Trimellitic anhydride-induced airway syndromes: Clinical and immunologic studies

Zeiss, C. Raymond; Patterson, Roy; Pruzansky, Jacob J.; Miller, Michael M.; Rosenberg, Michael; Levitz, Doris

doi:10.1016/0091-6749(77)90033-1

Cited by 238 publications

(75 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The present study is also consistent with our previous study showing increased numbers of RBC in the BAL fluid in sensitized but not in non-sensitized guinea pigs after TMA-GPSA challenge (Larsen et al, 2001). Hemoptysis in humans has been reported to occur in sensitized individuals after TMA exposure (Zeiss et al, 1977), and TMA-induced lung injury observed in sensitized animals is consistent with immunologically mediated hemoptysis in humans.…”

Section: Discussionmentioning

confidence: 56%

“…Clinical studies by Zeiss et al (1977) described non-sensitized workers having TMA-induced symptoms of wheeze and dyspnea. In addition, studies monitoring respiratory patterns in nonsensitized mice and rats have suggested TMA causes airway obstruction (Schaper and Brost, 1991;Arts et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

“…It is also an occupational allergen, with exposure typically occurring by inhalation of TMA dust. TMA causes respiratory sensitization and several well defined immunologically-mediated respiratory syndromes, most notably asthma (Grammer et al, 1997;Zeiss et al, 1977). The respiratory effects of TMA in non-sensitized individuals are not well characterized.…”

Section: Introductionmentioning

confidence: 99%

“…The respiratory effects of TMA in non-sensitized individuals are not well characterized. However, rhinorrhea, epistaxis, cough, dyspnea and occasional wheezing have been reported to occur upon the first large exposure to TMA in individuals with no evidence of sensitization (Zeiss et al, 1977). Additionally, Grammer et al (1998) reported a case of one worker at a TMA manufacturing facility that had TMA-induced asthma in the absence of significant IgE, the antibody implicated in the pathogenesis of TMA-induced asthma.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Trimellitic anhydride (TMA) dust induces airway obstruction and eosinophilia in non-sensitized guinea pigs

Larsen

Regal

2002

Toxicology

View full text Add to dashboard Cite

Trimellitic anhydride (TMA) causes asthma after a latency period of sensitization. In non-sensitized humans and animals, limited studies indicate that TMA exposure may also cause symptoms of asthma without a latency period. Our previous studies (J. Pharmacol. Exp. Ther. 296 (2001) 284) in a guinea pig model of TMA-induced asthma demonstrated that sensitization and the complement system were required for eosinophilia. TMA conjugated to guinea pig serum albumin (TMA-GPSA) was used to elicit the response. Since occupational exposure to TMA occurs by inhalation of dust, the present studies determined if exposure to TMA dust in a non-sensitized guinea pig elicited airway obstruction and inflammation, and whether a significantly greater response occurred after a latency period of sensitization. Guinea pigs were intradermally injected with either corn oil (non-sensitized animals) or 30% TMA (sensitized animals). Three weeks later they were challenged by intratracheal insufflation with 1 mg TMA dust or lactose dust (control) using a dry powder delivery device. Pulmonary resistance, dynamic lung compliance, mean arterial blood pressure and heart rate were monitored for 10 min. In non-sensitized guinea pigs, significant increases in pulmonary resistance and decreases in dynamic lung compliance and blood pressure occurred after TMA challenge. In sensitized animals, the same dose of TMA caused significantly greater effects compared to nonsensitized animals. In a separate experiment, cellular infiltration into the lung was determined 24 h after challenge with TMA dust or lactose dust. In both non-sensitized and sensitized animals, eosinophils in the lung tissue were increased after TMA dust challenge compared to controls. Thus, these studies suggest that the response in non-sensitized animals differs depending on whether TMA dust or TMA-GPSA is used to elicit the response. TMA dust elicits significant airway obstruction and eosinophilia in a non-sensitized animal, with even greater airway obstruction occurring in a sensitized animal.

show abstract

Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Trimellitic anhydride (TMA) dust induces airway obstruction and eosinophilia in non-sensitized guinea pigs

Larsen

Regal

2002

Toxicology

View full text Add to dashboard Cite

show abstract

“…For most chemicals associated with occupational allergy it is not indicated, with the exception of agents known to be implicated in IgE reactions, such as platinum salts, acid anhydrides, polyisocyanates, sulphonechloramide and succinylcholine analogues. [35][36][37] …”

