Trimer-like microrobots with multimodal locomotion and reconfigurable capabilities

Yu, Shimin; Li, Tianlong; Ji, Fengtong; Zhao, Shuqi; Liu, Kai; Zhang, Z.; Zhang, W.; Mei, Yongfeng

doi:10.1016/j.mtadv.2022.100231

Cited by 35 publications

(27 citation statements)

References 57 publications

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“…For biomedical applications, the pH-sensitive materials or assemblies that are stable at physiological pH (pH = 7.4) and unstable at lower pH (pH = 5.0–7.2) [ 1 , 2 , 3 , 4 , 5 ], together with the efficient carriers of a different nature [ 6 , 7 , 8 , 9 , 10 ], are of great interest [ 1 , 2 , 3 , 4 , 5 ]. Particularly, for drug delivery applications in cancer treatment, these types of materials, if properly tuned, enable the release of therapeutics within tumor tissues (pH = 6.5–7.2) [ 11 , 12 , 13 , 14 , 15 , 16 , 17 ], making the pH sensibility an excellent strategy for targeted chemotherapeutics delivery.…”

Section: Introductionmentioning

confidence: 99%

Solid-Phase Synthesized Copolymers for the Assembly of pH-Sensitive Micelles Suitable for Drug Delivery Applications

Ghiarasim¹,

Tiron

et al. 2022

Nanomaterials

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Diblock copolymers of polyhistidine are known for their self-assembly into micelles and their pH-dependent disassembly due to the amphiphilic character of the copolymer and the unsaturated imidazole groups that undergo a hydrophobic-to-hydrophilic transition in an acidic pH. This property has been largely utilized for the design of drug delivery systems that target a tumor environment possessing a slightly lower extracellular pH (6.8–7.2). The main purpose of this study was to investigate the possibility of designed poly(ethylene glycol)-polyhistidine sequences synthesized using solid-phase peptide synthesis (SPPS), to self-assemble into micelles, to assess the ability of the corresponding micelles to be loaded with doxorubicin (DOX), and to investigate the drug release profile at pH values similar to a malignant extracellular environment. The designed and assembled free and DOX-loaded micelles were characterized from a physico-chemical point of view, their cytotoxicity was evaluated on a human breast cancer cell line (MDA-MB-231), while the cellular areas where micelles disassembled and released DOX were assessed using immunofluorescence. We concluded that the utilization of SPPS for the synthesis of the polyhistidine diblock copolymers yielded sequences that behaved similarly to the copolymeric sequences synthesized using ring-opening polymerization, while the advantages of SPPS may offer facile tuning of the histidine site or the attachment of a large variety of functional molecules.

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Section: Introductionmentioning

confidence: 99%

Solid-Phase Synthesized Copolymers for the Assembly of pH-Sensitive Micelles Suitable for Drug Delivery Applications

Ghiarasim¹,

Tiron

et al. 2022

Nanomaterials

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“…Helical microswimmers (Wang et al, 2018;Jeon et al, 2019;Liu et al, 2021;Dong et al, 2022) and surface microrobots have achieved precise navigation in micropores and microchannels under the remote propelling and steering triggered by external magnetic fields (Li et al, 2017;Xie et al, 2019). In particular, magnetically propelled surface microrobots are capable of autonomously circumventing 3D barriers and overcoming complex cracks, opening new possibilities for a wide range of applications at the nanoscale (Li et al, 2018;Yu et al, 2019;Feng et al, 2021;Yu et al, 2021;Yu et al, 2022). These studies indicate that magnetically controlled Janus micro-and nanorobots are suitable for specific work in aqueous media.…”

Section: Introductionmentioning

confidence: 94%

A Robot Platform for Highly Efficient Pollutant Purification

Wang

Liao

et al. 2022

Front. Bioeng. Biotechnol.

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In this study, we propose a highly efficient robot platform for pollutant adsorption. This robot system consists of a flapping-wing micro aircraft (FWMA) for long-distance transportation and delivery and cost-effective multifunctional Janus microrobots for pollutant purification. The flapping-wing micro air vehicle can hover for 11.3 km with a flapping frequency of approximately 15 Hz, fly forward up to 31.6 km/h, and drop microrobots to a targeted destination. The Janus microrobot, which is composed of a silica microsphere, nickel layer, and hydrophobic layer, is used to absorb the oil and process organic pollutants. These Janus microrobots can be propelled fast up to 9.6 body lengths per second, and on-demand speed regulation and remote navigation are manageable. These Janus microrobots can continuously carry oil droplets in aqueous environments under the control of a uniform rotating magnetic field. Because of the fluid dynamics induced by the Janus microrobots, a highly efficient removal of Rhodamine B is accomplished. This smart robot system may open a door for pollutant purification.

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“…Flexibility and controllability are crucial for nano/micromotors in achieve their applications. Yu et al [ 92 ] designed a magnetic trimer-like nano/micromotor composed of three magnetic Janus colloids with different diameters, manifesting actively controlled manipulation. It could pass through a complex simulated vascular channel.…”

Section: Nano/micromotors In Blood Vesselsmentioning

confidence: 99%

Applications of Nano/Micromotors for Treatment and Diagnosis in Biological Lumens

et al. 2022

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Natural biological lumens in the human body, such as blood vessels and the gastrointestinal tract, are important to the delivery of materials. Depending on the anatomic features of these biological lumens, the invention of nano/micromotors could automatically locomote targeted sites for disease treatment and diagnosis. These nano/micromotors are designed to utilize chemical, physical, or even hybrid power in self-propulsion or propulsion by external forces. In this review, the research progress of nano/micromotors is summarized with regard to treatment and diagnosis in different biological lumens. Challenges to the development of nano/micromotors more suitable for specific biological lumens are discussed, and the overlooked biological lumens are indicated for further studies.

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Trimer-like microrobots with multimodal locomotion and reconfigurable capabilities

Cited by 35 publications

References 57 publications

Solid-Phase Synthesized Copolymers for the Assembly of pH-Sensitive Micelles Suitable for Drug Delivery Applications

Solid-Phase Synthesized Copolymers for the Assembly of pH-Sensitive Micelles Suitable for Drug Delivery Applications

A Robot Platform for Highly Efficient Pollutant Purification

Applications of Nano/Micromotors for Treatment and Diagnosis in Biological Lumens

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