TRIM52 is a primate-specific player in the DNA repair process under tight proteolytic control by a triad of giant E3 ligases
Alexandra Shulkina,
Kathrin Hacker,
Julian F. Ehrmann
et al.
Abstract:Tripartite motif 52 (TRIM52) exhibits strong positive selection in humans, yet is lost in many other mammals. In contrast to what one would expect for such a non-conserved factor, TRIM52 loss compromises cell fitness. We set out to determine the cellular function of TRIM52. Genetic and proteomic analyses revealed TRIM52's involvement in resolving topoisomerase 2 (TOP2)-DNA cross-links, mitigating DNA damage and preventing cell-cycle arrest. Consistent with a fitness-promoting function, TRIM52 is upregulated in… Show more
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