Trimetazidine protects against myocardial ischemia/reperfusion injury by inhibiting excessive autophagy

Abstract

TMZ improved cardiac function, alleviated myocardial injury and oxidative stress, and reduced the myocardial infarct area and apoptosis. TMZ inhibited MI/R-induced myocardial autophagy, H/R-induced H9c2 cell apoptosis, and autophagy flux. The effect of TMZ on autophagy was repressed by LY294002. TMZ protected against MI/R injury by inhibiting excessive autophagy via activating the AKT/mTOR pathway.

Tranilast Treatment Attenuates Cerebral Ischemia‐Reperfusion Injury in Rats Through the Inhibition of Inflammatory Responses Mediated by NF‐κB and PPARs

“…Ischemia-reperfusion injury (IRI) is serious tissue damage arising from the restoration of the blood supply after ischemia. 1 The lack of oxygen, adenosine triphosphate, and nutrients from the blood leads to functional and metabolic disorders of the organs. As a consequence, restoration of the blood flow results in the oxidative damage and inflammation rather than recovery.…”

Biphasic effects of autophagy on decompression bubble‐induced endothelial injury

“…28 However, under pathological conditions, impaired or over-activated autophagy promotes cell injuries by accumulating intracellular damaged components, inducing excessive oxidative stress and promoting apoptosis death. 29 In present study, there was a close relationship between LC3-II/I ratio and endothelial injury, indicating that autophagy was involved in bubble-induced endothelial dysfunction. The results of pre-treatment with autophagy inhibitor 3-MA showed that it inhibited the increase of LC3-II/I ratio and significantly alleviated endothelial injury caused by microbubble contacts for 10, 20 and 30 minutes, confirming that autophagy promoted endothelial injury under these microbubble contact periods.…”

“…As a basal cellular process response to many stressors, autophagy may represent a cell protection mechanism to guarantee an efficient cytosolic clearance and maintain bioenergetics homoeostasis . However, under pathological conditions, impaired or over‐activated autophagy promotes cell injuries by accumulating intracellular damaged components, inducing excessive oxidative stress and promoting apoptosis death . In present study, there was a close relationship between LC3‐II/I ratio and endothelial injury, indicating that autophagy was involved in bubble‐induced endothelial dysfunction.…”

Qishentaohong Granule as Adjuvant Therapy for Improving Cardiac Function and Quality of Life in Patients with Chronic Heart Failure: a Randomized Controlled Trial

“…Patients who met any of the following criteria were excluded from this trial: (1) acute myocardial infarction, cardiogenic shock, lethal cardiac arrhythmias, cardiac tamponade, pulmonary embolism, acute myocardial infarction, and other severe conditions; (2) serious primary diseases of lung, liver, kidney, endocrine system, or hematological system; (3) pregnancy or lactation; (4) allergic constitution or allergy to multiple drugs; (5) patients with mental illness, mental disorders, dementia or malignant tumor; (6) participants who have taken Chinese medicine (including proprietary Chinese medicines) or participated in other clinical trials in the past 2 weeks; and (7) patients who had incomplete clinical data.…”

“…Previous studies have found that Chinese herbal medicine with qi-invigorating effect can signi cantly improve the myocardial energy substances ATP and PCr in rats with heart failure [5]. TMZ, which are known to regulate myocardial energy metabolism, are commonly used in the treatment of heart failure to optimize energy metabolism substrates and promote glucose metabolism [6].…”