Trimester specific reference intervals for thyroid function tests in normal Indian pregnant women

Sekhri, Tarun; Juhi, Juhi Agarwal; Wilfred, R; Kanwar, Ratnesh; Sethi, Jyoti; Bhadra, Kuntal; Nair, Sirimavo; Singh, Simar Rajan

doi:10.4103/2230-8210.172239

Cited by 22 publications

(22 citation statements)

References 32 publications

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“…negative TPOAb was similar to their values in the cross-sectional study (0.2 mIU/l vs. 0.19 mIU/l for cross sectional and 0.02 mIU/l for longitudinal studies), while the 97.5th percentile of TSH concentration in our study was higher than their similar percentile in both longitudinal and cross sectional studies (4.60 mIU/l vs. 3.54 mIU/l for cross sectional and 3.65 mIU/l for longitudinal studies). Previous studies reported the 2.5th and 97.5th percentiles of TSH in Brazilian [21], Swiss [22] and Indian [23] pregnant women during the first trimester as 0.14-3.68 mIU/l, 0.0878-2.829 mIU/l, 0.09-6.65 mIU/l, respectively. Another study [24] defined the 2.5th and 97.5th percentiles of TSH in pregnant women with negative TPOAb at 4-13 weeks of gestation at 0.06-8.3 mIU/l, 0.04-9.3 mIU/l, and 0.12-7.4 mIU/l in United Arab Emirates, other Arab nations, and Asians, respectively.…”

Section: Discussionmentioning

confidence: 99%

Reference Intervals for Thyroid Hormones During the First Trimester of Gestation: A Report from an Area with a Sufficient Iodine Level

et al. 2019

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The physiological changes during pregnancy modulate the endocrine system. Therefore, both the American and the European thyroid associations recommend the use of local trimester-specific reference intervals. The purpose of this study was to establish the first trimester reference intervals for thyroid function tests in the central area of Iran. We examined 436 pregnant women in their first trimester of pregnancy, and 444 non-pregnant women in a cross sectional study. Serum levels of thyroid stimulating hormone (TSH), free thyroxin (FT4), free triiodothyronine (FT3), thyroid peroxidase antibody, urinary iodine concentration (UIC), and thyroid volume were measured for all subjects. The first trimester-specific reference intervals (2.5th–97.5th percentile) were determined for 185 pregnant women and 256 non-pregnant women with negative TPOAb, adequate iodine level (UIC≥150 μg/l in pregnant and UIC≥100 μg/l in non-pregnant women), and normal thyroid examination. We calculated multiples of the median (MoM) for TFTs to normalize the obtained data. The first trimester-specific reference intervals of serum TSH, FT4, and FT3 for pregnant women were 0.20–4.60 mIU/l, 9.0–18.02 pmol/l, and 3.40–5.64 pmol/l, respectively, while the corresponding figures for non-pregnant women were 0.59–5.60 mIU/l, 9.52–19.30 pmol/l, and 3.70–5.55 pmol/l, respectively. The first and 99th percentile MoM of TSH in pregnant women in their first-trimester was 0.06–4.62. The local normal reference ranges for the first trimester of pregnancy in central region of Iran were different from the ranges suggested by the ATA.

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Section: Discussionmentioning

confidence: 99%

Reference Intervals for Thyroid Hormones During the First Trimester of Gestation: A Report from an Area with a Sufficient Iodine Level

et al. 2019

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“…17,18 These studies reported wide variation in parameter ranges due to discrepancies in assay methods, ethnicity of study population along with variations in socioeconomic and nutritional status, reference population selection, and sample size determination criteria. 19,20 The strength of our study is that it is based on the population temporarily migrated to Ranchi for professional purposes and which has a pan-Indian profile because of a multicultural, multiethnic, and demographic distribution.…”

Section: Discussionmentioning

confidence: 99%

Specific Reference Intervals of Serum Triiodothyronine, Thyroxine, and Thyroid-stimulating Hormone in Normal Pregnant Indian Women as per Trimester