Section: Skin Prick Tests General Considerations and Indicationsmentioning

confidence: 99%

Skin prick tests and allergy diagnosis

Antunes

Borrego

Romeira

et al. 2009

Allergologia et Immunopathologia

View full text Add to dashboard Cite

Skin testing remains an essential diagnostic tool in modern allergy practice. A signifi cant variability has been reported regarding technical procedures, interpretation of results and documentation. This review has the aim of consolidating methodological recommendations through a critical analysis on past and recent data. This will allow a better understanding on skin prick test (SPT) history; technique; (contra-) indications; interpretation of results; diagnostic pitfalls; adverse reactions; and variability factors. Skin has an important physiological role in the internal balance homeostasis and constitutes a crucial barrier against external aggressions, with well-known immunological properties. 1 It has been used by allergists for decades as an easily assessed laboratory of the immunological status of the individual.The fi rst skin testing technique was developed by Charles H. Blackley in 1865, a Manchester homeopathic physician with allergic rhinitis. He abraded a quarter-inch area of his skin with a lancet and then applied grass pollen grains. 2 The so-called scratch test was later adopted by Schloss for the diagnosis of food allergy in children. 3 Epicutaneous tests can be divided into scratch tests and prick/puncture tests. The fi rst method, proposed by Blackley 2 , implied a linear scratch without drawing blood and could either be performed fi rst, with the extract then dropped on the abraded skin, or be made through a drop of extract. 4 Although it was used extensively in the past, this technique became progressively obsolete due to patient discomfort, poor reproducibility, possible residual lesions and newer and innocuous procedures. 4 Therefore, scratch test is mentioned here for historical purposes only. It was Sir Thomas Lewis who, in 1924, fi rst applied skin prick tests (SPT). 5 Nevertheless, their generalised use in clinical practice only became a reality about 30 years ago, as a result of technique modifi cations proposed by Pepys. 6 For the purpose of this review and for easier comprehension, skin testing will be referred interchangeably as SPT, whatever device is used for its application.In 1966, Ishizaka's work on immunoglobulin E (IgE) and immediate hypersensitivity reactions 7 established the scientifi c corpus to what was done till then on a strictly empiric basis.As written by Dr Walzer in 1974, "the fact that skin testing has not turned out to be a simple and completely reliable technique does not detract from the fact that, when it is intelligently and skilfully performed, it remains the most effective diagnostic procedure in reaginic allergic disorders". 8 The reliability of skin testing and proper documentation of test results are essential in allergy practice. A recent survey to all physician members and fellows of the American College of Allergy, Asthma and Immunology practicing in the

show abstract

Trimellitic anhydride Toxicity. A cause of acute multisystem failure

Rivera¹,

Nicotra²,

Byron³

et al. 1981

Archives of Internal Medicine

View full text Add to dashboard Cite

A person exposed to trimellitic anhydride (TMA) an epoxy resin widely used in industry, experienced respiratory failure, anemia, and gastrointestinal bleeding. A lung biopsy specimen demonstrated intra-alveolar hemorrhage and damage to alveolar lining cells. The patient and six co-workers were examined. Results indicated the presence of hemolytic antibodies directed against TMA-haptenized erythrocytes, IgG, IgA, and IgM antibodies directed against TMA-erythrocyte complexes, and antibodies against TMA-human serum albumin. Antibody levels in the patient were greater than in the co-workers. The elevated antibody levels demonstrate the antigenic potential of TMA. However, the cause of the pulmonary and hematologic damage remains uncertain and may represent either immunologic or direct toxic effects of TMA. In patients with multisystem failure of this nature, occupational hazards should be added to the differential diagnosis.

show abstract

Trimellitic anhydride-induced airway syndromes: Clinical and immunologic studies

Cited by 238 publications

References 13 publications

Trimellitic anhydride (TMA) dust induces airway obstruction and eosinophilia in non-sensitized guinea pigs

Trimellitic anhydride (TMA) dust induces airway obstruction and eosinophilia in non-sensitized guinea pigs

Skin prick tests and allergy diagnosis

Trimellitic anhydride Toxicity. A cause of acute multisystem failure

Contact Info

Product

Resources

About