Trimethoprim-sulfamethoxazole-associated aseptic meningitis: Case reports and review of the literature

Trimethoprim-Sulfamethoxazole-Induced Aseptic Meningitis: A Rare Presentation of Commonly Used Antibiotic

“…A recent review by Bruner et al [9] revealed 41 cases of TSIAM in the literature. The mechanism of the reaction was not fully understood; however, a possible mechanism was thought to be related to type II hypersensitivity reaction with immune complex deposition as this was noted in the serum of three patients in addition to the faster subsequent reaction following a reexposure TMP/SMX [10, 11]. Another plausible mechanism is related to type IV hypersensitivity with a concept of pharmacologic interaction of the drugs with immune receptors.…”

One-pot synthesis of pyrimidines under solvent-free conditions

“…All commercially available chemicals were obtained from Merck and Fluka companies, and used without further purification unless otherwise stated. Nuclear magnetic resonance 1 H and 13 C NMR spectra (Sharif University and Urmia University) were recorded on Bruker Avance 300 and 500 MHz FT NMR spectrometers. Infrared (IR) spectroscopy was conducted on a Perki-nElmer GX FT-IR spectrometer.…”

“…1) [9][10][11][12]. Several examples of pharmaceutically important compounds include trimethoprim [13] and Gleevec (imatinib mesylate) [14]. Natural and unnatural polymers also contain pyrimidine derivatives [15][16][17].…”

Catalytic effect of nano copper ferrite on the synthesis of 6-(anthracen-9-yl)-4-(benzofuran-2-yl)pyrimidin-2-(1H)-one

“…Pyrimidine derivatives are extremely useful as natural products, pharmaceuticals and functional materials [11,12]. Several pharmaceutical essential compounds such as trimethoprim, sulfadiazine, Gleevec and vitamin B1 are the different form of pyrimidines [13][14][15]. Pyrimidine moiety present in barbituric acid and its derivatives are employed as hypnotics [16].…”