Trimeprazine Tartrate for Premedication of Children

Cope, R. W.; Glover, W.J.

doi:10.1016/s0140-6736(59)91939-7

Cited by 23 publications

(7 citation statements)

References 4 publications

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“…Trimeprazine tartrate (Vallergan) was introduced into clinical practice as an oral premedicant for children by Cope and Glover (1959) to induce a state "between sedation and basal narcosis". Its use is associated with salivary suppression, antiemesis, marked postoperative pallor and amnesia (Doughty, 1962).…”

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confidence: 99%

ORAL PREMEDICATION IN CHILDREN WITH TRIMEPRAZINE: The Effect of varying Dosage and Timing

Davies¹,

Doughty²

1966

British Journal of Anaesthesia

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In the belief that both dosage and timing of premedication may be important, a double blind trial was carried out on 484 children undergoing adenotonsillectomy receiving trimeprazine with hyoscine according to four differing methods within the limits suggested by the manufacturers' instructions. Thus trimeprazine was given in doses of 1 or 2 mg/lb. (2.2 or 4.4 mg/kg), 1 or 2 hours pre-operatively. The most intense action of the drug was evident when the stronger dose was given 2 hours before operation. However, this was associated with a comparative deterioration in behaviour of the children in the anaesthetic room and a higher frequency of undue postoperative pallor. Possible advantages of the more intense action of trimeprazine are salivary suppression and amnesia. Postoperative vomiting was infrequent with all four methods of premedication. A plea is made for the more critical evaluation of premedicant drugs.

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ORAL PREMEDICATION IN CHILDREN WITH TRIMEPRAZINE: The Effect of varying Dosage and Timing

Davies¹,

Doughty²

1966

British Journal of Anaesthesia

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“…In view of the comparatively good behaviour of children in the present trial receiving the control premedication, one may wonder whether trimeprazine, so far from improving behaviour, may in fact tend towards an adverse effect. Cope and Glover (1959) used trimeprazine, without hyoscine, given 1^ hours pre-operatively and induced anaesthesia by inhalation in contrast to the intravenous method used in the present trial. Venepuncture normally requires the co-operation of the patient while an inhalational induction may be more suited to one whose consciousness is clouded by the premedication.…”

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confidence: 99%

Oral Premedication in Children

Doughty

1962

British Journal of Anaesthesia

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In view of the current interest in the subject of oral premedication in children it seemed desirable to stage a blind controlled clinical trial of drugs recently recommended by various authors. Pecazine has been recommended by Corssen and Allen (1958) and by Green (1959); trimeprazine by Cope and Glover (1959) and by Gunner and Fox (1960); and methylpentynol by Rendell (1954), Gusterson (1955) and by Kelsall (1957). In this trial the drugs were ordered to be administered 1 hour before operation in accordance with the dosage given in table I. As a salivary suppressant, hyoscine hydrobromide was mixed with each of the sedative drugs and, to provide a control, a blank solution containing hyoscine-only was used. The effects of the four premedications were studied on 480 children aged 2 to 12 undergoing adenotonsillectomy or other minor nose and throat surgery. The premedications were allocated at random and the bottles containing the drug solutions were labelled with code letters which were changed five rimes during the trial. The identification of the code was known only to the hospital pharmacist. The method of anaesthesia was intravenous thiopentone 50 mg/stone (7.9 mg/kg), suxamethonium, oral intubation, nitrous oxide, oxygen and halothane 1 per cent. Each child was seen personally by the writer on the evening before operation, the method of induction of anaesthesia explained to him and a promise elicited to hold the hand quite still during venepuncrure. All the anaesthetics were given by the author. Palatability of premedication (table II). The solutions were flavoured with a sweet syrup and oil of peppermint. The latter was added primarily in an attempt to disguise the charac-80

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“…36 Gillet and Ke11i2 compared trimeprazine to a placebo but the trial was not randomised or blind and there was no statistical analysis.…”

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confidence: 99%

Pre‐induction behaviour of children A review of placebo‐controlled trials of sedatives

Morgan‐Hughes

Bangham

1990

Anaesthesia

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Trimeprazine Tartrate for Premedication of Children

Cited by 23 publications

References 4 publications

ORAL PREMEDICATION IN CHILDREN WITH TRIMEPRAZINE: The Effect of varying Dosage and Timing

ORAL PREMEDICATION IN CHILDREN WITH TRIMEPRAZINE: The Effect of varying Dosage and Timing

Oral Premedication in Children

Pre‐induction behaviour of children A review of placebo‐controlled trials of sedatives

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