapy with both pyrimethamine and leucovorin, or ciprofloxacin (295).…”

Section: Cyclosporamentioning

confidence: 99%

Clinical Significance of Enteric Protozoa in the Immunosuppressed Human Population

et al. 2009

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SUMMARY Globally, the number of immunosuppressed people increases each year, with the human immunodeficiency virus (HIV) pandemic continuing to spread unabated in many parts of the world. Immunosuppression may also occur in malnourished persons, patients undergoing chemotherapy for malignancy, and those receiving immunosuppressive therapy. Components of the immune system can be functionally or genetically abnormal as a result of acquired (e.g., caused by HIV infection, lymphoma, or high-dose steroids or other immunosuppressive medications) or congenital illnesses, with more than 120 congenital immunodeficiencies described to date that either affect humoral immunity or compromise T-cell function. All individuals affected by immunosuppression are at risk of infection by opportunistic parasites (such as the microsporidia) as well as those more commonly associated with gastrointestinal disease (such as Giardia). The outcome of infection by enteric protozoan parasites is dependent on absolute CD4+ cell counts, with lower counts being associated with more severe disease, more atypical disease, and a greater risk of disseminated disease. This review summarizes our current state of knowledge on the significance of enteric parasitic protozoa as a cause of disease in immunosuppressed persons and also provides guidance on recent advances in diagnosis and therapy for the control of these important parasites.

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Section: Cyclosporamentioning

confidence: 99%

Clinical Significance of Enteric Protozoa in the Immunosuppressed Human Population

et al. 2009

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“…10,11 In our case, we decided to use ciprofloxacin as therapy of both infections, because it is widely reported the high percentage of resistance to TMP-SMX in S. typhi strains. 3 In the present case, diarrhoea ceased after the first week of therapy, but the patient did not provide a further fecal sample to evaluate the success of the treatment.…”

Section: Discussionmentioning

confidence: 99%

Co-infection withCyclospora cayetanensisandSalmonella typhiin a patient with HIV infection and chronic diarrhoea

Llanes

Velázquez

Reyes

et al. 2013

Pathogens and Global Health

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A 45-year-old-Haitian male patient with fever, abdominal cramping, chronic diarrhoea and weight loss of about 3 kg was investigated. Stool examination revealed Salmonella typhi and Cyclospora cayetanensis. The HIV test was positive with a CD4 count of 130 cells/mm 3 . We provided the first report of co-infection Cyclospora cayetanensis and Salmonella typhi in a HIV patient with chronic diarrhoea. The patient was treated with oral ciprofloxacin, 500 mg, twice daily for two weeks, with a good clinical outcome.

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“…En este sentido, el inicio temprano del tratamiento anti-retroviral evitaría el agotamiento de LT CD4+ y mantendría el fenotipo Th17 intestinal, permitiendo la restauración inmunológica intestinal y consecuente mejoría clínica 15,16 . El medicamento de elección para el tratamiento y profilaxis de la infección por C. belli es cotrimoxazol forte (160 mg de trimetoprim y 800 mg de sulfametoxazol), pero varía de acuerdo al estado de inmunocompromiso 7,17 . Sin embargo, también se ha descrito el uso de ciprofloxacina y nitazoxanida 10,11,17 .…”

Section: Artículo Originalunclassified

“…El medicamento de elección para el tratamiento y profilaxis de la infección por C. belli es cotrimoxazol forte (160 mg de trimetoprim y 800 mg de sulfametoxazol), pero varía de acuerdo al estado de inmunocompromiso 7,17 . Sin embargo, también se ha descrito el uso de ciprofloxacina y nitazoxanida 10,11,17 . El control de la infección por C. belli, así como de otras infecciones oportunistas, requerirá probablemente de una nueva generación de fármacos específicos o el mejor uso de los mismos, así como el manejo integral del paciente.…”

Section: Artículo Originalunclassified

Infección por Cystoisospora belli en pacientes con VIH: análisis de casos con diferente evolución clínica

Silva-Díaz

Fernández-Valverde

Hernández-Córdova

et al. 2017

Rev. chil. infectol.

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Trimethoprim–Sulfamethoxazole Compared with Ciprofloxacin for Treatment and Prophylaxis of Isospora belli and Cyclospora cayetanensis Infection in HIV-Infected Patients

Abstract: A 1-week course of trimethoprim-sulfamethoxazole is effective in HIV-infected patients with cyclosporiasis or isosporiasis. Although ciprofloxacin is not as effective, it is acceptable for patients who cannot tolerate trimethoprim-sulfamethoxazole.

Cited by 222 publications

References 14 publications

Clinical Significance of Enteric Protozoa in the Immunosuppressed Human Population

Clinical Significance of Enteric Protozoa in the Immunosuppressed Human Population

Co-infection withCyclospora cayetanensisandSalmonella typhiin a patient with HIV infection and chronic diarrhoea

Infección por Cystoisospora belli en pacientes con VIH: análisis de casos con diferente evolución clínica

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