Hazra¹,

Mitra²,

Pal³

2017

Indian Journal of Medical Biochemistry

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Aim Maternal thyroid hormone levels during pregnancy are vital for the health of the mother as well as the developing child. Fetal growth is affected by maternal thyroid levels. Various physiological changes like alterations of thyroxine-binding globulins, human chorionic gonadotropin level, and changes in iodide metabolism affect maternal thyroid hormone levels. Therefore, reference intervals (RIs) for thyroid hormones in pregnant population require to be established separately from the general population. Materials and methods The RIs of serum triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) were determined in healthy pregnant women by enzyme-linked immunosorbent assay (ELISA) technique after segregating them into three trimesters. This study was conducted in a 492-bedded zonal-level hospital. The reference population was chosen from a study population of pregnant women by strict inclusion and exclusion criteria. The assays were done by the most-commonly used, economical ELISA method employing standard kits. Tests were done using accurate and precise methods with proper quality control measures. Results The RIs were calculated from the central 95% of distribution of total T3, total T4, and TSH values located between 2.5 and 97.5 percentile values. The 0.90 confidence intervals for the upper and lower reference limits were calculated. The values thus obtained were different from those provided by the manufacturer kit literature. Conclusion It is recommended to determine one's own laboratory-specific, method-specific, trimester-wise RIs for maternal thyroid hormone status and use them for screening of pregnant women. How to cite this article Chakrabarty BK, Mitra B, Pal R, Hazra N. Specific Reference Intervals of Serum Triiodothyronine, Thyroxine, and Thyroid-stimulating Hormone in Normal Pregnant Indian Women as per Trimester. Indian J Med Biochem 2017;21(1):17-21.

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“…17,18 These studies reported wide variation in parameter ranges due to discrepancies in assay methods, ethnicity of study population along with variations in socioeconomic and nutritional status, reference population selection, and sample size determination criteria. 19,20 The strength of our study is that it is based on the population temporarily migrated to Ranchi for professional purpose and which is having pan Indian profile because of multicultural and multiethnicity and demographic distribution.…”

Section: Discussionmentioning

confidence: 99%

Specific Reference Intervals of Serum Triiodothyronine, Thyroxine, and Thyroid-stimulating Hormone in Normal Pregnant Indian Women as per Trimester

Hazra¹,

Mitra²,

Pal³

2017

Indian Journal of Medical Biochemistry

View full text Add to dashboard Cite

Aim Maternal thyroid hormone level during pregnancy is a vital parameter for the health of mother as well as developing child. Fetal growth is affected by maternal thyroid levels. Various physiological changes like alterations of thyroxine binding globulins (TBGs), beta-human chorionic gonadotropin (β-hCG) level, and change of iodide metabolism affect maternal thyroid hormone levels. Therefore, reference intervals (RI) for thyroid hormones in pregnant population require to be established separately from general population. Materials and methods The RIs of serum triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) were determined in healthy pregnant women by enzyme-linked immunosorbent assay (ELISA) technique after segregating them into three trimesters. This study was conducted in a 492-bedded zonal level hospital. The reference population was chosen from a study population of pregnant women by strict inclusion and exclusion criteria. The assays were done by the most commonly used economical ELISA method using standard kits. Tests were done using accurate and precise methods with proper quality control measures. Results The RIs were calculated from the central 95% of distribution of total T3, total T4, and TSH values located between 2.5 and 97.5 percentile values. The 0.90 confidence intervals (CIs) for the upper and lower reference limits were calculated. The values thus obtained were different from those provided by manufacturer kit literature. Conclusion It is recommended to determine own laboratory-specific, method-specific, trimester-wise RI for maternal thyroid hormone status and use them for screening of pregnant mothers. How to cite this article Chakrabarty BK, Mitra B, Pal R, Hazra N. Specific Reference Intervals of Serum Triiodothyronine, Thyroxine, and Thyroid-stimulating Hormone in Normal Pregnant Indian Women as per Trimester. Indian J Med Biochem 2017;21(2):96-100.

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Trimester specific reference intervals for thyroid function tests in normal Indian pregnant women

Cited by 22 publications

References 32 publications

Reference Intervals for Thyroid Hormones During the First Trimester of Gestation: A Report from an Area with a Sufficient Iodine Level

Reference Intervals for Thyroid Hormones During the First Trimester of Gestation: A Report from an Area with a Sufficient Iodine Level

Specific Reference Intervals of Serum Triiodothyronine, Thyroxine, and Thyroid-stimulating Hormone in Normal Pregnant Indian Women as per Trimester

Specific Reference Intervals of Serum Triiodothyronine, Thyroxine, and Thyroid-stimulating Hormone in Normal Pregnant Indian Women as per Trimester

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